Protein detail
ADA1B
Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor)
Entry name ADA1B | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 4 | Transmembrane count 7 | Protein classification |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information8
Protein Names
Alpha-1B adrenergic receptor (Alpha-1B adrenoreceptor) (Alpha-1B adrenoceptor)
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
46..70; Helical; Name=1; 84..105; Helical; Name=2; 116..141; Helical; Name=3; 162..184; Helical; Name=4; 202..224; Helical; Name=5; 296..319; Helical; Name=6; 327..351; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Supporting publications (n)
4
EVMP confidence score
0.50
Function & Pathway8
Protein Function (4)
- Cancer-related genes:Candidate cancer biomarkers
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (5)
Molecular Function (3)
Biological Process (3)
KEGG (8)
- hsa04020 Calcium signaling pathway
- KEGG:hsa04022 cGMP-PKG signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04081 Hormone signaling
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04261 Adrenergic signaling in cardiomyocytes
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04970 Salivary secretion
Reactome (7)
Canonical Pathways (2)
- M256 Pid tap63 pathway
- M17 Pid notch pathway
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence66
Enzyme-Mediated Modification (8)
8 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| ADRA1B | PRKCA | P17252 | S | 402 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9353340KEA:9353340ProtMapper:9353340 |
| ADRA1B | PRKCA | P17252 | S | 396 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9353340KEA:9353340ProtMapper:9353340 |
| ADRA1B | PRKCA | P17252 | S | 412 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9353340KEA:9353340ProtMapper:9353340 |
| ADRA1B | PRKCA | P17252 | S | 406 | phosphorylation | MIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9353340KEA:9353340ProtMapper:9353340 |
| ADRA1B | PRKCA | P17252 | S | 410 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEASIGNOR_ProtMapper | SIGNOR:9353340KEA:9353340ProtMapper:9353340 |
| ADRA1B | PRKCA | P17252 | S | 400 | phosphorylation | KEA | KEA:17570479 |
| ADRA1B | GRK2 | P25098 | S | 410 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:9353340 |
| ADRA1B | RPS6KA3 | P51812 | S | 400 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (48)
48 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
Regulatory Interaction Network (9)
9 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| ADA1B | P35368 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
| KPCA | P17252 | ADA1B | P35368 | Yes | Yes | Yes | WangPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperNetworKIN_KEA | SIGNOR:9353340KEA:9353340HPRD:9353340KEA:17570479ProtMapper:9353340 |
| ADA1B | P35368 | GNAS3 | O95467 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ADA1B | P35368 | ALEX | P84996 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ADA1B | P35368 | GNAS2 | P63092 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ADA1B | P35368 | GNAS1 | Q5JWF2 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ADA1B | P35368 | GNA11 | P29992 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:1334487HPRD:9481484 |
| ADA1B | P35368 | GNAL | P38405 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| ADA1B | P35368 | GNAQ | P50148 | Yes | Yes | No | HPRDWangSIGNOR | SIGNOR:31160049HPRD:9481484 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration | Mass spectrometryAntibody arrayMass spectrometry [QTOF]Small R sequencing (Illumi HiSeq 2000 (Solexa) | 1 | 37573658 |
Sequence, Structure & Domains7
Sequences
Length
520
Mass
56,836
Sequence
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
Domain & Motif Annotations
Motif
368..380; Nuclear localization signal
Region
394..432; Disordered; 479..520; Disordered
Protein Families (3)
- G-protein coupled receptor 1 family
- Adrenergic receptor subfamily
- ADRA1B sub-subfamily
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
Clinical Relevance3
Related Diseases (7)
Biomarker
Discontinued in Phase 2; Approved; Terminated
Drugs (70)
TERAZOSIN HYDROCHLORIDEEPINEPHRINE BITARTRATEVASOACTIVE INTESTINAL PEPTIDESERTINDOLEQUETIAPINE FUMARATELABETALOLNAPHAZOLINE HYDROCHLORIDEPRAZOSINPERICIAZINEMETHAMPHETAMINEALFUZOSINAJMALICINETAMSULOSIN HYDROCHLORIDELISDEXAMFETAMINE DIMESYLATER-SPONDIN-2R-SPONDIN-1MIDODRINEPHENDIMETRAZINEMEDETOMIDINETETRAHYDROZOLINE HYDROCHLORIDEMETHOTRIMEPRAZINER-SPONDIN-3DOPAMINESENREBOTASEOLANZAPINEMETHOXAMINEPHENOXYBENZAMINENOREPINEPHRINEDIPIVEFRIN HYDROCHLORIDEISOXSUPRINE HYDROCHLORIDETRAZODONEBETHANIDINETERAZOSINERGOTAMINE TARTRATEMOXISYLYTEXYLOMETAZOLINEPHENYLEPHRINER-SPONDIN-4EPHEDRINEMETHOXAMINE HYDROCHLORIDECARVEDILOLDEBRISOQUINISOPROTERENOLDOXAZOSIN MESYLATETRIMIPRAMINE MALEATERAUWOLFIA SERPENTINA (USP)EPHEDRINE HYDROCHLORIDEDAPIPRAZOLEPHENTOLAMINE MESYLATEBUCINDOLOL HYDROCHLORIDENULLEPINEPHRINELABETALOL HYDROCHLORIDENOREPINEPHRINE BITARTRATENEFAZODONEPROMAZINEDROXIDOPABUNAZOSINPHENOXYBENZAMINE HYDROCHLORIDEPROPIOMAZINEERGOLOID MESYLATES, USPMEPHENTERMINE SULFATEPHENYLEPHRINE BITARTRATEOXYMETAZOLINE HYDROCHLORIDETOLAZOLINE HYDROCHLORIDEPRAZOSIN HYDROCHLORIDEPHENYLEPHRINE HYDROCHLORIDEHYDROXYAMPHETAMINE HYDROBROMIDEMETARAMINOL BITARTRATEALFUZOSIN HYDROCHLORIDE
Supporting Publications4
| PMID | Title | Abstract |
|---|---|---|
| 38113368 | In-Depth Proteome Profiling of Small Extracellular Vesicles Isolated from Cancer Cell Lines and Patient Serum. | No abstract available |
| 39001700 | Optimized AF4 combined with density cushion ultracentrifugation enables profiling of high-purity human blood extracellular vesicles. | No abstract available |
| 39207047 | The trajectory of vesicular proteomic signatures from HBV-HCC by chitosan-magnetic bead-based separation and DIA-proteomic analysis. | No abstract available |
| 40189497 | Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis. | No abstract available |