Protein detail

CTNB1

Catenin beta-1 (Beta-catenin)

Protein symbol
CTNB1
UniProt ID
EVMP score
0.50
Frequency
3
Transmembrane count
Protein classification
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Basic Information
Protein Names
Catenin beta-1 (Beta-catenin)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of the urinary system
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Entrez Gene Symbol
Gene Synonym
armadillobeta-cateninCTNNB
Gene Description
Catenin beta 1
Chromosome
3
Position
41194741-41260096
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway
Protein Function
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cancers:Cancers of the digestive system
  • Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
  • Human disease related genes:Other diseases:Mental and behavioural disorders
  • Predicted intracellular proteins
  • Human disease related genes:Cancers:Cancers of the breast and female genital organs
  • Cancer-related genes:Mutated cancer genes
  • Human disease related genes:Cancers:Cancers of endocrine organs
  • Human disease related genes:Skin diseases:Skin and soft tissue diseases
  • Cancer-related genes:Candidate cancer biomarkers
  • Human disease related genes:Cancers:Cancers of the urinary system
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Eye disease
Reactome
Canonical Pathways
  • M83 Pid cdc42 reg pathway
  • M62 Pid ephb fwd pathway
  • M214 Pid erbb1 internalization pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

218 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CTNNB1FYNP06241Y142phosphorylationPhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperdbPTMKEAphosphoELMSIGNOR_ProtMapperProtMapper:26509276ProtMapper:12640114ProtMapper:24511551ProtMapper:22340496dbPTM:12640114ProtMapper:22264731phosphoELM:12640114SIGNOR:12640114KEA:12640114dbPTM:20026641ProtMapper:25803041
CTNNB1SRCP12931Y654phosphorylationSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:11836526ProtMapper:21195420ProtMapper:10593980ProtMapper:23824743ProtMapper:27203386KEA:10593980ProtMapper:27177845ProtMapper:22247700ProtMapper:26918136ProtMapper:24816560ProtMapper:16831887SIGNOR:11279024ProtMapper:11279024ProtMapper:22264731ProtMapper:26453937ProtMapper:22605996ProtMapper:25850673ProtMapper:20840866KEA:11279024ProtMapper:23640056phosphoELM:11279024ProtMapper:25423132ProtMapper:12571228ProtMapper:21903109ProtMapper:12408824
CTNNB1SRCP12931Y86phosphorylationSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperProtMapper:11836526SIGNOR:11279024phosphoELM:11279024ProtMapper:10593980ProtMapper:12571228KEA:10593980ProtMapper:25164010ProtMapper:14517306ProtMapper:20840866KEA:11279024ProtMapper:11279024
CTNNB1SRCP12931Y333phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:23476652SIGNOR:22056988ProtMapper:22056988ProtMapper:25041845ProtMapper:22515442ProtMapper:22200182
CTNNB1CDK5Q00535S191phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperRLIMS-P_ProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:26509276dbPTM:17009320
CTNNB1CDK5Q00535S246phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperRLIMS-P_ProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:26509276dbPTM:17009320
CTNNB1PTK6Q13882Y64phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperdbPTM:20026641ProtMapper:20026641
CTNNB1PTK6Q13882Y142phosphorylationSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperRLIMS-P_ProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapperdbPTM:20026641ProtMapper:20026641dbPTM:12640114ProtMapper:22264731ProtMapper:23398121
CTNNB1PTK6Q13882Y331phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperdbPTMREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperdbPTM:20026641ProtMapper:20026641
CTNNB1PTK6Q13882Y333phosphorylationSparser_ProtMapperPhosphoSite_MIMPMIMPProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper:20026641
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Ligand-Receptor Signaling

12 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membraneplasma_membraneCellinkerNoNoNoNoNo
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
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Regulatory Interaction Network

