Protein detail

CTNB1

Catenin beta-1 (Beta-catenin)

Entry name
CTNB1
UniProt ID
EVMP score
0.50
Frequency
3
Transmembrane count
Protein classification
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Catenin beta-1 (Beta-catenin)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of the urinary system
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Entrez Gene Symbol
Gene Synonym
armadillobeta-cateninCTNNB
Gene Description
Catenin beta 1
Chromosome
3
Position
41194741-41260096
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of the urinary system
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Reactome
Canonical Pathways
  • M83 Pid cdc42 reg pathway
  • M62 Pid ephb fwd pathway
  • M214 Pid erbb1 internalization pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

218 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CTNNB1CSNK2A1P68400T393phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSiteKEA:12700239SIGNOR:12700239ProtMapper:12700239
CTNNB1CSNK2A1P68400T102phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperSIGNOR:12432063HPRD:12432063KEA:12432063ProtMapper:12432063
CTNNB1CSNK2A1P68400T112phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperKEASIGNOR_ProtMapperSIGNOR:12432063HPRD:12432063KEA:12432063ProtMapper:12432063
CTNNB1CSNK2A1P68400S29phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperSIGNOR:12432063HPRD:12432063KEA:12432063ProtMapper:12432063
CTNNB1PRKACAP17612S552phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:16476742ProtMapper:16476742
CTNNB1PRKACAP17612S675phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:16476742ProtMapper:16476742
CTNNB1PRKACAP17612S45phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
CTNNB1PAK4O96013S675phosphorylationSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:28007610ProtMapper:23543898SIGNOR:22173096ProtMapper:30755582ProtMapper:29330094ProtMapper:26068882ProtMapper:22173096ProtMapper:25335797ProtMapper:25560280ProtMapper:29399291
CTNNB1FERP16591Y142phosphorylationSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperProtMapper:12640114ProtMapper:24511551ProtMapper:19047464ProtMapper:22264731ProtMapper:19166962ProtMapper:14517306SIGNOR:12640114KEA:12640114ProtMapper:25803041
CTNNB1AKT2P31751S552phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:17287208ProtMapper:17287208
Page 5 of 22PreviousNext

Ligand-Receptor Signaling

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
icamcell_adhesionZhong2015YesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
tight_junctiontight_junctionGO_IntercellYesYesNoNoNo
tight_junctiontight_junctionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
Page 1 of 2Next

Regulatory Interaction Network

136 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
CAD12P55289CTNB1P35222YesYesNoSIGNORSIGNOR:21255999
CADH8P55286CTNB1P35222YesYesNoHPRDHINTSIGNORBioGRIDSIGNOR:21255999HINT:9521872BioGRID:9521872HPRD:9521872HINT:33961781
I2BPLQ9H1B7CTNB1P35222YesNoYesSIGNORSIGNOR:29374064
CADH5P33151CTNB1P35222YesYesNoWangSIGNORHPRDHINTBioGRIDIntActSPIKE_LCHINT:17057644HPRD:12413882IntAct:39232006SIGNOR:21255999IntAct:18287330SPIKE_LC:17057644HINT:18662404HINT:18287330HPRD:17057644IntAct:17057644BioGRID:23243000HINT:20123964HINT:33961781IntAct:20123964
IKKAO15111CTNB1P35222YesNoNophosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointProtMapperHPRDHINTBioGRIDACSNInnateDBPhosphoSitePhosphoSite_ProtMapperHINT:11527961ACSN:11967263InnateDB:11527961PhosphoSite:16199882PhosphoSite:33832512PhosphoSite:32041324PhosphoSite:34117362PhosphoSite:19244247PhosphoSite:22511927PhosphoSite:19565571BioGRID:12589056PhosphoSite:34290402PhosphoSite:33651074ACSN:8666229HINT:12589056HPRD:11527961PhosphoSite:23727580PhosphoSite:17996206ACSN:7542250PhosphoSite:11751573PhosphoSite:17018282PhosphoSite:15829978PhosphoSite:25639486PhosphoSite:28615517ACSN:12051714PhosphoSite:20419129PhosphoSite:32046730PhosphoSite:9312064PhosphoSite:25660024PhosphoSite:20300119PhosphoSite:27484798ACSN:12799363PhosphoSite:12000790PhosphoSite:20501806ACSN:11955436PhosphoSite:12799363PhosphoSite:25546293PhosphoSite:14500351PhosphoSite:11834740PhosphoSite:32075752PhosphoSite:11955436
MK08P45983CTNB1P35222YesNoNophosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperInnateDBREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:18573912PhosphoSite:17306568PhosphoSite:19061640PhosphoSite:30413483PhosphoSite:9065402ProtMapper:22369945PhosphoSite:12077367InnateDB:19667122PhosphoSite:25297629PhosphoSite:17260019PhosphoSite:21383695PhosphoSite:27835580PhosphoSite:12027456
Page 14 of 14Previous

