EV MemProt Atlas

Basic Information11

Protein Names

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)

Protein Class (5)

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (6)

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Ensembl

ENSG00000186575

Entrez Gene Symbol

NF2

Gene Synonym (5)

ACNBANFmerlinmerlin-1SCH

Gene Description

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

Chromosome

22

Position

29603556-29698598

Supporting publications (n)

1

EVMP confidence score

0.50

Fluorescence & Localization6

Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway7

Protein Function (6)

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component (19)

Page 1 of 2

Molecular Function (3)

Biological Process (3)

KEGG (4)

Reactome (5)

Mediation Categories (4)

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence269

Enzyme-Mediated Modification (26)

26 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NF2	PAK2	Q13177	S	518	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15378014 ProtMapper:28007610 KEA:17081983 ProtMapper:11782491 ProtMapper:20302846 KEA:11782491 KEA:11719502 phosphoELM:15378014 ProtMapper:15378014 KEA:14981079 SIGNOR:18071304 ProtMapper:18071304
NF2	PAK2	Q13177	S	435	phosphorylation	KEA	KEA:15378014 KEA:17081983 KEA:11782491 KEA:11719502 KEA:14981079
NF2	PAK2	Q13177	S	476	phosphorylation	KEA	KEA:15378014 KEA:17081983 KEA:11782491 KEA:11719502 KEA:14981079
NF2	PAK2	Q13177	S	477	phosphorylation	KEA	KEA:15378014 KEA:17081983 KEA:11782491 KEA:11719502 KEA:14981079
NF2	PAK1	Q13153	S	518	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:18669648 ProtMapper:27285107 ProtMapper:25893302 ProtMapper:18071304 SIGNOR:18071304 ProtMapper:19165420 ProtMapper:23162742 ProtMapper:28090172 KEA:17081983 ProtMapper:20302846 KEA:11782491 dbPTM:18669648 KEA:14981079 KEA:15378014 ProtMapper:22567403 dbPTM:17081983 HPRD:19651622 HPRD:20068231 HPRD:19691289 KEA:11719502 ProtMapper:27345717 ProtMapper:26555075 ProtMapper:22105362 HPRD:11719502 ProtMapper:19036346
NF2	PAK1	Q13153	S	476	phosphorylation	HPRDKEA	HPRD:11719502 KEA:15378014 HPRD:19651622 HPRD:20068231 KEA:17081983 HPRD:19691289 HPRD:18669648 KEA:11719502 KEA:11782491 KEA:14981079
NF2	PAK1	Q13153	S	477	phosphorylation	HPRDKEA	HPRD:11719502 KEA:15378014 HPRD:19651622 HPRD:20068231 KEA:17081983 HPRD:19691289 HPRD:18669648 KEA:11719502 KEA:11782491 KEA:14981079
NF2	PAK1	Q13153	S	435	phosphorylation	HPRDKEA	HPRD:11719502 KEA:15378014 HPRD:19651622 HPRD:20068231 KEA:17081983 HPRD:19691289 HPRD:18669648 KEA:11719502 KEA:11782491 KEA:14981079
NF2	PPP1CB	P62140	S	518	dephosphorylation	SIGNOR	SIGNOR:18071304
NF2	PPP1CB	P62140	S	518	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:18071304

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Ligand-Receptor Signaling (13)

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network (13)

13 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MERL	P35240	LATS2	Q9NRM7	Yes	Yes	No	HINTLit-BM-17SIGNOR	Lit-BM-17:26045165 HINT:26045165 Lit-BM-17:24012335 SIGNOR:24012335
PAK2	Q13177	MERL	P35240	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEAInnateDBKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapper	InnateDB:11719502 KEA:15378014 ProtMapper:28007610 KEA:17081983 ProtMapper:11782491 ProtMapper:20302846 KEA:11782491 KEA:11719502 phosphoELM:15378014 ProtMapper:15378014 KEA:14981079 SIGNOR:18071304 ProtMapper:18071304
AKT1	P31749	MERL	P35240	Yes	No	No	AdhesomePhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperHINTPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:21722762 PhosphoSite:26506913 PhosphoSite:11782491 PhosphoSite:14981079 PhosphoSite:18835652 PhosphoSite:32115406 HINT:21750658 PhosphoSite:18071304 PhosphoSite:15743831 PhosphoSite:11719502 PhosphoSite:11703924 PhosphoSite:17175165 PhosphoSite:22673903 Adhesome:17891137 PhosphoSite:24166499 PhosphoSite:19691289 PhosphoSite:27285107 PhosphoSite:14724586 PhosphoSite:25925953 PhosphoSite:20178741 PhosphoSite:21750658 PhosphoSite:33058421 PhosphoSite:22516197 PhosphoSite:16267393 PhosphoSite:19651622 PhosphoSite:16652148 PhosphoSite:21857030 PhosphoSite:17566081 PhosphoSite:26997273 PhosphoSite:15378014 PhosphoSite:20860994 PhosphoSite:28273460 ProtMapper:17891137 HINT:17891137 PhosphoSite:17891137

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Protein Complex Composition (216)

