Protein detail
CTNB1
Catenin beta-1 (Beta-catenin)
Entry name CTNB1 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Catenin beta-1 (Beta-catenin)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of the urinary system
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Ensembl
Entrez Gene Symbol
Gene Synonym
armadillobeta-cateninCTNNB
Gene Description
Catenin beta 1
Chromosome
3
Position
41194741-41260096
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Cancer-related genes:Candidate cancer biomarkers
- Human disease related genes:Cancers:Cancers of the urinary system
- Disease related genes
- Human disease related genes:Nervous system diseases:Eye disease
Cellular Component
- GO:0000791 euchromatin
- GO:0000922 spindle pole
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005667 transcription regulator complex
- GO:0005737 cytoplasm
- GO:0005813 centrosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
- GO:0005912 adherens junction
- GO:0005916 fascia adherens
- GO:0005923 bicellular tight junction
- GO:0005925 focal adhesion
- GO:0005938 cell cortex
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016327 apicolateral plasma membrane
- GO:0016328 lateral plasma membrane
- GO:0016342 catenin complex
- GO:0016600 flotillin complex
- GO:0030018 Z disc
- GO:0030027 lamellipodium
- GO:0030054 cell junction
- GO:0030877 beta-catenin destruction complex
- GO:0031528 microvillus membrane
- GO:0032991 protein-containing complex
- GO:0032993 protein-DNA complex
- GO:0034750 Scrib-APC-beta-catenin complex
- GO:0042734 presynaptic membrane
- GO:0045177 apical part of cell
- GO:0045202 synapse
- GO:0045211 postsynaptic membrane
- GO:0048471 perinuclear region of cytoplasm
- GO:0070062 extracellular exosome
- GO:0070369 beta-catenin-TCF7L2 complex
- GO:0071944 cell periphery
- GO:0098685 Schaffer collateral - CA1 synapse
- GO:0098831 presynaptic active zone cytoplasmic component
- GO:0098978 glutamatergic synapse
- GO:0099092 postsynaptic density, intracellular component
- GO:1990711 beta-catenin-ICAT complex
- GO:1990907 beta-catenin-TCF complex
- GO:1990909 Wnt signalosome
Molecular Function
- GO:0001221 transcription coregulator binding
- GO:0001222 transcription corepressor binding
- GO:0003682 chromatin binding
- GO:0003713 transcription coactivator activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0016922 nuclear receptor binding
- GO:0019899 enzyme binding
- GO:0019900 kinase binding
- GO:0019901 protein kinase binding
- GO:0019903 protein phosphatase binding
- GO:0030331 nuclear estrogen receptor binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0044325 transmembrane transporter binding
- GO:0045294 alpha-catenin binding
- GO:0045296 cadherin binding
- GO:0046332 SMAD binding
- GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
- GO:0070411 I-SMAD binding
- GO:0097718 disordered domain specific binding
- GO:0140297 DNA-binding transcription factor binding
Biological Process
KEGG
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04670 Leukocyte transendothelial migration
- KEGG:hsa04916 Melanogenesis
- KEGG:hsa04919 Thyroid hormone signaling pathway
- KEGG:hsa04934 Cushing syndrome
- KEGG:hsa04936 Alcoholic liver disease
- KEGG:hsa05010 Alzheimer disease
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05100 Bacterial invasion of epithelial cells
- KEGG:hsa05132 Salmonella infection
- KEGG:hsa05160 Hepatitis C
- KEGG:hsa05163 Human cytomegalovirus infection
- KEGG:hsa05165 Human papillomavirus infection
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05205 Proteoglycans in cancer
- KEGG:hsa05210 Colorectal cancer
- KEGG:hsa05213 Endometrial cancer
- KEGG:hsa05215 Prostate cancer
- KEGG:hsa05216 Thyroid cancer
- KEGG:hsa05217 Basal cell carcinoma
- KEGG:hsa05224 Breast cancer
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
- KEGG:hsa05412 Arrhythmogenic right ventricular cardiomyopathy
- KEGG:hsa05418 Fluid shear stress and atherosclerosis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-109581 apoptosis
- R-hsa-111465 apoptotic cleavage of cellular proteins
- R-hsa-351906 apoptotic cleavage of cell adhesion proteins
- R-hsa-75153 apoptotic execution phase
- R-hsa-9824439 bacterial infection pathways
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-196299 beta catenin phosphorylation cascade
- R-hsa-4411364 binding of tcf lef ctnnb1 to target gene promoters
- R-hsa-4086398 ca2 pathway
- R-hsa-9733709 cardiogenesis
- R-hsa-9833576 cdh11 homotypic and heterotypic interactions
- R-hsa-9855142 cellular responses to mechanical stimuli
- R-hsa-8953897 cellular responses to stimuli
- R-hsa-1500931 cell cell communication
- R-hsa-446728 cell junction organization
