Protein detail

SCN1A

Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

Entry name SCN1A	UniProt ID P35498	EVMP score 0.50
Frequency 1	Transmembrane count 24	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Voltage-gated ion channels:Voltage-Gated Sodium Channels
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Transmembrane

129..146; Helical; Name=S1 of repeat I; 153..177; Helical; Name=S2 of repeat I; 189..205; Helical; Name=S3 of repeat I; 214..235; Helical; Name=S4 of repeat I; 246..269; Helical; Name=S5 of repeat I; 398..423; Helical; Name=S6 of repeat I; 769..787; Helical; Name=S1 of repeat II; 798..820; Helical; Name=S2 of repeat II; 831..849; Helical; Name=S3 of repeat II; 855..874; Helical; Name=S4 of repeat II; 892..912; Helical; Name=S5 of repeat II; 966..992; Helical; Name=S6 of repeat II; 1219..1237; Helical; Name=S1 of repeat III; 1251..1276; Helical; Name=S2 of repeat III; 1279..1304; Helical; Name=S3 of repeat III; 1314..1332; Helical; Name=S4 of repeat III; 1346..1369; Helical; Name=S5 of repeat III; 1458..1483; Helical; Name=S6 of repeat III; 1542..1560; Helical; Name=S1 of repeat IV; 1572..1593; Helical; Name=S2 of repeat IV; 1602..1623; Helical; Name=S3 of repeat IV; 1637..1655; Helical; Name=S4 of repeat IV; 1666..1688; Helical; Name=S5 of repeat IV; 1760..1788; Helical; Name=S6 of repeat IV

Transmembrane Count

Ensembl

ENSG00000144285

Entrez Gene Symbol

SCN1A

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificEarly spermatidsSingle-Nuclei Brain Specifichippocampal dentate gyrus

Function & Pathway

Protein Function

Human disease related genes:Nervous system diseases:Other nervous and sensory system diseases
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Epilepsy
Voltage-gated ion channels:Voltage-Gated Sodium Channels
Transporters:Transporter channels and pores
Disease related genes
FDA approved drug targets:Small molecule drugs

Cellular Component

Molecular Function

Biological Process

KEGG

hsa04728 Dopaminergic synapse

Reactome

Canonical Pathways

M277 Pid integrin a4b1 pathway
M159 Pid amb2 neutrophils pathway
M18 Pid integrin1 pathway

Mediation Categories

Fusion and delivery mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

33 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	No	No
transmembrane	transmembrane	TopDB	No	No	No	No	No
transmembrane	transmembrane	LOCATE	No	No	No	No	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	No	No
transmembrane	transmembrane	OmniPath	No	No	No	No	No
peripheral	peripheral	UniProt_topology	No	No	No	No	No
peripheral	peripheral	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
cell_surface	cell_surface	Surfaceome	No	No	No	No	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FGF12	P61328	SCN1A	P35498	Yes	No	Yes	DIPSIGNOR	SIGNOR:20679355 DIP:22705208
FGF13	Q92913	SCN1A	P35498	Yes	No	Yes	SIGNOR	SIGNOR:20679355
FGF14	Q92915	SCN1A	P35498	Yes	No	Yes	SIGNOR	SIGNOR:20679355
FGF11	Q92914	SCN1A	P35498	Yes	No	Yes	SIGNOR	SIGNOR:20679355
NED4L	Q96PU5	SCN1A	P35498	Yes	No	Yes	SIGNOR	SIGNOR:23778145

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	CHD1 CPSF6 CSNK2A1 H2AX H2BC21 H3-3A H3C11 H4C4 SCN1A SMARCA5 SSRP1 SUPT16H TOP2A	O14646 O60264 P11388 P16104 P35498 P62805 P68400 P68431 P84243 Q08945 Q16630 Q16778 Q9Y5B9	1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC3752

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	FACSMass spectrometry	1	38902710

Sequence, Structure & Domains

Sequences

Length

2,009

Mass

228,972

Sequence

MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLEEHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMIEQLKKQQEAAQQAATATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIASDCQLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEIKPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPEACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCINTTTGDRFDIEDVNNHTDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK

Alternative Products

Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P35498-1; Sequence=Displayed; Name=2; IsoId=P35498-2; Sequence=VSP_001031; Name=3; IsoId=P35498-3; Sequence=VSP_045399

Alternative Sequence

654..681; Missing (in isoform 3); 671..681; Missing (in isoform 2)

3D Structural Models

Turn

269..271; 359..362; 763..766; 819..821; 886..890; 1234..1237; 1327..1329; 1379..1381; 1387..1389; 1470..1472; 1622..1627; 1692..1694; 1722..1725

Helix

117..125; 128..145; 152..176; 189..204; 215..225; 226..229; 234..245; 248..268; 272..274; 369..379; 384..395; 397..399; 400..438; 750..762; 770..786; 794..818; 832..847; 856..871; 874..885; 891..911; 915..918; 920..922; 937..949; 954..963; 965..994; 1204..1215; 1218..1233; 1240..1244; 1249..1280; 1283..1304; 1312..1315; 1316..1326; 1331..1341; 1344..1368; 1393..1401; 1418..1430; 1434..1442; 1457..1459; 1460..1469; 1473..1493; 1504..1514; 1530..1539; 1541..1559; 1567..1594; 1603..1620; 1632..1638; 1639..1642; 1643..1646; 1647..1651; 1656..1691; 1710..1721; 1726..1733; 1759..1792

Beta Strand

205..207; 315..318; 322..324; 365..367; 925..927; 1246..1248; 1369..1372; 1375..1378; 1406..1409; 1412..1417; 1703..1709; 1748..1751

3D Structure

Electron microscopy (1)

Domain & Motif Annotations

Compositional Bias

28..48; Basic and acidic residues; 456..466; Low complexity; 479..492; Low complexity; 495..506; Basic residues; 520..529; Basic and acidic residues; 593..607; Basic and acidic residues; 1988..2009; Basic and acidic residues

Repeat

110..454; I; 750..1022; II; 1200..1514; III; 1523..1821; IV

Domain (CC)

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1, S2, S3, S5, S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.; DOMAIN: The S3b-S4 and S1-S2 loops of repeat IV are targeted by H.maculata toxins Hm1a and Hm1b, leading to inhibit fast inactivation of Nav1.1/SCN1A. Selectivity for H.maculata toxins Hm1a and Hm1b depends on S1-S2 loops of repeat IV.

Domain (FT)

1915..1944; IQ

Region

28..60; Disordered; 455..529; Disordered; 584..627; Disordered; 1129..1163; Disordered; 1561..1571; S1-S2 loop of repeat IV; 1619..1636; S3b-S4 loop of repeat IV; 1986..2009; Disordered

Protein Families

Sodium channel (TC 1.A.1.10) family
Nav1.1/SCN1A subfamily

Sequence Similarities

Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.1/SCN1A subfamily.

Clinical Relevance

Drugs