Protein detail
PE2R4
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Protein symbol PE2R4 | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
20..43; Helical; Name=1; 56..79; Helical; Name=2; 97..115; Helical; Name=3; 136..160; Helical; Name=4; 185..211; Helical; Name=5; 268..295; Helical; Name=6; 313..332; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
43 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | No | Yes | No |
| receptor | receptor | HPMR | No | Yes | No | Yes | No |
| receptor | receptor | CellChatDB | No | Yes | No | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | No | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | No | Yes | No |
| gpcr | receptor | DGIdb | No | Yes | No | Yes | No |
| gpcr | receptor | Almen2009 | No | Yes | No | Yes | No |
| rhodopsin | receptor | Almen2009 | No | Yes | No | Yes | No |
| gpcr | receptor | UniProt_keyword | No | Yes | No | Yes | No |
| seven_transmembrane_7tm | receptor | HPMR | No | Yes | No | Yes | No |
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Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| PE2R4 | P35408 | GNAS3 | O95467 | Yes | Yes | No | HINTSIGNOR | SIGNOR:31160049HINT:33264604HINT:37478163 |
| PE2R4 | P35408 | ALEX | P84996 | Yes | Yes | No | HINTSIGNOR | SIGNOR:31160049HINT:33264604HINT:37478163 |
| PE2R4 | P35408 | GNAS2 | P63092 | Yes | Yes | No | HINTSIGNOR | SIGNOR:31160049HINT:33264604HINT:37478163 |
| PE2R4 | P35408 | GNAS1 | Q5JWF2 | Yes | Yes | No | HINTSIGNOR | SIGNOR:31160049HINT:33264604HINT:37478163 |
| PE2R4 | P35408 | GNAL | P38405 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
488
Mass
53,119
Sequence
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
3D Structural Models
Turn
113..115; 165..167; 179..181; 267..269; 306..308; 326..330; 335..337
Helix
23..44; 47..49; 53..81; 92..112; 116..122; 124..130; 135..151; 153..156; 182..217; 271..297; 312..317; 320..323
Beta Strand
82..84; 132..134; 161..163; 170..172
3D Structure
Electron microscopy (6); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
361..376; Polar residues; 437..449; Polar residues
Region
356..376; Disordered; 437..475; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Approved; Discontinued in Phase 3; Phase 4; Phase 1; Investigative; Phase 2; Phase 3