Protein detail

PE2R4

Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)

Entry name PE2R4	UniProt ID P35408	EVMP confidence score 0.25
Supporting publications (n) 2	Transmembrane count 7	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information8

Protein Names

Prostaglandin E2 receptor EP4 subtype (PGE receptor EP4 subtype) (PGE2 receptor EP4 subtype) (Prostanoid EP4 receptor)

Protein Function (3)

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

20..43; Helical; Name=1; 56..79; Helical; Name=2; 97..115; Helical; Name=3; 136..160; Helical; Name=4; 185..211; Helical; Name=5; 268..295; Helical; Name=6; 313..332; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000125384

Entrez Gene Symbol

PTGER2

Supporting publications (n)

EVMP confidence score

0.25

Function & Pathway7

Protein Function (3)

Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

GO:0005886 plasma membrane

Molecular Function

GO:0004957 prostaglandin E receptor activity

Biological Process (3)

KEGG (7)

Reactome (6)

Mediation Categories (3)

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence49

Ligand-Receptor Signaling (43)

43 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
prostaglandin	receptor	HGNC	No	Yes	No	Yes	No
receptor	receptor	HGNC	No	Yes	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Regulatory Interaction Network (5)

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PE2R4	P35408	GNAS3	O95467	Yes	Yes	No	HINTSIGNOR	SIGNOR:31160049 HINT:33264604 HINT:37478163
PE2R4	P35408	ALEX	P84996	Yes	Yes	No	HINTSIGNOR	SIGNOR:31160049 HINT:33264604 HINT:37478163
PE2R4	P35408	GNAS2	P63092	Yes	Yes	No	HINTSIGNOR	SIGNOR:31160049 HINT:33264604 HINT:37478163
PE2R4	P35408	GNAS1	Q5JWF2	Yes	Yes	No	HINTSIGNOR	SIGNOR:31160049 HINT:33264604 HINT:37478163
PE2R4	P35408	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
	Mass spectrometry	0

Sequence, Structure & Domains11

Sequences

Length

488

Mass

53,119

Sequence

MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI

3D Structural Models

Turn

113..115; 165..167; 179..181; 267..269; 306..308; 326..330; 335..337

Helix

23..44; 47..49; 53..81; 92..112; 116..122; 124..130; 135..151; 153..156; 182..217; 271..297; 312..317; 320..323

Beta Strand

82..84; 132..134; 161..163; 170..172

3D Structure

Electron microscopy (6); X-ray crystallography (2)

Domain & Motif Annotations

Compositional Bias

361..376; Polar residues; 437..449; Polar residues

Region

356..376; Disordered; 437..475; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance3

Related Diseases (14)

Abortion Arterial occlusive disease Coronary atherosclerosis Diabetic foot ulcer Endometriosis Glaucoma Immune system disease Low bone mass disorder Pemphigus Pulmonary hypertension Sexual dysfunction Solid tumour/cancer Transplant rejection Transplanted organ/tissue

Biomarker

Approved; Discontinued in Phase 3; Phase 4; Phase 1; Investigative; Phase 2; Phase 3

Drugs (16)

ALPROSTADIL DINOPROSTONE BUTAPROST NULL OMIDENEPAG ASPIRIN DINOPROST MYCOPHENOLATE MOFETIL OMIDENEPAG ISOPROPYL TAPRENEPAG ISOPROPYL TAPRENEPAG SIMENEPAG ISOPROPYL EVATANEPAG 16,16-DIMETHYL-PGE2 ILOPROST LAROPIPRANT

Supporting Publications2

PMID	Title	Abstract
37922300	Proteomic profiling of urinary extracellular vesicles differentiates breast cancer patients from healthy women.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available