Protein Complex Composition

41 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
TCF4-CTNNB1-SUMO1-EP300-HADAC6 complexCTNNB1EP300HDAC6SUMO1TCF4P15884P35222P63165Q09472Q9UBN71:1:1:1:1CompleatCORUMCORUM:5260Compleat:HC93415782138
TFC4-CTNNB1 complexCTNNB1TCF7L2P35222Q9NQB03:3CompleatCORUMPDBPDB:1jpwCompleat:HC3250CORUM:3155PDB:1jdh17072303
beta-catenin-B-cell lymphoma 9 protein complexBCL9CTNNB1O00512P352224:4CORUMPDBPDB:3sl9PDB:8y0pCORUM:633925312469
beta1-catenin - LEF1 complexCTNNB1LEF1P35222Q9UJU21:1ComplexPortal221117111711338811751639210751181475529211212302
CTNNB1NR5A2O00482P352221:1PDBPDB:3tx7
AXIN1BCL9CARM1CSNK1A1CTNNB1EP300GSK3BTCF7L2O00512O15169P35222P48729P49841Q09472Q86X55Q9NQB01:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC5777
BCL9CTNNB1E4F1EP300TCF7L2ZBTB16O00512P35222Q05516Q09472Q66K89Q9NQB01:1:1:1:1:1NetworkBlastCompleatCompleat:HC8356
AGPAT3BCL9CTNNB1EP300TCF7L2O00512P35222Q09472Q9NQB0Q9NRZ71:1:1:1:1NetworkBlastCompleatCompleat:HC5830
BCL9CTNNB1TCF7L2O00512P35222Q9NQB02:2:2PDBPDB:2gl7
AXIN1CTNNB1O15169P352221:2PDBPDB:8ru3PDB:8ru4
Page 3 of 5PreviousNext

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Polymer PrecipitationMass spectrometry [LTQ-FT Ultra]138731868
Sequence, Structure & Domains

Sequences

Length
781
Mass
85,497
Sequence
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL

3D Structural Models

Turn
20..22; 27..29; 39..41; 368..371; 428..430; 634..636; 663..665
Helix
145..160; 165..179; 182..189; 192..204; 208..221; 225..233; 236..243; 249..265; 269..275; 278..284; 285..287; 291..303; 309..317; 320..330; 334..347; 353..359; 362..367; 375..389; 392..394; 399..408; 414..427; 432..440; 443..454; 458..471; 478..487; 491..496; 504..517; 521..523; 524..529; 532..547; 566..580; 584..592; 596..601; 602..604; 608..621; 625..633; 637..642; 643..645; 649..662; 668..682; 688..690
Beta Strand
23..26; 161..164; 473..475; 499..501; 550..552; 554..557; 561..563; 778..780
3D Structure
NMR spectroscopy (1); X-ray crystallography (46)

Domain & Motif Annotations

Compositional Bias
734..745; Basic and acidic residues
Repeat
151..191; ARM 1; 193..234; ARM 2; 235..276; ARM 3; 277..318; ARM 4; 319..360; ARM 5; 361..389; ARM 6; 400..441; ARM 7; 442..484; ARM 8; 489..530; ARM 9; 531..571; ARM 10; 594..636; ARM 11; 637..666; ARM 12
Region
2..23; Interaction with VCL; 34..57; Disordered; 156..178; Interaction with BCL9; 705..781; Disordered; 772..781; Interaction with SCRIB
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantIntellectual disability
Biomarker
Phase 1/2; Phase 1; Approved
Interaction Protein
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
Interaction Count
47
Interaction Dataset
intact_biogridintact_biogrid_opencell_bioplexintact_biogrid_opencellbiogrid_bioplexbiogrid_opencellintact_biogrid_bioplex