Protein detail
RADI
Radixin
Entry name RADI | UniProt ID | EVMP confidence score 0.60 |
Supporting publications (n) 13 | Transmembrane count | Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Radixin
Protein Class (3)
Disease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Ensembl
Entrez Gene Symbol
Gene Synonym
DFNB24
Gene Description
Radixin
Chromosome
11
Position
109864295-110296712
Supporting publications (n)
13
EVMP confidence score
0.60
Fluorescence & Localization
Tissue SpecificesophagusCell SpecificCytotrophoblastsSingle-Nuclei Brain Specificcentral nervous system macrophageSecretome LocationSecreted to bloodSecretome FunctionEnzyme inhibitor
Function & Pathway
Protein Function (3)
- Disease related genes
- Predicted intracellular proteins
- Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (17)
- GO:0005615 extracellular space
- GO:0005886 plasma membrane
- GO:0005902 microvillus
- GO:0005912 adherens junction
- GO:0005925 focal adhesion
- GO:0016324 apical plasma membrane
- GO:0030027 lamellipodium
- GO:0030175 filopodium
- GO:0030315 T-tubule
- GO:0030496 midbody
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Molecular Function (7)
Biological Process (3)
KEGG (5)
Reactome (6)
Mediation Categories (3)
Adhesion and uptake mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence77
Enzyme-Mediated Modification (13)
13 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| RDX | ROCK2 | O75116 | T | 564 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPKEA | KEA:9456324 |
| RDX | ROCK2 | O75116 | T | 573 | phosphorylation | MIMPHPRD_MIMPKEAphosphoELM_MIMP | KEA:9456324 |
| RDX | PRKCA | P17252 | T | 564 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling (13)
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | MatrixDB | Yes | ||||
| ecm | ecm | OmniPath | Yes | ||||
| extracellular | extracellular | OmniPath | |||||
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| ferm_domain | intracellular_intercellular_related | HGNC | Yes | ||||
| adhesion_cytoskeleton_adaptor | intracellular_intercellular_related | Adhesome | Yes |
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Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ROCK1 | Q13464 | RADI | P35241 | Yes | Yes | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAHPRDKinexus_KEAWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperAdhesomeACSNHPRD-phos | SIGNOR:9456324HPRD-phos:9456324KEA:17447891KEA:9456324Adhesome:9456324ACSN:10970850ACSN:10047517HPRD:9456324ProtMapper:20068231HPRD-phos:20068231ACSN:8522586ProtMapper:9456324ACSN:8527459ACSN:9287351ACSN:12778124ACSN:12802084ACSN:12045227ACSN:7579708 | |
| LRRK2 | Q5S007 | RADI | P35241 | Yes | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperKEAKinexus_KEAPhosphoSite_ProtMapper | KEA:17447891SIGNOR:17447891 | |
| RHOA | P61586 | RADI | P35241 | Yes | Yes | SIGNOR_ProtMapperiPTMnetSIGNORProtMapper | ProtMapper:35267019SIGNOR:35267019 | |
| VPS11 | Q9H270 | RADI | P35241 | Yes | Yes | SIGNOR | SIGNOR:21148287 |
Protein Complex Composition (46)
46 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GRHPRPRDX5 | P30044Q9UBQ7 | 0:0 | hu.MAP | |||
| PRDX3 | P30048 | 9 | PDB | PDB:5jcgPDB:5ucx | ||
| PRDX2PRDX3 | P30048P32119 | 0:0 | hu.MAP | |||
| PRDX1PRDX2PRDX3 | P30048P32119Q06830 | 0:0:0 | hu.MAP2 | |||
| GCKMTRRPRDX3PUS7 | P30048P35557Q96PZ0Q9UBK8 | 0:0:0:0 | hu.MAP2 | |||
| BIRC3CPOXPRDX3PRDX4SLC25A3TWNK | P30048P36551Q00325Q13162Q13489Q96RR1 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC6998 | ||
| BIRC3CPOXPDIA6PRDX3PRDX4TWNK | P30048P36551Q13162Q13489Q15084Q96RR1 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC8445 | ||
| PRDX2 | P32119 | 10 | PDB | PDB:7kj0PDB:7kj1PDB:5b8aPDB:5b8bPDB:5ijtPDB:1qmvPDB:7kiz | ||
| ALDH1L2DAZAP1PRDX1PRDX2TTN | P32119Q06830Q3SY69Q8WZ42Q96EP5 | 0:0:0:0:0 | hu.MAP | |||
| RDXTKTL2 | P35241Q9H0I9 | 0:0 | hu.MAP |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37968711 |
Sequence, Structure & Domains
Sequences
Length
583
Mass
68,564
Sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
Alternative Products
Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=P35241-1; Sequence=Displayed; Name=2; IsoId=P35241-2; Sequence=VSP_045315, VSP_045318; Name=3; IsoId=P35241-3; Sequence=VSP_045316, VSP_045317, VSP_045318; Name=4; IsoId=P35241-4; Sequence=VSP_047276; Name=5; IsoId=P35241-5; Sequence=VSP_045318
Alternative Sequence
1..347; Missing (in isoform 2); 1..156; MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQR -> MLSWNLPFSPIQLANNFLTS (in isoform 4); 33..64; Missing (in isoform 3); 168..539; Missing (in isoform 3); 583; M -> MWGPKLYALFQMRSCQSSIKQM (in isoform 2, isoform 3 and isoform 5)
Domain & Motif Annotations
Compositional Bias
376..400; Basic and acidic residues; 469..480; Pro residues; 483..492; Basic and acidic residues; 506..525; Basic and acidic residues
Domain (CC)
The N-terminal domain interacts with the C-terminal domain of LAYN. An interdomain interaction between its N-terminal and C-terminal domains inhibits its ability to bind LAYN. In the presence of acidic phospholipids, the interdomain interaction is inhibited and this enhances binding to LAYN (By similarity).
Domain (FT)
5..295; FERM
Region
310..330; Disordered; 376..407; Disordered; 462..526; Disordered
Clinical Relevance
Disease Involvement (3)
DeafnessDisease variantNon-syndromic deafness
Related Diseases (2)
Interaction Protein (2)
ENSG00000092820ENSG00000141522
Interaction Count
2
Interaction Dataset (2)
intact_biogrid_bioplexintact_biogrid
Supporting Publications13
| PMID | Title | Related sentences |
|---|---|---|
| 27605433 | Secreted primary human malignant mesothelioma exosome signature reflects oncogenic cargo. | No related sentences available |
| 27863537 | High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources. | No related sentences available |
| 27894104 | Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers. | No related sentences available |
| 28590090 | Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes. | No related sentences available |
| 28986585 | Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics. | No related sentences available |
| 29687628 | Proteomic Profiling Exosomes from Vascular Smooth Muscle Cell. | No related sentences available |
| 30646616 | Preferential Localization of MUC1 Glycoprotein in Exosomes Secreted by Non-Small Cell Lung Carcinoma Cells. | THBS1, ANXA6, HIST1H4A, COL18A1, MDK, SRGN, ENO1, TUBA4A, SLC3A2, GPI, MIF, MUC1, TALDO1, SLC7A5, ICAM1, HSP90AA1, G6PD, and LRP1 were found to be expressed in exosomes at more than 5-fold higher level as compared to total cellular membrane proteins. |
| 32089743 | Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. | No related sentences available |
| 32284825 | Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine. | No related sentences available |
| 33035814 | Knockout of PRDX6 induces mitochondrial dysfunction and cell cycle arrest at G2/M in HepG2 hepatocarcinoma cells. | No related sentences available |
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