Protein detail

MERL

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)

Entry name MERL	UniProt ID P35240	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)

Protein Class

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Ensembl

ENSG00000186575

Entrez Gene Symbol

NF2

Gene Synonym

ACNBANFmerlinmerlin-1SCH

Gene Description

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

Chromosome

Position

29603556-29698598

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

26 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NF2	PRKACA	P17612	S	10	phosphorylation	PhosphoSite_MIMPMIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	SIGNOR:18071304 KEA:18071304 ProtMapper:18071304
NF2	PRKACA	P17612	S	518	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:17998937 KEA:15378014 SIGNOR:18071304 ProtMapper:18071304
NF2	NEDD4L	Q96PU5	K	396	ubiquitination	SIGNOR	SIGNOR:33058421
NF2	AKT1	P31749	S	315	phosphorylation	RLIMS-P_ProtMapperPhosphoSitePhosphoSite_ProtMapperProtMapper	ProtMapper:17891137
NF2	AKT1	P31749	T	230	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
NF2	AKT1	P31749	S	518	phosphorylation	PhosphoSite
NF2	AKT1	P31749	S	10	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper
NF2	AKT2	P31751	S	10	phosphorylation	PhosphoSite
NF2	AKT3	Q9Y243	S	10	phosphorylation	PhosphoSite
NF2	PRKX	P51817	S	518	phosphorylation	MIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP

Page 2 of 3Previous Next

Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
transmembrane_predicted	transmembrane	OmniPath	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No

Page 1 of 2Next

Regulatory Interaction Network

13 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MERL	P35240	STK3	Q13188	Yes	Yes	No	SIGNOR	SIGNOR:27402866
DCAF1	Q9Y4B6	MERL	P35240	Yes	No	Yes	HPRDHINTLit-BM-17SIGNOR	Lit-BM-17:21750658 Lit-BM-17:24912773 SIGNOR:18332868 Lit-BM-17:18332868 HINT:24912773 HINT:18332868 Lit-BM-17:26549023 HINT:21750658 HPRD:18332868 Lit-BM-17:20178741
TNIK	Q9UKE5	MERL	P35240	Yes	Yes	No	REACH_ProtMapperSIGNORProtMapper	SIGNOR:33495197 ProtMapper:33495197
MERL	P35240	LATS1	O95835	Yes	Yes	No	HINTLit-BM-17SIGNOR	HINT:34337379 Lit-BM-17:26045165 HINT:24012335 HINT:26045165 Lit-BM-17:24012335 SIGNOR:24012335
	COMPLEX:P62877_Q13619_Q16531_Q96SW2	MERL	P35240	Yes	No	Yes	SIGNOR	SIGNOR:18332868
MERL	P35240	STK4	Q13043	Yes	Yes	No	SIGNOR	SIGNOR:27402866
PP1B	P62140	MERL	P35240	Yes	Yes	No	SIGNOR_ProtMapperSIGNORProtMapper	SIGNOR:18071304 ProtMapper:18071304
KAPCA	P17612	MERL	P35240	Yes	Yes	Yes	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPNCI-PID_ProtMapperHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEASIGNOR_ProtMapperPhosphoSite_ProtMapper	KEA:15378014 ProtMapper:17998937 KEA:18071304 ProtMapper:18071304 SIGNOR:18071304
PAK1	Q13153	MERL	P35240	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperHINTPhosphoSite_KEAdbPTMInnateDBHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapperAdhesomeHPRD-phos	Adhesome:14580336 HPRD-phos:18669648 HPRD-phos:19691289 ProtMapper:27285107 ProtMapper:25893302 ProtMapper:18071304 SIGNOR:18071304 ProtMapper:19165420 HINT:11719502 ProtMapper:23162742 ProtMapper:28090172 KEA:17081983 HPRD-phos:20068231 ProtMapper:20302846 KEA:11782491 dbPTM:18669648 KEA:14981079 KEA:15378014 HPRD:14580336 ProtMapper:22567403 HINT:14580336 dbPTM:17081983 ProtMapper:31652973 HPRD-phos:11719502 ProtMapper:19651622 KEA:11719502 ProtMapper:27345717 ProtMapper:18835652 ProtMapper:11719502 ProtMapper:19691289 ProtMapper:26555075 ProtMapper:22105362 InnateDB:11719502 HPRD:11719502 HINT:21481793 Adhesome:21481793 ProtMapper:19036346 Adhesome:11719502 ProtMapper:20068231 ProtMapper:18669648 HPRD-phos:19651622
NED4L	Q96PU5	MERL	P35240	Yes	Yes	No	SIGNOR	SIGNOR:33058421