- R-hsa-389948 co inhibition by pd 1
- R-hsa-1834949 cytosolic sensors of pathogen associated dna
- R-hsa-3769402 deactivation of the beta catenin transactivating complex
- R-hsa-195253 degradation of beta catenin by the destruction complex
- R-hsa-9918481 dengue virus host interactions
- R-hsa-9839923 dengue virus infection
- R-hsa-4641262 disassembly of the destruction complex and recruitment of axin to the membrane
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-9796292 formation of axial mesoderm
- R-hsa-9823730 formation of definitive endoderm
- R-hsa-9793380 formation of paraxial mesoderm
- R-hsa-201722 formation of the beta catenin tcf transactivating complex
- R-hsa-9830364 formation of the nephric duct
- R-hsa-9758941 gastrulation
- R-hsa-9754189 germ layer formation at gastrulation
- R-hsa-9856530 high laminar flow shear stress activates signaling by piezo1 and pecam1 cdh5 kdr in endothelial cells
- R-hsa-400508 incretin synthesis secretion and inactivation
- R-hsa-5663205 infectious disease
- R-hsa-8876493 inla mediated entry of listeria monocytogenes into host cells
- R-hsa-168249 innate immune system
- R-hsa-9830369 kidney development
- R-hsa-8876384 listeria monocytogenes entry into host cells
- R-hsa-3134973 lrr flii interacting protein 1 lrrfip1 activates type i ifn production
- R-hsa-9856651 mitf m dependent gene expression
- R-hsa-9730414 mitf m regulated melanocyte development
- R-hsa-525793 myogenesis
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-5357801 programmed cell death
- R-hsa-9762292 regulation of cdh11 function
- R-hsa-9764302 regulation of cdh19 expression and function
- R-hsa-9764561 regulation of cdh1 function
- R-hsa-9768727 regulation of cdh1 posttranslational processing and trafficking to plasma membrane
- R-hsa-9764260 regulation of expression and function of type ii classical cadherins
- R-hsa-9759476 regulation of homotypic cell cell adhesion
- R-hsa-9825892 regulation of mitf m dependent genes involved in cell cycle and proliferation
- R-hsa-9824585 regulation of mitf m dependent genes involved in pigmentation
- R-hsa-9909648 regulation of pd l1 cd274 expression
- R-hsa-9909649 regulation of pd l1 cd274 transcription
- R-hsa-388841 regulation of t cell activation by cd28 family
- R-hsa-5626467 rho gtpases activate iqgaps
- R-hsa-195258 rho gtpase effectors
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-8951430 runx3 regulates wnt signaling
- R-hsa-4839743 signaling by ctnnb1 phospho site mutants
- R-hsa-9006934 signaling by receptor tyrosine kinases
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-194138 signaling by vegf
- R-hsa-195721 signaling by wnt
- R-hsa-4791275 signaling by wnt in cancer
- R-hsa-9824272 somitogenesis
- R-hsa-9834899 specification of the neural plate border
- R-hsa-381771 synthesis secretion and inactivation of glucagon like peptide 1 glp 1
- R-hsa-201681 tcf dependent signaling in response to wnt
- R-hsa-9856649 transcriptional and post translational regulation of mitf m expression and activity
- R-hsa-8878159 transcriptional regulation by runx3
- R-hsa-8853884 transcriptional regulation by ventx
- R-hsa-5218920 vegfr2 mediated vascular permeability
- R-hsa-9824446 viral infection pathways
Canonical Pathways
- M83 Pid cdc42 reg pathway
- M62 Pid ephb fwd pathway
- M214 Pid erbb1 internalization pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
218 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CTNNB1 | CDH1 | P12830 | S | 45 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:21152425 |
| CTNNB1 | GDNF | P39905 | Y | 654 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:25423132 |
| CTNNB1 | PDGFB | P01127 | Y | 654 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:22247700 |
| CTNNB1 | EGF | P01133 | Y | 333 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22056988ProtMapper:23178880ProtMapper:23070542 |
| CTNNB1 | EGF | P01133 | Y | 142 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:25130271 |
| CTNNB1 | EGF | P01133 | S | 675 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:29764501ProtMapper:21303971 |
| CTNNB1 | HIF1A | Q16665 | Y | 333 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:23178880 |
| CTNNB1 | PKM | P14618 | Y | 333 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:27485204 |
| CTNNB1 | RAC1 | P63000 | S | 605 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:30650643ProtMapper:19417647ProtMapper:28626389 |
| CTNNB1 | RAC1 | P63000 | S | 191 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:30650643ProtMapper:19417647ProtMapper:28626389ProtMapper:26403202 |
Ligand-Receptor Signaling
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
136 records.
Protein Complex Composition
41 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| DLG5-SORBS3-CTNNB1 complex | CTNNB1DLG5SORBS3 | O60504P35222Q8TDM6 | 0:0:0 | CORUM | CORUM:6264 | 12657639 |
| ICAT-AR-beta-catenin complex | ARCTNNB1CTNNBIP1 | P10275P35222Q9NSA3 | 0:0:0 | CORUM | CORUM:6206 | 21885566 |
| JUN-TCF4-CTNNB1 complex | CTNNB1JUNTCF4 | P05412P15884P35222 | 1:1:1 | CompleatCORUM | CORUM:1816Compleat:HC1181 | 16007074 |
| OVOL2-beta-catenin-TCF4 complex | CTNNB1OVOL2TCF4 | P15884P35222Q9BRP0 | 0:0:0 | CORUM | CORUM:6364 | 26619963 |
| RHAMM-beta-catenin complex | CTNNB1HMMR | O75330P35222 | 0:0 | CORUM | CORUM:6359 | 26825774 |
| SETD7-YAP-AXIN1-beta-catenin complex | AXIN1CTNNB1SETD7YAP1 | O15169P35222P46937Q8WTS6 | 0:0:0:0 | CORUM | CORUM:6343 | 27046831 |
| Sox4-beta-catenin-p300 complex | CTNNB1EP300SOX4 | P35222Q06945Q09472 | 0:0:0 | CORUM | CORUM:6354 | 26841870 |
| TCF4-CTNNB1 complex | CTNNB1TCF4 | P15884P35222 | 1:1 | CompleatCORUM | CORUM:5262Compleat:HC3439 | 15782138 |
| TCF4-CTNNB1-CREBBP complex | CREBBPCTNNB1TCF4 | P15884P35222Q92793 | 1:1:1 | CompleatCORUM | CORUM:5264Compleat:HC1802 | 15782138 |
| TCF4-CTNNB1-EP300 complex | CTNNB1EP300TCF4 | P15884P35222Q09472 | 1:1:1 | CompleatCORUM | CORUM:5261Compleat:HC818 | 15782138 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Mass spectrometry [LTQ-FT Ultra] | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
781
Mass
85,497
Sequence
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
3D Structural Models
Turn
20..22; 27..29; 39..41; 368..371; 428..430; 634..636; 663..665
Helix
145..160; 165..179; 182..189; 192..204; 208..221; 225..233; 236..243; 249..265; 269..275; 278..284; 285..287; 291..303; 309..317; 320..330; 334..347; 353..359; 362..367; 375..389; 392..394; 399..408; 414..427; 432..440; 443..454; 458..471; 478..487; 491..496; 504..517; 521..523; 524..529; 532..547; 566..580; 584..592; 596..601; 602..604; 608..621; 625..633; 637..642; 643..645; 649..662; 668..682; 688..690
Beta Strand
23..26; 161..164; 473..475; 499..501; 550..552; 554..557; 561..563; 778..780
3D Structure
NMR spectroscopy (1); X-ray crystallography (46)
Domain & Motif Annotations
Compositional Bias
734..745; Basic and acidic residues
Repeat
151..191; ARM 1; 193..234; ARM 2; 235..276; ARM 3; 277..318; ARM 4; 319..360; ARM 5; 361..389; ARM 6; 400..441; ARM 7; 442..484; ARM 8; 489..530; ARM 9; 531..571; ARM 10; 594..636; ARM 11; 637..666; ARM 12
Region
2..23; Interaction with VCL; 34..57; Disordered; 156..178; Interaction with BCL9; 705..781; Disordered; 772..781; Interaction with SCRIB
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantIntellectual disability
Related Diseases
Biomarker
Phase 1/2; Phase 1; Approved
Drugs
PRI-724CHEMBL:CHEMBL2172378CELECOXIBCHEMBL:CHEMBL533293NULLLENALIDOMIDECYCLOPHOSPHAMIDE ANHYDROUSSKF-86002SAM68 MODULATOR CWP232291MW150SB203580PF-03715455TALMAPIMODCETUXIMABEVEROLIMUSOSUGACESTATPEXMETINIBTRICIRIBINEMAPK13-IN-1NIROGACESTATDITHIAZANINE IODIDECEQ508ACUMAPIMODPF-670462AZD7624MPI-0479605TRAMETINIB DIMETHYL SULFOXIDEPAMAPIMODNEFLAMAPIMODCOMPOUND 4E [PMID: 35546685]PP1RALIMETINIBSORAFENIBTHALIDOMIDENDPPCLOSMAPIMODSB202190PH-797804IMATINIBDEXAMETHASONETAK-715EOSIN_YANTI-PD-L1 MONOCLONAL ANTIBODYOSIMERTINIBDORAMAPIMODDILMAPIMODVX-702CBS-3595AZD6703SB220025ANTI-CTLA-4 MONOCLONAL ANTIBODYBAY1217389VANTICTUMABLETROZOLEARRY-371797EMPESERTIBMPS1-IN-1BMS-582949CHEMBL:CHEMBL410484NMS-P715TEMSIROLIMUSCOMPOUND 12 [PMID: 22521646]7-HYDROXYSTAUROSPORINECABOZANTINIB S-MALATEFLUORESCEIN SODIUMRECOMBINANT HUMAN ENDOSTATINCHEMBL:CHEMBL91638
Interaction Protein
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
Interaction Count
47
Interaction Dataset
intact_biogridintact_biogrid_opencell_bioplexintact_biogrid_opencellbiogrid_bioplexbiogrid_opencellintact_biogrid_bioplex