Protein detail

MERL

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)

Entry name MERL	UniProt ID P35240	EVMP score 0.50
Frequency 1	Transmembrane count	Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Merlin (Moesin-ezrin-radixin-like protein) (Neurofibromin-2) (Schwannomerlin) (Schwannomin)

Protein Class

Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Ensembl

ENSG00000186575

Entrez Gene Symbol

NF2

Gene Synonym

ACNBANFmerlinmerlin-1SCH

Gene Description

NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

Chromosome

Position

29603556-29698598

Frequency

EVMP Score

0.50

Fluorescence & Localization

Cell SpecificEpicardial cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificnaive B-cellBlood Lineage SpecificB-cellsSecretome LocationSecreted to bloodSecretome FunctionReceptor

Function & Pathway

Protein Function

Human disease related genes:Cancers:Cancers of the lung and pleura
Human disease related genes:Cancers:Cancers of eye, brain, and central nervous system
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes:Congenital malformations:Other congenital malformations

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

26 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
NF2	PAK2	Q13177	S	518	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:15378014 ProtMapper:28007610 KEA:17081983 ProtMapper:11782491 ProtMapper:20302846 KEA:11782491 KEA:11719502 phosphoELM:15378014 ProtMapper:15378014 KEA:14981079 SIGNOR:18071304 ProtMapper:18071304
NF2	PAK2	Q13177	S	435	phosphorylation	KEA	KEA:15378014 KEA:17081983 KEA:11782491 KEA:11719502 KEA:14981079
NF2	PAK2	Q13177	S	476	phosphorylation	KEA	KEA:15378014 KEA:17081983 KEA:11782491 KEA:11719502 KEA:14981079
NF2	PAK2	Q13177	S	477	phosphorylation	KEA	KEA:15378014 KEA:17081983 KEA:11782491 KEA:11719502 KEA:14981079
NF2	PAK1	Q13153	S	518	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDRLIMS-P_ProtMapperdbPTMKEASIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper	HPRD:18669648 ProtMapper:27285107 ProtMapper:25893302 ProtMapper:18071304 SIGNOR:18071304 ProtMapper:19165420 ProtMapper:23162742 ProtMapper:28090172 KEA:17081983 ProtMapper:20302846 KEA:11782491 dbPTM:18669648 KEA:14981079 KEA:15378014 ProtMapper:22567403 dbPTM:17081983 HPRD:19651622 HPRD:20068231 HPRD:19691289 KEA:11719502 ProtMapper:27345717 ProtMapper:26555075 ProtMapper:22105362 HPRD:11719502 ProtMapper:19036346
NF2	PAK1	Q13153	S	476	phosphorylation	HPRDKEA	HPRD:11719502 KEA:15378014 HPRD:19651622 HPRD:20068231 KEA:17081983 HPRD:19691289 HPRD:18669648 KEA:11719502 KEA:11782491 KEA:14981079
NF2	PAK1	Q13153	S	477	phosphorylation	HPRDKEA	HPRD:11719502 KEA:15378014 HPRD:19651622 HPRD:20068231 KEA:17081983 HPRD:19691289 HPRD:18669648 KEA:11719502 KEA:11782491 KEA:14981079
NF2	PAK1	Q13153	S	435	phosphorylation	HPRDKEA	HPRD:11719502 KEA:15378014 HPRD:19651622 HPRD:20068231 KEA:17081983 HPRD:19691289 HPRD:18669648 KEA:11719502 KEA:11782491 KEA:14981079
NF2	PPP1CB	P62140	S	518	dephosphorylation	SIGNOR	SIGNOR:18071304
NF2	PPP1CB	P62140	S	518	phosphorylation	SIGNOR_ProtMapperProtMapper	ProtMapper:18071304

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Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane_phobius	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_sosui	transmembrane_predicted	Almen2009	No	No	No	No	No
transmembrane_tmhmm	transmembrane_predicted	Almen2009	No	No	No	No	No

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Regulatory Interaction Network

13 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
MERL	P35240	LATS2	Q9NRM7	Yes	Yes	No	HINTLit-BM-17SIGNOR	Lit-BM-17:26045165 HINT:26045165 Lit-BM-17:24012335 SIGNOR:24012335
PAK2	Q13177	MERL	P35240	Yes	Yes	Yes	HPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperPhosphoSite_KEAphosphoELM_KEAInnateDBKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperSparser_ProtMapper	InnateDB:11719502 KEA:15378014 ProtMapper:28007610 KEA:17081983 ProtMapper:11782491 ProtMapper:20302846 KEA:11782491 KEA:11719502 phosphoELM:15378014 ProtMapper:15378014 KEA:14981079 SIGNOR:18071304 ProtMapper:18071304
AKT1	P31749	MERL	P35240	Yes	No	No	AdhesomePhosphoSite_norefiPTMnetProtMapperRLIMS-P_ProtMapperHINTPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:21722762 PhosphoSite:26506913 PhosphoSite:11782491 PhosphoSite:14981079 PhosphoSite:18835652 PhosphoSite:32115406 HINT:21750658 PhosphoSite:18071304 PhosphoSite:15743831 PhosphoSite:11719502 PhosphoSite:11703924 PhosphoSite:17175165 PhosphoSite:22673903 Adhesome:17891137 PhosphoSite:24166499 PhosphoSite:19691289 PhosphoSite:27285107 PhosphoSite:14724586 PhosphoSite:25925953 PhosphoSite:20178741 PhosphoSite:21750658 PhosphoSite:33058421 PhosphoSite:22516197 PhosphoSite:16267393 PhosphoSite:19651622 PhosphoSite:16652148 PhosphoSite:21857030 PhosphoSite:17566081 PhosphoSite:26997273 PhosphoSite:15378014 PhosphoSite:20860994 PhosphoSite:28273460 ProtMapper:17891137 HINT:17891137 PhosphoSite:17891137