136 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
CTNB1P35222TF7L2Q9NQB0YesYesNoWangKEGG-MEDICUSNetPathSIGNORHPRDHINTBioGRIDIntActInnateDBSPIKE_LCLit-BM-17SPIKELit-BM-17:17283121Lit-BM-17:19443654InnateDB:10080941Lit-BM-17:16230076Lit-BM-17:16306047HINT:17072303Lit-BM-17:11713475SPIKE_LC:17145710Lit-BM-17:19202075Lit-BM-17:20126258SPIKE:17145710HINT:16724116SPIKE_LC:18391971HINT:15525529HINT:30833792Lit-BM-17:22155184HINT:18772112HINT:17283121IntAct:11713475SIGNOR:20492721Lit-BM-17:17050667NetPath:11955446Lit-BM-17:26350900NetPath:9488439HINT:16630820HINT:16442529IntAct:11713476IntAct:16569639IntAct:16724116Lit-BM-17:11713476SPIKE_LC:16442529Lit-BM-17:16724116HINT:16007074HPRD:11713476HINT:16569639InnateDB:12446687HINT:11713476IntAct:19202075Lit-BM-17:22014570Lit-BM-17:27902311HINT:17052462IntAct:18772112SPIKE:17143293HINT:22056988Lit-BM-17:16630820SPIKE:16442529IntAct:22056988HPRD:15684397Lit-BM-17:21670201BioGRID:11713475HINT:20126258BioGRID:17914096HINT:19202075SPIKE:18391971HINT:12861022SPIKE_LC:17143293IntAct:22014570HINT:19816403IntAct:16442529Lit-BM-17:19304756HINT:15684397Lit-BM-17:22304967Lit-BM-17:19816403HINT:11713475Lit-BM-17:16569639HPRD:16306047Lit-BM-17:18772112HINT:15294866HINT:22014570Lit-BM-17:16442529IntAct:20126258HINT:16306047BioGRID:17050667HINT:29540185HPRD:12861022
CTNB1P35222NR4A1P22736YesYesNoSignaLink3SignaLink3:23331499SignaLink3:21362399SignaLink3:21986938
CTNB1P35222NR4A2P43354YesYesNoSignaLink3SignaLink3:23331499SignaLink3:21362399
CTNB1P35222NR4A3Q92570YesYesNoSignaLink3SignaLink3:23331499SignaLink3:21362399
APCP25054CTNB1P35222YesYesYesWangNetPathSIGNORProtMapperREACH_ProtMapperHPRDCui2007HINTBioGRIDIntActInnateDBCancerCellMapSPIKE_LCLit-BM-17SPIKELit-BM-17:11251183SPIKE_LC:17318191HPRD:15327769HINT:12628243HINT:22682247IntAct:15327769Lit-BM-17:8259519HPRD:9482734Lit-BM-17:12628243SPIKE_LC:17145710IntAct:8638126BioGRID:11533658HINT:8638126ProtMapper:19631635SPIKE:17145710HINT:15525529SPIKE_LC:19061640HINT:8259519HINT:36950384HINT:17318191Lit-BM-17:19576224Lit-BM-17:15327769HPRD:7890674Lit-BM-17:22682247Lit-BM-17:10545404Lit-BM-17:23840886SPIKE:16798748IntAct:9707618SPIKE:19061640IntAct:25241761IntAct:22682247Lit-BM-17:11707392Lit-BM-17:15355978Lit-BM-17:26496610Lit-BM-17:17318191InnateDB:11533658Lit-BM-17:9286858Lit-BM-17:16212417NetPath:8628279Lit-BM-17:27902311HPRD:12628243Lit-BM-17:15327768HINT:35271311InnateDB:15525529SPIKE_LC:15327769HINT:11707392SPIKE_LC:16798748HINT:22056988Lit-BM-17:11972058HINT:16212417HPRD:12000790IntAct:22056988ProtMapper:26910375Lit-BM-17:11533658IntAct:17318191SIGNOR:22083140HINT:15327769HINT:26496610SPIKE:9065401HINT:33961781Lit-BM-17:21664290HINT:9707618HPRD:15327768Lit-BM-17:11712088Lit-BM-17:25241761SPIKE:17318191SPIKE:15327769CancerCellMap:9065403NetPath:8638126HPRD:11166179BioGRID:10545404HINT:15294866HINT:16510874Lit-BM-17:15525529HINT:15327768SPIKE_LC:9065401
COMPLEX:P63208_Q13616_Q9Y297CTNB1P35222YesNoYesSPIKESPIKE_LCSIGNORSIGNOR:10023660SPIKE:19061640SPIKE_LC:19061640
CNBP1Q9NSA3CTNB1P35222YesNoYesWangSIGNORHPRDCui2007HINTBioGRIDIntActSPIKE_LCLit-BM-17SPIKEHINT:10898789Lit-BM-17:10898789HPRD:10898789IntAct:18287330SPIKE_LC:17145710Lit-BM-17:12408825SPIKE:17145710SPIKE_LC:12408824Lit-BM-17:17072306Lit-BM-17:21885566Lit-BM-17:26912724SPIKE:10898789HPRD:12417602BioGRID:10898789HINT:12408824HINT:18287330Lit-BM-17:17353931HINT:17353931SPIKE_LC:12408825IntAct:15893313IntAct:20211142SPIKE:15893313SPIKE_LC:10898789Lit-BM-17:12408824SIGNOR:10898789HINT:12408825SPIKE_LC:17353931HINT:33961781HPRD:12408825HINT:15893313HINT:12417602HINT:21885566IntAct:12408824IntAct:17353931SPIKE:17353931SPIKE_LC:15893313SPIKE:12408825SPIKE:12408824HINT:29540185HINT:15327768SIGNOR:12408824Lit-BM-17:15893313
ABL1P00519CTNB1P35222YesYesYesSPIKEBEL-Large-Corpus_ProtMapperSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetProtMapperRLIMS-P_ProtMapperSPIKE_LCPhosphoSitePhosphoSite_ProtMapperPhosphoSite:17618275ProtMapper:16099633SPIKE_LC:17318191SPIKE:17618275SPIKE_LC:20841568SPIKE_LC:17618275ProtMapper:17618275SPIKE_LC:16099633SPIKE:16099633SPIKE:20841568ProtMapper:24465953ProtMapper:20840866
NEK2P51955CTNB1P35222YesYesYesSIGNORProtMapperHINTInnateDBSPIKE_LCREACH_ProtMapperSPIKEInnateDB:18086858ProtMapper:30968157SPIKE:18086858HINT:18086858HINT:24501426SPIKE_LC:18086858SIGNOR:30968157
PAK1Q13153CTNB1P35222YesYesNoSparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperSPIKEPhosphoSite_ProtMapperSPIKE_LCProtMapper:23543898ProtMapper:27713506SPIKE_LC:21822311SIGNOR:21822311ProtMapper:21822311ProtMapper:26700621ProtMapper:33914026ProtMapper:23162742ProtMapper:31557964SPIKE:21822311ProtMapper:25639486ProtMapper:28423670ProtMapper:22369945ProtMapper:27910850ProtMapper:26547035ProtMapper:28007610ProtMapper:33582796ProtMapper:33796531ProtMapper:25225063ProtMapper:33171657ProtMapper:25472536
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Protein Complex Composition