Page 1 of 2Next

Protein Complex Composition

216 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
MLL1 complex	ASH2L BACC1 CHD8 E2F6 HCFC1 INO80C KANSL1 KAT8 KMT2A LAS1L MAX MCRS1 MGA PELP1 PHF20 PRPF31 RBBP5 RNF2 RUVBL1 RUVBL2 SENP3 TAF1 TAF4 TAF6 TAF7 TAF9 TEX10 WDR5	O00268 O75461 P21675 P49848 P51610 P61244 P61964 Q03164 Q15291 Q15545 Q16594 Q6PI98 Q7Z3B3 Q8IWI9 Q8IXM2 Q8IZL8 Q8WWY3 Q96EZ8 Q99496 Q9BVI0 Q9H4L4 Q9H7Z6 Q9HCK8 Q9NXF1 Q9UBL3 Q9Y230 Q9Y265 Q9Y4W2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1278	15960975
MLL1-WDR5	ASH2L BACC1 CHD8 E2F6 HCFC1 HSPA4 INO80C KANSL1 KAT8 KMT2A LAS1L MAX MCRS1 MGA PELP1 PHF20 PRPF31 RBBP5 RNF2 RUVBL1 RUVBL2 SENP3 TAF1 TAF4 TAF6 TAF7 TAF9 TEX10 WDR5	O00268 O75461 P21675 P34932 P49848 P51610 P61244 P61964 Q03164 Q15291 Q15545 Q16594 Q6PI98 Q7Z3B3 Q8IWI9 Q8IXM2 Q8IZL8 Q8WWY3 Q96EZ8 Q99496 Q9BVI0 Q9H4L4 Q9H7Z6 Q9HCK8 Q9NXF1 Q9UBL3 Q9Y230 Q9Y265 Q9Y4W2	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC1045	15960975
NF2-WWC1 complex	NF2 WWC1	P35240 Q8IX03	0:0	CORUM	CORUM:6617	20159599
Non-canonical polycomb repressive complex 1.1RING2-PCGF1-RYBP variant	BCORL1 KDM2B PCGF1 RNF2 RYBP SKP1	P63208 Q5H9F3 Q8N488 Q8NHM5 Q99496 Q9BSM1	1:1:1:1:1:1	ComplexPortal	PDB:3IXSintact:EBI-9021396PDB:4HPMPDB:5JH5	22325352 14755292 27568929 33202645 34680880
Non-canonical polycomb repressive complex 1.1RING2-PCGF1-YAF2 variant	BCOR KDM2B PCGF1 RNF2 SKP1 YAF2	P63208 Q6W2J9 Q8IY57 Q8NHM5 Q99496 Q9BSM1	1:1:1:1:1:1	ComplexPortal	intact:EBI-9011118PDB:5JH5PDB:4HPM	22325352 14755292 27568929 33202645 34680880
Non-canonical polycomb repressive complex 1.2RNF2-RYBP variant	PCGF2 RNF2 RYBP	P35227 Q8N488 Q99496	1:1:1	ComplexPortal	intact:EBI-9011197	22325352 14755292 33202645
Non-canonical polycomb repressive complex 1.2RNF2-YAF2 variant	PCGF2 RNF2 YAF2	P35227 Q8IY57 Q99496	1:1:1	ComplexPortal	intact:EBI-9011245	22325352 14755292 33202645
Non-canonical polycomb repressive complex 1.4RNF2-RYBP variant	BMI1 RNF2 RYBP	P35226 Q8N488 Q99496	1:1:1	ComplexPortal	PDB:3IXSintact:EBI-9020110	22325352 14755292 33202645
Non-canonical polycomb repressive complex 1.4RNF2-YAF2 variant	BMI1 RNF2 YAF2	P35226 Q8IY57 Q99496	1:1:1	ComplexPortal	intact:EBI-9011273	22325352 14755292 33202645
Noncanonical PRC1	BCOR PCGF1 RNF2 SKP1	P63208 Q6W2J9 Q99496 Q9BSM1	0:0:0:0	SIGNOR	SIGNOR:SIGNOR-C151

