Protein detail

SSR5

Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5)

Entry name SSR5	UniProt ID P35346	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Somatostatin receptor type 5 (SS-5-R) (SS5-R) (SS5R) (SST5)

Protein Function (2)

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

39..66; Helical; Name=1; 77..101; Helical; Name=2; 114..135; Helical; Name=3; 158..178; Helical; Name=4; 198..222; Helical; Name=5; 248..273; Helical; Name=6; 284..308; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000162009

Entrez Gene Symbol

SSTR5

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization4

Tissue Specificfallopian tubeCell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cellBlood Cell Specificplasmacytoid DC

Function & Pathway8

Protein Function (2)

FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component (2)

Molecular Function (3)

Biological Process (3)

KEGG (4)

Reactome (5)

Canonical Pathways

M83 Pid cdc42 reg pathway

Mediation Categories (3)

Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation

Relations & Evidence61

Enzyme-Mediated Modification (1)

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
SSTR5	GRK2	P25098	T	333	phosphorylation	PhosphoSite

Ligand-Receptor Signaling (55)

55 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
gpcr	receptor	Almen2009	No	Yes	No	Yes	No
rhodopsin	receptor	Almen2009	No	Yes	No	Yes	No
gpcr	receptor	UniProt_keyword	No	Yes	No	Yes	No
seven_transmembrane_7tm	receptor	HPMR	No	Yes	No	Yes	No
7tm_a	receptor	HPMR	No	Yes	No	Yes	No
somatostatin_oprl_npw_7tm_a	receptor	HPMR	No	Yes	No	Yes	No
rhodopsin	receptor	Surfaceome	No	Yes	No	Yes	No
gpcr	receptor	Surfaceome	No	Yes	No	Yes	No
class_a_rhodopsin	receptor	GPCRdb	No	Yes	No	Yes	No
class_a_rhodopsin_peptide	receptor	GPCRdb	No	Yes	No	Yes	No

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Regulatory Interaction Network (3)

3 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
SSR5	P35346	GNAO	P09471	Yes	Yes	No	SIGNOR	SIGNOR:31160049
SSR5	P35346	GNAI3	P08754	Yes	Yes	No	SIGNOR	SIGNOR:31160049
SSR5	P35346	GNAI1	P63096	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
PDZK1-PLCB3-SSTR5 complex	PDZK1 PLCB3 SSTR5	P35346 Q01970 Q5T2W1	0:0:0	CORUM	CORUM:7040	22528496

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains11

Sequences

Length

364

Mass

39,202

Sequence

MEPLFPASTPSWNASSPGAASGGGDNRTLVGPAPSAGARAVLVPVLYLLVCAAGLGGNTLVIYVVLRFAKMKTVTNIYILNLAVADVLYMLGLPFLATQNAASFWPFGPVLCRLVMTLDGVNQFTSVFCLTVMSVDRYLAVVHPLSSARWRRPRVAKLASAAAWVLSLCMSLPLLVFADVQEGGTCNASWPEPVGLWGAVFIIYTAVLGFFAPLLVICLCYLLIVVKVRAAGVRVGCVRRRSERKVTRMVLVVVLVFAGCWLPFFTVNIVNLAVALPQEPASAGLYFFVVILSYANSCANPVLYGFLSDNFRQSFQKVLCLRKGSGAKDADATEPRPDRIRQQQEATPPAHRAAANGLMQTSKL

3D Structural Models

Turn

144..150; 189..191; 279..281; 304..307

Helix

43..66; 74..90; 93..101; 108..142; 153..177; 181..183; 194..209; 211..234; 241..273; 283..303; 309..315

Beta Strand

71..73

3D Structure

Electron microscopy (5)

Domain & Motif Annotations

Compositional Bias

327..342; Basic and acidic residues

Region

1..20; Disordered; 327..364; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Related Diseases (3)

Alzheimer disease Cushing syndrome Stomach cancer

Biomarker

Terminated; Approved; Investigative

Drugs (13)

OCTREOTIDE ACETATE NULL VAPREOTIDE LANREOTIDE ACETATE VELDOREOTIDE PASIREOTIDE CHEMBL:CHEMBL452157 LUTETIUM DOTATATE LU-177 PASIREOTIDE DIASPARTATE LUTETIUM LU 177 DOTATATE ONZIGOLIDE PASIREOTIDE PAMOATE SOMATOSTATIN

Supporting Publications1

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available