41 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complexAXIN1CTNNB1GSK3BPPP2R5AO15169P35222P49841Q151721:1:1:1CompleatCORUMCompleat:HC1544CORUM:299811818547
CTNNAL1-CTNNB1 complexCTNNAL1CTNNB1P35222Q9UBT71:1CompleatCORUMCORUM:4095Compleat:HC198514993280
CTNNB1-DDX5-HDGF complexCTNNB1DDX5HDGFP17844P35222P518580:0:0CORUMCORUM:731828751441
CTNNB1-DNMT1 complexCTNNB1DNMT1P26358P352220:0CORUMCORUM:633625753001
CTNNB1-ESR1 complexCTNNB1ESR1P03372P352220:0CORUMCORUM:731217852416
CTNNB1-FERMT2-TCF7L2 complexCTNNB1FERMT2TCF7L2P35222Q96AC1Q9NQB00:0:0CORUMCORUM:690722699938
CTNNB1-FERMT2-YBX1 complexCTNNB1FERMT2YBX1P35222P67809Q96AC10:0:0CORUMCORUM:690827713156
CTNNB1-GID8 complexCTNNB1GID8P35222Q9NWU20:0CORUMCORUM:696128829046
CTNNB1-GLIS2 complexCTNNB1GLIS2P35222Q9BZE00:0CORUMCORUM:668017289029
CTNNB1-TBX5-YAP1 complexCTNNB1TBX5YAP1P35222P46937Q995930:0:0CORUMCORUM:665523245941
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Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Polymer PrecipitationMass spectrometry [LTQ-FT Ultra]138731868
Sequence, Structure & Domains

Sequences

Length
781
Mass
85,497
Sequence
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL

3D Structural Models

Turn
20..22; 27..29; 39..41; 368..371; 428..430; 634..636; 663..665
Helix
145..160; 165..179; 182..189; 192..204; 208..221; 225..233; 236..243; 249..265; 269..275; 278..284; 285..287; 291..303; 309..317; 320..330; 334..347; 353..359; 362..367; 375..389; 392..394; 399..408; 414..427; 432..440; 443..454; 458..471; 478..487; 491..496; 504..517; 521..523; 524..529; 532..547; 566..580; 584..592; 596..601; 602..604; 608..621; 625..633; 637..642; 643..645; 649..662; 668..682; 688..690
Beta Strand
23..26; 161..164; 473..475; 499..501; 550..552; 554..557; 561..563; 778..780
3D Structure
NMR spectroscopy (1); X-ray crystallography (46)

Domain & Motif Annotations

Compositional Bias
734..745; Basic and acidic residues
Repeat
151..191; ARM 1; 193..234; ARM 2; 235..276; ARM 3; 277..318; ARM 4; 319..360; ARM 5; 361..389; ARM 6; 400..441; ARM 7; 442..484; ARM 8; 489..530; ARM 9; 531..571; ARM 10; 594..636; ARM 11; 637..666; ARM 12
Region
2..23; Interaction with VCL; 34..57; Disordered; 156..178; Interaction with BCL9; 705..781; Disordered; 772..781; Interaction with SCRIB
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantIntellectual disability
Biomarker
Phase 1/2; Phase 1; Approved
Interaction Protein
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
Interaction Count
47
Interaction Dataset
intact_biogridintact_biogrid_opencell_bioplexintact_biogrid_opencellbiogrid_bioplexbiogrid_opencellintact_biogrid_bioplex