Protein detail
TSP2
Thrombospondin-2
Entry name TSP2 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Thrombospondin-2
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted secreted proteins
Protein Function
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Ensembl
Entrez Gene Symbol
Gene Synonym
TSP2
Gene Description
Thrombospondin 2
Chromosome
6
Position
169215780-169254050
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Cell SpecificMesothelial cellsBlood Cell Specificneutrophil
Function & Pathway
Protein Function
- Disease related genes
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Human disease related genes:Musculoskeletal diseases:Skeletal diseases
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-3906995 diseases associated with o glycosylation of proteins
- R-hsa-3781865 diseases of glycosylation
- R-hsa-5668914 diseases of metabolism
- R-hsa-5173214 o glycosylation of tsr domain containing proteins
- R-hsa-5173105 o linked glycosylation
- R-hsa-597592 post translational protein modification
- R-hsa-186797 signaling by pdgf
- R-hsa-9006934 signaling by receptor tyrosine kinases
Mediation Categories
Clinical-translation mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
26 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | HPA_secretome | No | No | Yes | No | No |
| secreted | secreted | connectomeDB2020 | No | No | Yes | No | No |
| secreted | secreted | Baccin2019 | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ecm | ecm | CellChatDB | Yes | No | Yes | No | No |
| ecm | ecm | Cellinker | Yes | No | Yes | No | No |
| glycoprotein | ecm | Matrisome | Yes | No | Yes | No | No |
| ligand | ligand | talklr | Yes | No | Yes | No | No |
| ligand | ligand | connectomeDB2020 | Yes | No | Yes | No | No |
| ligand | ligand | iTALK | Yes | No | Yes | No | No |
Regulatory Interaction Network
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| TSP2 | P35442 | CD47 | Q08722 | Yes | Yes | No | CellChatDBFantom5_LRdbCellTalkDBHPMR_LRdbiTALKHPMR_CellinkertalklrRamilowski2015SIGNORconnectomeDB2020UniProt_LRdbCellinkerWangLRdbHPMR_talklr | Cellinker:8550562LRdb:8550562connectomeDB2020:8550562CellTalkDB:8550562SIGNOR:8550562 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry | 1 | 37563857 |
Sequence, Structure & Domains
Sequences
Length
1,172
Mass
129,991
Sequence
MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI
3D Structural Models
Turn
593..596; 651..655; 706..710; 738..740; 751..753; 755..758; 810..812; 856..858; 894..896; 911..914; 1089..1091; 1118..1120
Helix
552..555; 637..640; 774..776; 797..799; 833..835; 871..873; 907..909; 930..932; 943..945; 983..985; 1076..1083
Beta Strand
564..566; 572..574; 585..587; 605..607; 610..612; 614..619; 626..628; 632..636; 646..648; 663..667; 673..680; 684..693; 697..700; 712..714; 734..736; 746..749; 767..772; 793..795; 805..808; 829..831; 851..854; 866..869; 890..892; 903..905; 926..928; 939..941; 960..968; 971..973; 979..982; 987..990; 995..1016; 1024..1033; 1036..1045; 1053..1055; 1061..1069; 1084..1086; 1092..1097; 1110..1116; 1122..1129; 1132..1136; 1139..1141; 1148..1156; 1159..1169
3D Structure
X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
847..866; Acidic residues; 870..884; Polar residues; 896..905; Acidic residues
Repeat
693..728; TSP type-3 1; 729..764; TSP type-3 2; 765..787; TSP type-3 3; 788..823; TSP type-3 4; 824..846; TSP type-3 5; 847..884; TSP type-3 6; 885..920; TSP type-3 7; 921..956; TSP type-3 8
Motif
928..930; Cell attachment site
Domain (FT)
19..215; Laminin G-like; 318..375; VWFC; 381..431; TSP type-1 1; 437..492; TSP type-1 2; 494..549; TSP type-1 3; 549..589; EGF-like 1; 648..692; EGF-like 2; 960..1172; TSP C-terminal
Region
19..232; Heparin-binding; 843..931; Disordered
Protein Families
Thrombospondin family
Sequence Similarities
Belongs to the thrombospondin family.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantEhlers-Danlos syndrome