Protein detail
CTNB1
Catenin beta-1 (Beta-catenin)
Entry name CTNB1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 3 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Catenin beta-1 (Beta-catenin)
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (13)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Cancer-related genes:Candidate cancer biomarkers
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Ensembl
Entrez Gene Symbol
Gene Synonym (3)
armadillobeta-cateninCTNNB
Gene Description
Catenin beta 1
Chromosome
3
Position
41194741-41260096
Supporting publications (n)
3
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecificbrainCell SpecificBrain excitatory neurons
Function & Pathway8
Protein Function (13)
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Predicted intracellular proteins
- Human disease related genes:Cancers:Cancers of the breast and female genital organs
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Cancers:Cancers of endocrine organs
- Human disease related genes:Skin diseases:Skin and soft tissue diseases
- Cancer-related genes:Candidate cancer biomarkers
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Cellular Component (44)
- GO:0000791 euchromatin
- GO:0000922 spindle pole
- GO:0005634 nucleus
- GO:0005654 nucleoplasm
- GO:0005667 transcription regulator complex
- GO:0005737 cytoplasm
- GO:0005813 centrosome
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005911 cell-cell junction
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Molecular Function (21)
- GO:0001221 transcription coregulator binding
- GO:0001222 transcription corepressor binding
- GO:0003682 chromatin binding
- GO:0003713 transcription coactivator activity
- GO:0005102 signaling receptor binding
- GO:0005515 protein binding
- GO:0016922 nuclear receptor binding
- GO:0019899 enzyme binding
- GO:0019900 kinase binding
- GO:0019901 protein kinase binding
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Biological Process (3)
KEGG (34)
- hsa04015 Rap1 signaling pathway
- KEGG:hsa04310 Wnt signaling pathway
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04510 Focal adhesion
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04518 Integrin signaling
- KEGG:hsa04519 Cadherin signaling
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04670 Leukocyte transendothelial migration
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Reactome (75)
- R-hsa-1280218 adaptive immune system
- R-hsa-418990 adherens junctions interactions
- R-hsa-109581 apoptosis
- R-hsa-111465 apoptotic cleavage of cellular proteins
- R-hsa-351906 apoptotic cleavage of cell adhesion proteins
- R-hsa-75153 apoptotic execution phase
- R-hsa-9824439 bacterial infection pathways
- R-hsa-3858494 beta catenin independent wnt signaling
- R-hsa-196299 beta catenin phosphorylation cascade
- R-hsa-4411364 binding of tcf lef ctnnb1 to target gene promoters
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Canonical Pathways (3)
- M83 Pid cdc42 reg pathway
- M62 Pid ephb fwd pathway
- M214 Pid erbb1 internalization pathway
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence408
Enzyme-Mediated Modification (218)
218 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CTNNB1 | CSNK1G2 | P78368 | S | 45 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:12114015KEA:12000790KEA:11955436KEA:11818547 |
| CTNNB1 | TTBK2 | Q6IQ55 | S | 45 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CTNNB1 | TTBK1 | Q5TCY1 | S | 45 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CTNNB1 | VRK1 | Q99986 | S | 45 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CTNNB1 | VRK2 | Q86Y07 | S | 45 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CTNNB1 | VRK3 | Q8IV63 | S | 45 | phosphorylation | MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP | |
| CTNNB1 | PKD1 | P98161 | T | 120 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:22511927ProtMapper:26764245 |
| CTNNB1 | PKD1 | P98161 | T | 112 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:22511927 |
| CTNNB1 | PTPN6 | P29350 | Y | 654 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:12571228ProtMapper:20840866 |
| CTNNB1 | PTPN6 | P29350 | Y | 86 | phosphorylation | NCI-PID_ProtMapperProtMapper | ProtMapper:12571228ProtMapper:20840866 |
Ligand-Receptor Signaling (12)
12 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| icam | cell_adhesion | Zhong2015 | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | No | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network (136)
136 records.