216 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
BRCA1 CIT JUN NCOA3 PIAS1 PIAS2 PIAS4 RNF212 SUMO1 SUMO2 SUMO3 UBE2I	O14578 O75925 O75928 P05412 P38398 P55854 P61956 P63165 P63279 Q495C1 Q8N2W9 Q9Y6Q9	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6561
ASH2L CXXC1 DPY30 FKBP9 H3C11 H3C15 H4C4 KMT2A KMT2B RBBP5 RNF20 SETD1A SETD1B WDR5 WDR82	O15047 O95302 P61964 P62805 P68431 Q03164 Q15291 Q5VTR2 Q6UXN9 Q71DI3 Q9C005 Q9P0U4 Q9UBL3 Q9UMN6 Q9UPS6	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4204
BLM BRCA1 MRE11 MSH4 MSH5 RAD51 RNF212 RPA1 SUMO2 SUMO3 UBE2I WRN	O15457 O43196 P27694 P38398 P49959 P54132 P55854 P61956 P63279 Q06609 Q14191 Q495C1	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6199
H2AC15 H2BC11 H3C11 H4C4 RNF20 RNF40	O75150 P06899 P0C0S8 P62805 P68431 Q5VTR2	1:2:2:2:2:1	PDB	PDB:8gujPDB:8gui
IL36A RNF20 RNF40 WAC	O75150 Q5VTR2 Q9BTA9 Q9UHA7	0:0:0:0	hu.MAP2
CLUH DCAF4L2 KCNC1 KCNC3 KCNC4 RNF215	O75153 P48547 Q03721 Q14003 Q8NA75 Q9Y6U7	0:0:0:0:0:0	hu.MAP2
GCN1 INF2 NDUFA5 PDCD6	O75340 Q16718 Q27J81 Q92616	0:0:0:0	Havugimana2012	Havugimana2012:C_174
BLM BRCA1 MRE11 PIAS1 PIAS2 PIAS4 RAD51 RNF212 SUMO1 SUMO2 SUMO3 UBE2I	O75925 O75928 P38398 P49959 P54132 P55854 P61956 P63165 P63279 Q06609 Q495C1 Q8N2W9	1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8369
DNAJB5 KCNC1 KCNC3 KCNC4 RNF215	O75953 P48547 Q03721 Q14003 Q9Y6U7	0:0:0:0:0	hu.MAP2
BCOR BCORL1 BMI1 CBX7 FBRS KDM2B MORC4 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 RING1 RNF2 RYBP YAF2	O95931 P35226 P35227 Q06587 Q3KNV8 Q5H9F3 Q6W2J9 Q86SE9 Q8IY57 Q8N488 Q8NHM5 Q8TE76 Q99496 Q9BSM1 Q9BYE7 Q9HAH7	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	40326690

Sequence, Structure & Domains10

Sequences

Length

595

Mass

69,690

Sequence

MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL

Alternative Products

Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=I; IsoId=P35240-1; Sequence=Displayed; Name=2; IsoId=P35240-2; Sequence=VSP_000492; Name=3; Synonyms=II; IsoId=P35240-3; Sequence=VSP_007050, VSP_007051; Name=4; Synonyms=delE2/3; IsoId=P35240-4; Sequence=VSP_007041, VSP_007050, VSP_007051; Name=5; Synonyms=delE3; IsoId=P35240-5; Sequence=VSP_007042, VSP_007050, VSP_007051; Name=6; Synonyms=delE2; IsoId=P35240-6; Sequence=VSP_007040, VSP_007050, VSP_007051; Name=7; Synonyms=MER150; IsoId=P35240-7; Sequence=VSP_007045, VSP_007046; Name=8; IsoId=P35240-8; Sequence=VSP_007048, VSP_007050, VSP_007051; Name=9; Synonyms=MER162; IsoId=P35240-9; Sequence=VSP_007044; Name=10; Synonyms=MER151; IsoId=P35240-10; Sequence=VSP_007041, VSP_007043, VSP_007047, VSP_007049

Alternative Sequence

39..121; Missing (in isoform 4 and isoform 10); 39..80; Missing (in isoform 6); 81..121; Missing (in isoform 5); 150..579; Missing (in isoform 9); 150..225; Missing (in isoform 10); 259; N -> R (in isoform 7); 260..595; Missing (in isoform 7); 334..379; MERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEE -> GQRGRSAEAGPAGSTRGGAKSQAEAPGDCHQAHVPAHEPNSSTVAS (in isoform 10); 335..363; Missing (in isoform 8); 380..595; Missing (in isoform 10); 580..595; LTLQSAKSRVAFFEEL -> SSPRQKTYLHLSPQSRLFPGTLYVVMLYVVMVLPSVILTRA (in isoform 2); 580..590; LTLQSAKSRVA -> PQAQGRRPICI (in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8); 591..595; Missing (in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8)

3D Structural Models

Turn

81..83; 155..157; 160..165; 195..197; 215..218

Helix

43..54; 59..61; 105..108; 112..127; 135..150; 171..174; 181..194; 200..211; 258..260; 290..309; 316..336; 513..547; 552..554; 557..562; 573..581; 585..594

Beta Strand

24..27; 32..35; 62..70; 72..74; 77..80; 84..86; 90..100; 220..226; 231..236; 238..244; 249..251; 253..257; 261..267; 270..277; 283..286

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Domain (FT)

22..311; FERM

Clinical Relevance6

Disease Involvement (4)

Cancer-related genesDeafnessDisease variantTumor suppressor

Drugs (13)

SELUMETINIB IMATINIB EVEROLIMUS CETUXIMAB AR-42 NULL CISPLATIN LAPATINIB TEMSIROLIMUS BEVACIZUMAB-AWWB ERLOTINIB CARBOPLATIN OCTREOTIDE ACETATE

Antibody (2)

HPA003097 CAB005385

Interaction Protein (5)

ENSG00000004487ENSG00000118579ENSG00000126016ENSG00000131023ENSG00000185359

Interaction Count

5

Interaction Dataset

intact_biogrid

Supporting Publications1

PMID	Title	Abstract
37432984	Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis.	ENG expression was found to be upregulated in both human MPNST tumor tissues and plasma-circulating small extracellular vesicles.

Entry name MERL	UniProt ID P35240	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins