Protein detail

MYH9

Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)

Entry name
MYH9
UniProt ID
P35579
EVMP confidence score
0.88
Supporting publications (n)
52
Transmembrane count
Protein classification
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information11
Protein Names
Myosin-9 (Cellular myosin heavy chain, type A) (Myosin heavy chain 9) (Myosin heavy chain, non-muscle IIa) (Non-muscle myosin heavy chain A) (NMMHC-A) (Non-muscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA)
Protein Class (5)
Cancer-related genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function (5)
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Ear disease
Ensembl
ENSG00000100345
Entrez Gene Symbol
MYH9
Gene Synonym (6)
DFNA17EPSTSFTNSMHANMHC-II-ANMMHCA
Gene Description
Myosin heavy chain 9
Chromosome
22
Position
36281280-36388010
Supporting publications (n)
52
EVMP confidence score
0.88
Fluorescence & Localization1
MYH9 fluorescence
Function & Pathway8
Protein Function (5)
  • Cancer-related genes:Mutational cancer driver genes
  • Human disease related genes:Cardiovascular diseases:Hematologic diseases
  • Predicted intracellular proteins
  • Disease related genes
  • Human disease related genes:Nervous system diseases:Ear disease
Cellular Component (28)
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Molecular Function (15)
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Biological Process (3)
KEGG (8)
Reactome (27)
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Canonical Pathways
M277 Pid integrin a4b1 pathway
Mediation Categories (6)
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence43

Enzyme-Mediated Modification (14)

14 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
MYH9PRKCAP17252S1,916phosphorylationBEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapperphosphoELM:9545325ProtMapper:15212693KEA:9545325KEA:91113708KEA:1899200phosphoELM:1899200
MYH9PRKCAP17252T638phosphorylationPhosphoNetworks
MYH9PRKCAP17252S1,915phosphorylationKEAKEA:17570479KEA:9545325
MYH9TRPM7Q96QT4T1,800phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapperKEA:18675813phosphoELM:18675813phosphoELM:18394644KEA:18394644
MYH9TRPM7Q96QT4S1,803phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapperphosphoELM:18394644KEA:18394644
MYH9TRPM7Q96QT4S1,808phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPProtMapperKEAphosphoELMPhosphoSitePhosphoSite_ProtMapperphosphoELM:18394644KEA:18394644
MYH9CSNK2A1P68400S1,943phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperSIGNOR:18971378ProtMapper:21316371ProtMapper:18971378SIGNOR:22123909ProtMapper:17567956ProtMapper:22123909SIGNOR:21316371SIGNOR:17567956
MYH9CSNK2A1P68400S1,916phosphorylationPhosphoSitePhosphoSite_ProtMapperProtMapper
MYH9PRKCBP05771S1,916phosphorylationMIMPPhosphoSitephosphoELM_MIMPPhosphoSite_MIMP
MYH9SRCP12931Y158phosphorylationPhosphoSitePhosphoSite_ProtMapperProtMapper
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Ligand-Receptor Signaling (11)

11 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
plasma_membraneplasma_membraneOmniPathNoNoNoNoNo
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Regulatory Interaction Network (8)