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Protein Complex Composition

216 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Polycomb repressive complex 1RING2-PCGF2-CBX2-PHC3 variant	CBX2 PCGF2 PHC3 RNF2	P35227 Q14781 Q8NDX5 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34603933	22325352 34009336 28087428 14755292 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX4-PHC1 variant	CBX4 PCGF2 PHC1 RNF2	O00257 P35227 P78364 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34603974	26711500 22325352 34009336 28087428 14755292 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX4-PHC2 variant	CBX4 PCGF2 PHC2 RNF2	O00257 P35227 Q8IXK0 Q99496	1:1:1:1	ComplexPortal		26711500 22325352 34009336 28087428 14755292 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX4-PHC3 variant	CBX4 PCGF2 PHC3 RNF2	O00257 P35227 Q8NDX5 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604017	26711500 22325352 34009336 28087428 14755292 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX6-PHC1 variant	CBX6 PCGF2 PHC1 RNF2	O95503 P35227 P78364 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604108	33202645 26711500 34009336 28087428 14755292 29089522 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX6-PHC2 variant	CBX6 PCGF2 PHC2 RNF2	O95503 P35227 Q8IXK0 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604151	33202645 26711500 34009336 28087428 14755292 29089522 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX6-PHC3 variant	CBX6 PCGF2 PHC3 RNF2	O95503 P35227 Q8NDX5 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604195	26711500 22325352 34009336 28087428 14755292 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX7-PHC1 variant	CBX7 PCGF2 PHC1 RNF2	O95931 P35227 P78364 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604241PDB:3GS2	20696397 34009336 28087428 14755292 34659360 33202645 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX7-PHC2 variant	CBX7 PCGF2 PHC2 RNF2	O95931 P35227 Q8IXK0 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604282PDB:3GS2	20696397 34009336 14755292 34659360 33202645 34680880
Polycomb repressive complex 1RING2-PCGF2-CBX7-PHC3 variant	CBX7 PCGF2 PHC3 RNF2	O95931 P35227 Q8NDX5 Q99496	1:1:1:1	ComplexPortal	intact:EBI-34604322PDB:3GS2	20696397 34009336 28087428 14755292 34659360 33202645 34680880

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Mass spectrometry	1	40326690

Sequence, Structure & Domains

Sequences

Length

595

Mass

69,690

Sequence

MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL

Alternative Products

Event=Alternative splicing; Named isoforms=10; Name=1; Synonyms=I; IsoId=P35240-1; Sequence=Displayed; Name=2; IsoId=P35240-2; Sequence=VSP_000492; Name=3; Synonyms=II; IsoId=P35240-3; Sequence=VSP_007050, VSP_007051; Name=4; Synonyms=delE2/3; IsoId=P35240-4; Sequence=VSP_007041, VSP_007050, VSP_007051; Name=5; Synonyms=delE3; IsoId=P35240-5; Sequence=VSP_007042, VSP_007050, VSP_007051; Name=6; Synonyms=delE2; IsoId=P35240-6; Sequence=VSP_007040, VSP_007050, VSP_007051; Name=7; Synonyms=MER150; IsoId=P35240-7; Sequence=VSP_007045, VSP_007046; Name=8; IsoId=P35240-8; Sequence=VSP_007048, VSP_007050, VSP_007051; Name=9; Synonyms=MER162; IsoId=P35240-9; Sequence=VSP_007044; Name=10; Synonyms=MER151; IsoId=P35240-10; Sequence=VSP_007041, VSP_007043, VSP_007047, VSP_007049

Alternative Sequence

39..121; Missing (in isoform 4 and isoform 10); 39..80; Missing (in isoform 6); 81..121; Missing (in isoform 5); 150..579; Missing (in isoform 9); 150..225; Missing (in isoform 10); 259; N -> R (in isoform 7); 260..595; Missing (in isoform 7); 334..379; MERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEE -> GQRGRSAEAGPAGSTRGGAKSQAEAPGDCHQAHVPAHEPNSSTVAS (in isoform 10); 335..363; Missing (in isoform 8); 380..595; Missing (in isoform 10); 580..595; LTLQSAKSRVAFFEEL -> SSPRQKTYLHLSPQSRLFPGTLYVVMLYVVMVLPSVILTRA (in isoform 2); 580..590; LTLQSAKSRVA -> PQAQGRRPICI (in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8); 591..595; Missing (in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 8)

3D Structural Models

Turn

81..83; 155..157; 160..165; 195..197; 215..218

Helix

43..54; 59..61; 105..108; 112..127; 135..150; 171..174; 181..194; 200..211; 258..260; 290..309; 316..336; 513..547; 552..554; 557..562; 573..581; 585..594

Beta Strand

24..27; 32..35; 62..70; 72..74; 77..80; 84..86; 90..100; 220..226; 231..236; 238..244; 249..251; 253..257; 261..267; 270..277; 283..286

3D Structure

X-ray crystallography (6)

Domain & Motif Annotations

Domain (FT)

22..311; FERM

Clinical Relevance

Disease Involvement

Cancer-related genesDeafnessDisease variantTumor suppressor

Drugs

SELUMETINIB IMATINIB EVEROLIMUS CETUXIMAB AR-42 NULL CISPLATIN LAPATINIB TEMSIROLIMUS BEVACIZUMAB-AWWB ERLOTINIB CARBOPLATIN OCTREOTIDE ACETATE

Antibody

HPA003097 CAB005385

Interaction Protein

ENSG00000004487ENSG00000118579ENSG00000126016ENSG00000131023ENSG00000185359

Interaction Count

Interaction Dataset

intact_biogrid