Page 2 of 22Previous Next

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	40326690

Sequence, Structure & Domains

Sequences

Length

595

Mass

69,690

Sequence

MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL

Alternative Products

Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=I; IsoId=P35240-1; Sequence=Displayed; Name=2; IsoId=P35240-2; Sequence=VSP_000492; Name=3; Synonyms=II; IsoId=P35240-3; Sequence=VSP_007050, VSP_007051; Name=4; Synonyms=delE2/3; IsoId=P35240-4; Sequence=VSP_007041, VSP_007050, VSP_007051; Name=5; Synonyms=delE3; IsoId=P35240-5; Sequence=VSP_007042, VSP_007050, VSP_007051; Name=6; Synonyms=delE2; IsoId=P35240-6; Sequence=VSP_007040, VSP_007050, VSP_007051; Name=7; Synonyms=MER150; IsoId=P35240-7; Sequence=VSP_007045, VSP_007046; Name=8; IsoId=P35240-8; Sequence=VSP_007048, VSP_007050, VSP_007051; Name=9; Synonyms=MER162; IsoId=P35240-9; Sequence=VSP_007044; Name=10; Synonyms=MER151; IsoId=P35240-10; Sequence=VSP_007041, VSP_007043, VSP_007047, VSP_007049

Alternative Sequence

39..121; Missing (in isoform 4 and isoform 10); 39..80; Missing (in isoform 6); 81..121; Missing (in isoform 5); 150..579; Missing (in isoform 9); 150..225; Missing (in isoform 10); 259; N -> R (in isoform 7); 260..595; Missing (in isoform 7); 334..379; MERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEE -> GQRGRSAEAGPAGSTRGGAKSQAEAPGDCHQAHVPAHEPNSSTVAS (in isoform 10); 335..363; Missing (in isoform 8); 380..595; Missing (in isoform 10); 580..595; LTLQSAKSRVAFFEEL -> SSPRQKTYLHLSPQSRLFPGTLYVVMLYVVMVLPSVILTRA (in isoform 2); 580..590; LTLQSAKSRVA -> PQAQGRRPICI (in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8); 591..595; Missing (in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8)

3D Structural Models

Turn

81..83; 155..157; 160..165; 195..197; 215..218

Helix

43..54; 59..61; 105..108; 112..127; 135..150; 171..174; 181..194; 200..211; 258..260; 290..309; 316..336; 513..547; 552..554; 557..562; 573..581; 585..594

Beta Strand

24..27; 32..35; 62..70; 72..74; 77..80; 84..86; 90..100; 220..226; 231..236; 238..244; 249..251; 253..257; 261..267; 270..277; 283..286

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Domain (FT)

22..311; FERM

Clinical Relevance

Disease Involvement

Cancer-related genesDeafnessDisease variantTumor suppressor

Drugs

SELUMETINIB IMATINIB EVEROLIMUS CETUXIMAB AR-42 NULL CISPLATIN LAPATINIB TEMSIROLIMUS BEVACIZUMAB-AWWB ERLOTINIB CARBOPLATIN OCTREOTIDE ACETATE

Antibody

HPA003097 CAB005385

Interaction Protein

ENSG00000004487ENSG00000118579ENSG00000126016ENSG00000131023ENSG00000185359

Interaction Count

Interaction Dataset

intact_biogrid