Protein detail
APJ
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
Protein symbol APJ | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 7 | Protein classification G-protein coupled receptorsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Apelin receptor (Angiotensin receptor-like 1) (G-protein coupled receptor APJ) (G-protein coupled receptor HG11)
Protein Class
G-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
31..54; Helical; Name=1; 65..86; Helical; Name=2; 100..125; Helical; Name=3; 147..164; Helical; Name=4; 199..223; Helical; Name=5; 247..270; Helical; Name=6; 290..312; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
AGTRL1APJAPJRFLJ90771
Gene Description
Apelin receptor
Chromosome
11
Position
57233577-57237250
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
Reactome
Canonical Pathways
- M1718 Sig il4receptor in b lyphocytes
- M234 Pid il2 stat5 pathway
- M45 Pid cd40 pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
59 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | Cellinker | No | No | No | Yes | No |
| plasma_membrane | plasma_membrane | OmniPath | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | CSPA | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | HPMR | No | No | No | Yes | No |
| plasma_membrane_transmembrane | plasma_membrane_transmembrane | OmniPath | No | No | No | Yes | No |
| cell_surface | cell_surface | Surfaceome | No | No | No | Yes | No |
| cell_surface | cell_surface | connectomeDB2020 | No | No | No | Yes | No |
| cell_surface | cell_surface | OmniPath | No | No | No | Yes | No |
| receptor | receptor | talklr | No | Yes | No | Yes | No |
Regulatory Interaction Network
3 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| APJ | P35414 | GNA14 | O95837 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| APJ | P35414 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| APJ | P35414 | GNAI1 | P63096 | Yes | Yes | No | HINTSIGNOR | HINT:38428423SIGNOR:31160049HINT:35817871 |
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
380
Mass
42,660
Sequence
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
3D Structural Models
Turn
21..23; 91..93; 134..136; 174..176; 186..188; 229..231; 276..278; 326..329
Helix
13..16; 25..28; 30..55; 58..60; 65..79; 82..90; 98..131; 137..140; 142..160; 162..167; 191..193; 194..209; 211..228; 245..275; 281..312; 314..325
Beta Strand
9..12; 18..20; 168..171; 180..183; 234..236
3D Structure
Electron microscopy (17); NMR spectroscopy (4); X-ray crystallography (3)
Domain & Motif Annotations
Compositional Bias
342..351; Low complexity; 371..380; Polar residues
Domain (CC)
The hydrogen bond between Asn-46 and Asp-75 is crucial for beta-arrestin signaling induced by APLN/apelin-13..
Region
342..380; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Phase 1
Drug Targets
Clinical trial target
Antibody