8 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
CSK21P68400MYH9P35579YesYesNophosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapperPhosphoSite:19826041PhosphoSite:22123909SIGNOR:18971378ProtMapper:21316371ProtMapper:18971378PhosphoSite:18971378PhosphoSite:30087119SIGNOR:22123909PhosphoSite:24462114ProtMapper:17567956ProtMapper:22123909SIGNOR:21316371PhosphoSite:30267961SIGNOR:17567956
SPC25Q9HBM1MYH9P35579YesYesNoSIGNORSIGNOR:39488790
RIOK1Q9BRS2MYH9P35579YesYesNoSIGNORSIGNOR:39488790
RHG07Q96QB1MYH9P35579YesNoYesSIGNORSIGNOR:26977077
MYH9P35579COMPLEX:O15514_P0CAP2_P19387_P19388_P24928_P30876_P36954_P52434_P52435_P53803_P61218_P62487_P62875_Q6EEV4_Q9GZM3_Q9H1A7YesYesNoSIGNORSIGNOR:32685004
S10A4P26447MYH9P35579YesNoYesSIGNORHPRDHINTBioGRIDIntActDIPDIP:22483112HINT:20421509IntAct:20421509IntAct:22483112BioGRID:37509135HINT:22460785SIGNOR:16707441DIP:20421509HPRD:9405067IntAct:31837246HPRD:15289939IntAct:22460785HINT:33961781HINT:22483112HINT:24830809
KPCAP17252MYH9P35579YesNoNoBEL-Large-Corpus_ProtMapperPhosphoNetworksphosphoELM_MIMPAdhesomeMIMPPhosphoSite_MIMPPhosphoSite_ProtMapperiPTMnetProtMapperPhosphoSite_KEAKinexus_KEAKEAphosphoELM_KEAphosphoELMPhosphoSiteNetworKIN_KEAphosphoELM:9545325PhosphoSite:25544611PhosphoSite:17567956ProtMapper:15212693KEA:9545325PhosphoSite:9545325KEA:91113708PhosphoSite:1899200Adhesome:9545325PhosphoSite:29208598Adhesome:91113708KEA:1899200KEA:17570479phosphoELM:1899200Adhesome:1899200PhosphoSite:21316371
SRCP12931MYH9P35579YesNoNoiPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapperPhosphoSite:25635050

Protein Complex Composition (9)

9 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
ACO2ACTBACTN2CKMCLNS1ACSGCN1H1-5HSPB6MYH2MYH9TNNI3TNNT2TPM1ZFP36O14558O75390P06732P09493P16401P19429P26651P35579P35609P45379P54105P60709Q92616Q99798Q9UKX21:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC6448
ACTRT1MYH10MYH9MYL12BMYL6MYO18APLECO14950O95411P35579P35580P60660Q15149Q8TDG20:0:0:0:0:0:0hu.MAP2
BECN1MYH10MYH9MYL12BMYL6USP45O14950P35579P35580P60660Q14457Q70EL21:1:1:1:1:1NetworkBlastCompleatCompleat:HC8563
ACTRT1MYH10MYH9MYL12BMYL6MYO18APLECO14950P35579P35580P60660Q15149Q8TDG2Q926140:0:0:0:0:0:0hu.MAP2
ACO2ACTBACTN2CKMCSGCN1H1-5MYH9NDUFB10NTPCRSLC25A3TNNI3TNNT2TPM1ZFP36O75390O96000P06732P09493P16401P19429P26651P35579P35609P45379P60709Q00325Q92616Q99798Q9BSD71:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC7939
ACO2ACTBACTN2CKMCSGCN1H1-5MAPRE3MYH2MYH9TNNC1TNNI3TNNT2TPM1ZFP36O75390P06732P09493P16401P19429P26651P35579P35609P45379P60709P63316Q92616Q99798Q9UKX2Q9UPY81:1:1:1:1:1:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC7155
ACTBCALM3CORO1AMCM5MYH9MYL6MYO19PWP1UBCUNC45AP0CG48P0DP25P31146P33992P35579P60660P60709Q13610Q96H55Q9H3U11:1:1:1:1:1:1:1:1:1NetworkBlastCompleatCompleat:HC8287
MYH9S100A4P26447P355792:1PDBPDB:4etoPDB:4cfqPDB:3zwhPDB:2lnkPDB:4cfr
MYH10MYH9P35579P355800:0hu.MAP2

Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry137886648
Sequence, Structure & Domains15

