EV MemProt Atlas

Basic Information

Protein Names

Radixin

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Ensembl

ENSG00000137710

Entrez Gene Symbol

RDX

Gene Synonym

DFNB24

Gene Description

Radixin

Chromosome

11

Position

109864295-110296712

Frequency

13

EVMP Score

0.72

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted to bloodSecretome FunctionEnzyme inhibitor

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

13 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
RDX	ROCK1	Q13464	T	573	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	ProtMapper:9456324 KEA:9456324 SIGNOR:9456324
RDX	ROCK1	Q13464	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:9456324 HPRD:20068231 HPRD:9456324 ProtMapper:9456324 KEA:17447891 SIGNOR:9456324
RDX	RHOA	P61586	T	564	phosphorylation	SIGNOR	SIGNOR:35267019
RDX	PRKCQ	Q04759	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
RDX	SLK	Q9H2G2	T	564	phosphorylation	PhosphoSite
RDX	LRRK2	Q5S007	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:17447891
RDX	GRK2	P25098	T	564	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21903131 ProtMapper:19913059
RDX	STK10	O94804	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
RDX	MAP3K8	P41279	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
RDX	MAP4K4	O95819	T	564	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

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Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	MatrixDB	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ferm_domain	intracellular_intercellular_related	HGNC	Yes	No	No	No	No
adhesion_cytoskeleton_adaptor	intracellular_intercellular_related	Adhesome	Yes	No	No	No	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ROCK1	Q13464	RADI	P35241	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperAdhesomeACSNHPRD-phos	SIGNOR:9456324 HPRD-phos:9456324 KEA:17447891 KEA:9456324 Adhesome:9456324 ACSN:10970850 ACSN:10047517 HPRD:9456324 ProtMapper:20068231 HPRD-phos:20068231 ACSN:8522586 ProtMapper:9456324 ACSN:8527459 ACSN:9287351 ACSN:12778124 ACSN:12802084 ACSN:12045227 ACSN:7579708
LRRK2	Q5S007	RADI	P35241	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEAPhosphoSite_ProtMapper	KEA:17447891 SIGNOR:17447891
RHOA	P61586	RADI	P35241	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:35267019 SIGNOR:35267019
VPS11	Q9H270	RADI	P35241	Yes	Yes	No	SIGNOR	SIGNOR:21148287

Protein Complex Composition

46 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
HT_DM_Cluster381	KLK11 KLK14 PRDX4	Q13162 Q9P0G3 Q9UBX7	1:1:1	Compleat	Compleat:HC570	22036573
Sulphiredoxin-peroxiredoxin complex	PRDX1 SRXN1	Q06830 Q9BYN0	2:2	CompleatCORUMPDB	PDB:3hy2PDB:7lj1PDB:2riiCompleat:HC1186CORUM:3151	18172504
	A6NL28 PRDX2 RRM1 SGSH	A6NL28 P23921 P32119 P51688	0:0:0:0	Havugimana2012	Havugimana2012:C_165
	ARL3 CACNA1A ERO1A ERO1B H2AX P4HB PDIA3 PDIA4 PRDX4 TXNDC5 UBC	O00555 P07237 P0CG48 P13667 P16104 P30101 P36405 Q13162 Q86YB8 Q8NBS9 Q96HE7	1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3817
	BIRC3 CHEK1 CPOX PRDX3 PRDX4 TWNK	O14757 P30048 P36551 Q13162 Q13489 Q96RR1	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7502
	CDC5L CYP3A5 DDX20 GEMIN2 GEMIN5 PRDX2 SFPQ SMN1 SNRNP70 SNRPA SNRPA1 SNRPD2 SNRPE SNRPF SNRPG	O14893 P08621 P09012 P09661 P20815 P23246 P32119 P62304 P62306 P62308 P62316 Q16637 Q8TEQ6 Q99459 Q9UHI6	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4449
	CHERP PRDX1 RBM10 RBM17 RBM5 U2SURP	O15042 P0DW28 P52756 Q06830 Q8IWX8 Q96I25	0:0:0:0:0:0	hu.MAP2
	CHERP PRDX1 RBM10 RBM17 RBM5 U2SURP	O15042 P52756 P98175 Q06830 Q8IWX8 Q96I25	0:0:0:0:0:0	hu.MAP2
	KPNA1 KPNA5 KPNA6 MTRR PRDX1 PRDX2 PRDX3 RNMT S100A10	O15131 O43148 O60684 P30048 P32119 P52294 P60903 Q06830 Q9UBK8	0:0:0:0:0:0:0:0:0	hu.MAP2
	GCK MTRR PRDX1 PRDX2 PRDX3 RNMT	O43148 P30048 P32119 P35557 Q06830 Q9UBK8	0:0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	37968711

Sequence, Structure & Domains

Sequences

Length

583

Mass

68,564

Sequence

MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P35241-1; Sequence=Displayed; Name=2; IsoId=P35241-2; Sequence=VSP_045315, VSP_045318; Name=3; IsoId=P35241-3; Sequence=VSP_045316, VSP_045317, VSP_045318; Name=4; IsoId=P35241-4; Sequence=VSP_047276; Name=5; IsoId=P35241-5; Sequence=VSP_045318

Alternative Sequence

1..347; Missing (in isoform 2); 1..156; MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQR -> MLSWNLPFSPIQLANNFLTS (in isoform 4); 33..64; Missing (in isoform 3); 168..539; Missing (in isoform 3); 583; M -> MWGPKLYALFQMRSCQSSIKQM (in isoform 2, isoform 3 and isoform 5)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

376..400; Basic and acidic residues; 469..480; Pro residues; 483..492; Basic and acidic residues; 506..525; Basic and acidic residues

Domain (CC)

The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity).

Domain (FT)

5..295; FERM

Region

310..330; Disordered; 376..407; Disordered; 462..526; Disordered

Clinical Relevance

Disease Involvement

DeafnessDisease variantNon-syndromic deafness

Antibody

HPA000263 HPA000763 CAB037312

Interaction Protein

ENSG00000092820ENSG00000141522

Interaction Count

2

Interaction Dataset

intact_biogrid_bioplexintact_biogrid

Protein symbol RADI	UniProt ID P35241	EVMP score 0.72
Frequency 13	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

RADI