EV MemProt Atlas

Basic Information

Protein Names

Radixin

Protein Class

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Ensembl

ENSG00000137710

Entrez Gene Symbol

RDX

Gene Synonym

DFNB24

Gene Description

Radixin

Chromosome

11

Position

109864295-110296712

Frequency

13

EVMP Score

0.72

Fluorescence & Localization

Tissue SpecificesophagusCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted to bloodSecretome FunctionEnzyme inhibitor

Function & Pathway

Protein Function

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Ear disease

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

13 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
RDX	ROCK1	Q13464	T	573	phosphorylation	phosphoELM_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper	ProtMapper:9456324 KEA:9456324 SIGNOR:9456324
RDX	ROCK1	Q13464	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:9456324 HPRD:20068231 HPRD:9456324 ProtMapper:9456324 KEA:17447891 SIGNOR:9456324
RDX	RHOA	P61586	T	564	phosphorylation	SIGNOR	SIGNOR:35267019
RDX	PRKCQ	Q04759	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
RDX	SLK	Q9H2G2	T	564	phosphorylation	PhosphoSite
RDX	LRRK2	Q5S007	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperKEAPhosphoSitePhosphoSite_ProtMapper	KEA:17447891
RDX	GRK2	P25098	T	564	phosphorylation	Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:21903131 ProtMapper:19913059
RDX	STK10	O94804	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
RDX	MAP3K8	P41279	T	564	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper
RDX	MAP4K4	O95819	T	564	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

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Ligand-Receptor Signaling

13 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular_intercellular_related	intracellular_intercellular_related	OmniPath	Yes	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No

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Regulatory Interaction Network

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
ROCK1	Q13464	RADI	P35241	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperAdhesomeACSNHPRD-phos	SIGNOR:9456324 HPRD-phos:9456324 KEA:17447891 KEA:9456324 Adhesome:9456324 ACSN:10970850 ACSN:10047517 HPRD:9456324 ProtMapper:20068231 HPRD-phos:20068231 ACSN:8522586 ProtMapper:9456324 ACSN:8527459 ACSN:9287351 ACSN:12778124 ACSN:12802084 ACSN:12045227 ACSN:7579708
LRRK2	Q5S007	RADI	P35241	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEAPhosphoSite_ProtMapper	KEA:17447891 SIGNOR:17447891
RHOA	P61586	RADI	P35241	Yes	Yes	No	SIGNOR_ProtMapperiPTMnetSIGNORProtMapper	ProtMapper:35267019 SIGNOR:35267019
VPS11	Q9H270	RADI	P35241	Yes	Yes	No	SIGNOR	SIGNOR:21148287

Protein Complex Composition

46 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
ALG12 H2AX PRDX2 PRDX3 PRDX4 SUMO4 UBC	P0CG48 P16104 P30048 P32119 Q13162 Q6EEV6 Q9BV10	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC8857
DUSP23 H2AX PRDX2 PRDX3 PRDX4 SUMO4 UBC	P0CG48 P16104 P30048 P32119 Q13162 Q6EEV6 Q9BVJ7	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4181
ACSM2B PRDX2 PRDX3 PRDX4 SUMO4 UBC	P0CG48 P30048 P32119 Q13162 Q68CK6 Q6EEV6	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC4269
ACLY PKM PRDX2	P14618 P32119 P53396	0:0:0	hu.MAP2
DUSP23 H2AC20 H2AX H2BC14 H3C11 H4C4 KAT5 NAP1L5 PRDX4 RCC1 SSRP1 SUPT16H	P16104 P18754 P62805 P68431 Q08945 Q13162 Q16777 Q92993 Q96NT1 Q99879 Q9BVJ7 Q9Y5B9	1:1:2:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7578
DTYMK PRDX1 PRDX2 TTN	P23919 P32119 Q06830 Q8WZ42	0:0:0:0	hu.MAP
PRDX5	P30044	8	PDB	PDB:2vl9PDB:1h4oPDB:2vl3PDB:1oc3PDB:2vl2PDB:4k7oPDB:4k7iPDB:4k7nPDB:4mmm
PRDX5 SPR	P30044 P35270	0:0	hu.MAP
IFT27 PRDX5 PTGR1 SUMO1	P30044 P63165 Q14914 Q9BW83	0:0:0:0	Havugimana2012	Havugimana2012:C_303
BOLA3 C11orf54 FAHD2A FAHD2B PRDX5	P30044 Q53S33 Q6P2I3 Q96GK7 Q9H0W9	0:0:0:0:0	hu.MAP2

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	1	37968711

Sequence, Structure & Domains

Sequences

Length

583

Mass

68,564

Sequence

MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM

Alternative Products

Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P35241-1; Sequence=Displayed; Name=2; IsoId=P35241-2; Sequence=VSP_045315, VSP_045318; Name=3; IsoId=P35241-3; Sequence=VSP_045316, VSP_045317, VSP_045318; Name=4; IsoId=P35241-4; Sequence=VSP_047276; Name=5; IsoId=P35241-5; Sequence=VSP_045318

Alternative Sequence

1..347; Missing (in isoform 2); 1..156; MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQR -> MLSWNLPFSPIQLANNFLTS (in isoform 4); 33..64; Missing (in isoform 3); 168..539; Missing (in isoform 3); 583; M -> MWGPKLYALFQMRSCQSSIKQM (in isoform 2, isoform 3 and isoform 5)

3D Structural Models

Domain & Motif Annotations

Compositional Bias

376..400; Basic and acidic residues; 469..480; Pro residues; 483..492; Basic and acidic residues; 506..525; Basic and acidic residues

Domain (CC)

The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity).

Domain (FT)

5..295; FERM

Region

310..330; Disordered; 376..407; Disordered; 462..526; Disordered

Clinical Relevance

Disease Involvement

DeafnessDisease variantNon-syndromic deafness

Antibody

HPA000263 HPA000763 CAB037312

Interaction Protein

ENSG00000092820ENSG00000141522

Interaction Count

2

Interaction Dataset

intact_biogrid_bioplexintact_biogrid

Protein symbol RADI	UniProt ID P35241	EVMP score 0.72
Frequency 13	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

RADI