Sequences

Length
1,960
Mass
226,532
Sequence
MAQQAADKYLYVDKNFINNPLAQADWAAKKLVWVPSDKSGFEPASLKEEVGEEAIVELVENGKKVKVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKNLPIYSEEIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASSHKSKKDQGELERQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGAGEHLKTDLLLEPYNKYRFLSNGHVTIPGQQDKDMFQETMEAMRIMGIPEEEQMGLLRVISGVLQLGNIVFKKERNTDQASMPDNTAAQKVSHLLGINVTDFTRGILTPRIKVGRDYVQKAQTKEQADFAIEALAKATYERMFRWLVLRINKALDKTKRQGASFIGILDIAGFEIFDLNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLIEKPAGPPGILALLDEECWFPKATDKSFVEKVMQEQGTHPKFQKPKQLKDKADFCIIHYAGKVDYKADEWLMKNMDPLNDNIATLLHQSSDKFVSELWKDVDRIIGLDQVAGMSETALPGAFKTRKGMFRTVGQLYKEQLAKLMATLRNTNPNFVRCIIPNHEKKAGKLDPHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQACVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIIGFQACCRGYLARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEEVDGKADGAEAKPAE
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P35579-1; Sequence=Displayed; Name=2; IsoId=P35579-2; Sequence=VSP_035409, VSP_035410
Alternative Sequence
1..136; Missing (in isoform 2); 980..1421; Missing (in isoform 2)

3D Structural Models

Helix
1899..1903; 1904..1921
Beta Strand
1895..1897; 1922..1925
3D Structure
NMR spectroscopy (1); X-ray crystallography (4)

Domain & Motif Annotations

Compositional Bias
1035..1055; Basic and acidic residues; 1122..1137; Basic and acidic residues; 1948..1960; Basic and acidic residues
Coiled Coil
837..1926
Domain (CC)
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Domain (FT)
27..77; Myosin N-terminal SH3-like; 81..776; Myosin motor; 779..808; IQ
Region
2..838; Mediates interaction with LIMCH1; 654..676; Actin-binding; 1035..1057; Disordered; 1118..1137; Disordered; 1877..1960; Disordered
Protein Families (2)
  • TRAFAC class myosin-kinesin ATPase superfamily
  • Myosin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
Clinical Relevance5
Disease Involvement (6)
Alport syndromeCancer-related genesCataractDeafnessDisease variantNon-syndromic deafness
Antibody (3)
HPA001644CAB015386HPA064783
Interaction Protein (10)
ENSG00000077549ENSG00000092841ENSG00000101335ENSG00000101608ENSG00000118680ENSG00000133895ENSG00000144381ENSG00000177885ENSG00000196154ENSG00000196465
Interaction Count
10
Interaction Dataset (4)
biogrid_opencellintact_biogrid_opencellbiogrid_opencell_bioplexintact_biogrid
Supporting Publications50
PMIDTitleAbstract
20031610Proteomics, metabolomics, and immunomics on microparticles derived from human atherosclerotic plaques.No abstract available
21630462Proteomic analysis of microvesicles derived from human colorectal cancer ascites.No abstract available
22740476Restoration of full-length APC protein in SW480 colon cancer cells induces exosome-mediated secretion of DKK-4.No abstract available
27234505Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury.No abstract available
27894104Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers.No abstract available
28590090Motile hepatocellular carcinoma cells preferentially secret sugar metabolism regulatory proteins via exosomes.No abstract available
28986585Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics.No abstract available
29045505Surfaceome profiling enables isolation of cancer-specific exosomal cargo in liquid biopsies from pancreatic cancer patients.Proteomic analysis of the exosome 'surfaceome' revealed multiple PDAC-specific biomarker candidates: CLDN4, EPCAM, CD151, LGALS3BP, HIST2H2BE, and HIST2H2BF. Droplet digital PCR was used on 74 patients (136 total exosome samples) to determine baseline KRAS mutation call rates while patients were on therapy. KRAS mutations in total exosomes were detected in 44.1% of patients undergoing active therapy compared with 73.0% following exosome capture using the selected biomarkers.
29148239Metabolic Signature of Microvesicles from Umbilical Cord Mesenchymal Stem Cells of Preterm and Term Infants.No abstract available
29436780Autosomal Tubulointerstitial Kidney Disease-MUC1 Type: Differential Proteomics Suggests that Mutated MUC1 (insC) Affects Vesicular Transport in Renal Epithelial Cells.No abstract available
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