Protein detail

CTNB1

Catenin beta-1 (Beta-catenin)

Entry name
CTNB1
UniProt ID
EVMP score
0.50
Frequency
3
Transmembrane count
Protein classification
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Catenin beta-1 (Beta-catenin)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of the urinary system
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Entrez Gene Symbol
Gene Synonym
armadillobeta-cateninCTNNB
Gene Description
Catenin beta 1
Chromosome
3
Position
41194741-41260096
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of the urinary system
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Reactome
Canonical Pathways
  • M83 Pid cdc42 reg pathway
  • M62 Pid ephb fwd pathway
  • M214 Pid erbb1 internalization pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

218 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CTNNB1PUF60Q9UHX1K666polyubiquitinationSIGNORSIGNOR:20181957
CTNNB1CSNK1DP48730S45phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:12114015ProtMapper:10023673SIGNOR:12000790KEA:11955436ProtMapper:10488109ProtMapper:12000790ProtMapper:9312064ProtMapper:9482734KEA:11818547ProtMapper:14966280KEA:12000790
CTNNB1CSNK1EP49674S45phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperKEA:12114015ProtMapper:10023673SIGNOR:12000790ProtMapper:12417018SIGNOR:12176352KEA:11955436ProtMapper:10488109ProtMapper:12000790ProtMapper:9312064ProtMapper:9482734KEA:11818547KEA:17570479ProtMapper:14966280KEA:12000790ProtMapper:12176352
CTNNB1CSNK2BP67870T112phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperSIGNOR:12432063HPRD:12432063KEA:12432063ProtMapper:12432063
CTNNB1CSNK2BP67870T102phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperSIGNOR:12432063HPRD:12432063KEA:12432063ProtMapper:12432063
CTNNB1CSNK2BP67870S29phosphorylationPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperSIGNOR:12432063HPRD:12432063KEA:12432063ProtMapper:12432063
CTNNB1PRKCDQ05655S715phosphorylationSparser_ProtMapperSIGNORProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:25639486ProtMapper:25639486
CTNNB1SIAH1Q8IUQ4K666polyubiquitinationSIGNORSIGNOR:20181957
CTNNB1TBL1XO60907K666polyubiquitinationSIGNORSIGNOR:20181957
CTNNB1TBL1XO60907K671polyubiquitinationSIGNORSIGNOR:20181957
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Ligand-Receptor Signaling

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
icamcell_adhesionZhong2015YesYesNoNoNo
cell_adhesioncell_adhesionOmniPathYesYesNoNoNo
tight_junctiontight_junctionGO_IntercellYesYesNoNoNo
tight_junctiontight_junctionOmniPathYesYesNoNoNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoNoNo
Page 1 of 2Next

Regulatory Interaction Network

136 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
PTK6Q13882CTNB1P35222YesNoYesSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefSIGNORiPTMnetProtMapperRLIMS-P_ProtMapperdbPTMREACH_ProtMapperPhosphoSite_ProtMapperdbPTM:20026641ProtMapper:20026641dbPTM:12640114ProtMapper:22264731SIGNOR:20026641ProtMapper:23398121
AURKAO14965CTNB1P35222YesYesNoHINTSIGNORSparser_ProtMapperProtMapperHINT:19652203HINT:26496610SIGNOR:25217103ProtMapper:25217103
KPCAP17252CTNB1P35222YesNoYesInnateDBREACH_ProtMapperSIGNORProtMapperProtMapper:32294900SIGNOR:25058461InnateDB:21952047ProtMapper:25058461ProtMapper:23071615
AMER1Q5JTC6CTNB1P35222YesYesYesWangHINTSIGNORIntActSIGNOR:21498506IntAct:17510365HINT:26496610HINT:17510365
SOX6P35712CTNB1P35222YesNoYesSIGNORSIGNOR:26893351
CTNB1P35222MYOD1P15172YesYesNoSIGNORSIGNOR:18316399
PP2AAP67775CTNB1P35222YesYesNoCancerCellMapWangSIGNORCancerCellMap:10644691SIGNOR:19061640
PTPRZP23471CTNB1P35222YesYesNoHPRDSIGNORSIGNOR:23100427HPRD:10706604
CAD22Q9UJ99CTNB1P35222YesYesNoSIGNORSIGNOR:21255999
AKT2P31751CTNB1P35222YesYesNoSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperACSNInnateDBSIGNOR_ProtMapperPhosphoSite_ProtMapperACSN:20214616ACSN:22094462ACSN:20028971ACSN:18218901ACSN:21506126ACSN:21303971SIGNOR:17287208InnateDB:17287208ACSN:20398329ACSN:17680028ProtMapper:33303690ACSN:12040186ProtMapper:17287208ACSN:11882383
Page 9 of 14PreviousNext

Protein Complex Composition

41 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CTNNB1DAZAP2LEF1TLE1P35222Q04724Q15038Q9UJU21:1:1:1CompleatCFinderCompleat:HC9376
Page 5 of 5Previous

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Polymer PrecipitationMass spectrometry [LTQ-FT Ultra]138731868
Sequence, Structure & Domains

Sequences

Length
781
Mass
85,497
Sequence
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL

3D Structural Models

Turn
20..22; 27..29; 39..41; 368..371; 428..430; 634..636; 663..665
Helix
145..160; 165..179; 182..189; 192..204; 208..221; 225..233; 236..243; 249..265; 269..275; 278..284; 285..287; 291..303; 309..317; 320..330; 334..347; 353..359; 362..367; 375..389; 392..394; 399..408; 414..427; 432..440; 443..454; 458..471; 478..487; 491..496; 504..517; 521..523; 524..529; 532..547; 566..580; 584..592; 596..601; 602..604; 608..621; 625..633; 637..642; 643..645; 649..662; 668..682; 688..690
Beta Strand
23..26; 161..164; 473..475; 499..501; 550..552; 554..557; 561..563; 778..780
3D Structure
NMR spectroscopy (1); X-ray crystallography (46)

Domain & Motif Annotations

Compositional Bias
734..745; Basic and acidic residues
Repeat
151..191; ARM 1; 193..234; ARM 2; 235..276; ARM 3; 277..318; ARM 4; 319..360; ARM 5; 361..389; ARM 6; 400..441; ARM 7; 442..484; ARM 8; 489..530; ARM 9; 531..571; ARM 10; 594..636; ARM 11; 637..666; ARM 12
Region
2..23; Interaction with VCL; 34..57; Disordered; 156..178; Interaction with BCL9; 705..781; Disordered; 772..781; Interaction with SCRIB
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantIntellectual disability
Biomarker
Phase 1/2; Phase 1; Approved
Interaction Protein
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
Interaction Count
47
Interaction Dataset
intact_biogridintact_biogrid_opencell_bioplexintact_biogrid_opencellbiogrid_bioplexbiogrid_opencellintact_biogrid_bioplex