Protein Complex Composition (41)
41 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Axin-PP2A A-PP2A C-GSK3-beta-beta-catenin complex | AXIN1CTNNB1GSK3BPPP2R5A | O15169P35222P49841Q15172 | 1:1:1:1 | CompleatCORUM | Compleat:HC1544CORUM:2998 | 11818547 |
| CTNNAL1-CTNNB1 complex | CTNNAL1CTNNB1 | P35222Q9UBT7 | 1:1 | CompleatCORUM | CORUM:4095Compleat:HC1985 | 14993280 |
| CTNNB1-DDX5-HDGF complex | CTNNB1DDX5HDGF | P17844P35222P51858 | 0:0:0 | CORUM | CORUM:7318 | 28751441 |
| CTNNB1-DNMT1 complex | CTNNB1DNMT1 | P26358P35222 | 0:0 | CORUM | CORUM:6336 | 25753001 |
| CTNNB1-ESR1 complex | CTNNB1ESR1 | P03372P35222 | 0:0 | CORUM | CORUM:7312 | 17852416 |
| CTNNB1-FERMT2-TCF7L2 complex | CTNNB1FERMT2TCF7L2 | P35222Q96AC1Q9NQB0 | 0:0:0 | CORUM | CORUM:6907 | 22699938 |
| CTNNB1-FERMT2-YBX1 complex | CTNNB1FERMT2YBX1 | P35222P67809Q96AC1 | 0:0:0 | CORUM | CORUM:6908 | 27713156 |
| CTNNB1-GID8 complex | CTNNB1GID8 | P35222Q9NWU2 | 0:0 | CORUM | CORUM:6961 | 28829046 |
| CTNNB1-GLIS2 complex | CTNNB1GLIS2 | P35222Q9BZE0 | 0:0 | CORUM | CORUM:6680 | 17289029 |
| CTNNB1-TBX5-YAP1 complex | CTNNB1TBX5YAP1 | P35222P46937Q99593 | 0:0:0 | CORUM | CORUM:6655 | 23245941 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Mass spectrometry [LTQ-FT Ultra] | 1 | 38731868 |
Sequence, Structure & Domains12
Sequences
Length
781
Mass
85,497
Sequence
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTSQVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLFRMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFHSGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTDL
3D Structural Models
Turn
20..22; 27..29; 39..41; 368..371; 428..430; 634..636; 663..665
Helix
145..160; 165..179; 182..189; 192..204; 208..221; 225..233; 236..243; 249..265; 269..275; 278..284; 285..287; 291..303; 309..317; 320..330; 334..347; 353..359; 362..367; 375..389; 392..394; 399..408; 414..427; 432..440; 443..454; 458..471; 478..487; 491..496; 504..517; 521..523; 524..529; 532..547; 566..580; 584..592; 596..601; 602..604; 608..621; 625..633; 637..642; 643..645; 649..662; 668..682; 688..690
Beta Strand
23..26; 161..164; 473..475; 499..501; 550..552; 554..557; 561..563; 778..780
3D Structure
NMR spectroscopy (1); X-ray crystallography (46)
Domain & Motif Annotations
Compositional Bias
734..745; Basic and acidic residues
Repeat
151..191; ARM 1; 193..234; ARM 2; 235..276; ARM 3; 277..318; ARM 4; 319..360; ARM 5; 361..389; ARM 6; 400..441; ARM 7; 442..484; ARM 8; 489..530; ARM 9; 531..571; ARM 10; 594..636; ARM 11; 637..666; ARM 12
Region
2..23; Interaction with VCL; 34..57; Disordered; 156..178; Interaction with BCL9; 705..781; Disordered; 772..781; Interaction with SCRIB
Protein Families
Beta-catenin family
Sequence Similarities
Belongs to the beta-catenin family.
Clinical Relevance8
Disease Involvement (3)
Cancer-related genesDisease variantIntellectual disability
Related Diseases (4)
Biomarker
Phase 1/2; Phase 1; Approved
Drugs (67)
PRI-724CHEMBL:CHEMBL2172378CELECOXIBCHEMBL:CHEMBL533293NULLLENALIDOMIDECYCLOPHOSPHAMIDE ANHYDROUSSKF-86002SAM68 MODULATOR CWP232291MW150SB203580PF-03715455TALMAPIMODCETUXIMABEVEROLIMUSOSUGACESTATPEXMETINIBTRICIRIBINEMAPK13-IN-1NIROGACESTATDITHIAZANINE IODIDECEQ508ACUMAPIMODPF-670462AZD7624MPI-0479605TRAMETINIB DIMETHYL SULFOXIDEPAMAPIMODNEFLAMAPIMODCOMPOUND 4E [PMID: 35546685]PP1RALIMETINIBSORAFENIBTHALIDOMIDENDPPCLOSMAPIMODSB202190PH-797804IMATINIBDEXAMETHASONETAK-715EOSIN_YANTI-PD-L1 MONOCLONAL ANTIBODYOSIMERTINIBDORAMAPIMODDILMAPIMODVX-702CBS-3595AZD6703SB220025ANTI-CTLA-4 MONOCLONAL ANTIBODYBAY1217389VANTICTUMABLETROZOLEARRY-371797EMPESERTIBMPS1-IN-1BMS-582949CHEMBL:CHEMBL410484NMS-P715TEMSIROLIMUSCOMPOUND 12 [PMID: 22521646]7-HYDROXYSTAUROSPORINECABOZANTINIB S-MALATEFLUORESCEIN SODIUMRECOMBINANT HUMAN ENDOSTATINCHEMBL:CHEMBL91638
Interaction Protein (47)
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
Interaction Count
47
Interaction Dataset (6)
intact_biogridintact_biogrid_opencell_bioplexintact_biogrid_opencellbiogrid_bioplexbiogrid_opencellintact_biogrid_bioplex
Supporting Publications3
| PMID | Title | Abstract |
|---|---|---|
| 22329422 | Quantitative proteome profiling of normal human circulating microparticles. | No abstract available |
| 23161513 | Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. | Exosomes from mutant KRAS cells contain many tumor-promoting proteins, including KRAS, EGFR, SRC family kinases, and integrins. |
| 28396511 | Database-augmented Mass Spectrometry Analysis of Exosomes Identifies Claudin 3 as a Putative Prostate Cancer Biomarker. | No abstract available |