Protein detail

BASI

Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)

Entry name BASI	UniProt ID P35613	EVMP confidence score 0.38
Supporting publications (n) 7	Transmembrane count 1	Protein classification Blood group antigen proteinsCD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

Protein Class (5)

Blood group antigen proteinsCD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters

Protein Function (4)

Predicted intracellular proteins
Blood group antigen proteins
CD markers
Transporters:Accessory Factors Involved in Transport

Transmembrane

324..344; Helical

Transmembrane Count

Ensembl

ENSG00000172270

Entrez Gene Symbol

BSG

Gene Synonym (4)

CD147EMMPRINEMPRINOK

Gene Description

Basigin (Ok blood group)

Chromosome

Position

571277-583494

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization2

Tissue Specificadipose tissueCell SpecificAdipocytes

Function & Pathway7

Protein Function (4)

Predicted intracellular proteins
Blood group antigen proteins
CD markers
Transporters:Accessory Factors Involved in Transport

Cellular Component (15)

Page 1 of 2

Molecular Function (5)

Biological Process (3)

KEGG

hsa04148 Efferocytosis

Reactome (14)

Page 1 of 2

Mediation Categories (5)

Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation

Relations & Evidence54

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
BSG	NEK6	Q9HC98	S	252	phosphorylation	PhosphoSite
BSG	FYN	P06241	Y	140	phosphorylation	PhosphoSite
BSG	FYN	P06241	Y	183	phosphorylation	PhosphoSite
BSG	EGF	P01133	S	246	phosphorylation	BEL-Large-Corpus_ProtMapperProtMapper	ProtMapper:17081983

Ligand-Receptor Signaling (34)

34 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	OmniPath	No	Yes	No	Yes	No
extracellular	extracellular	OmniPath	No	No	No	Yes	No
intracellular	intracellular	LOCATE	No	No	No	Yes	No
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	connectomeDB2020	Yes	No	No	Yes	No
cell_surface_ligand	cell_surface_ligand	CellPhoneDB	Yes	No	No	Yes	No

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Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	BASI	P35613	Yes	Yes	No	PhosphoSite_norefPhosphoSiteSIGNOR	PhosphoSite:32291412 SIGNOR:32291412
	COMPLEX:P62877_P63208_Q13616	BASI	P35613	Yes	No	Yes	SIGNOR	SIGNOR:28117675
FBX22	Q8NEZ5	BASI	P35613	Yes	No	Yes	SIGNOR	SIGNOR:28117675
NEK6	Q9HC98	BASI	P35613	Yes	No	Yes	PhosphoSiteSIGNOR	PhosphoSite:31016558 SIGNOR:31016558 PhosphoSite:28684116

Protein Complex Composition (11)

11 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	BSG XKR8	P35613 Q9H6D3	1:1	PDB	PDB:7dcePDB:8xej

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential Ultracentrifugation	Western BlottingMass SpectrometryElisaFlow Cytometry	1	38014595

Sequence, Structure & Domains11

Sequences

Length

385

Mass

42,200

Sequence

MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS

Alternative Products

Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long, Basigin-1; IsoId=P35613-1; Sequence=Displayed; Name=2; Synonyms=Short, Basigin-2; IsoId=P35613-2; Sequence=VSP_011501; Name=3; Synonyms=Basigin-3; IsoId=P35613-3; Sequence=VSP_043225; Name=4; Synonyms=Basigin-4; IsoId=P35613-4; Sequence=VSP_043226, VSP_043227

Alternative Sequence

1..209; Missing (in isoform 3); 1..11; MAAALFVLLGF -> MKQSDASPQER (in isoform 4); 12..191; Missing (in isoform 4); 24..139; Missing (in isoform 2)

3D Structural Models

Turn

292..294; 323..325

Helix

74..77; 100..102; 194..196; 270..272; 326..353

Beta Strand

24..27; 32..35; 40..47; 53..62; 79..95; 104..111; 116..118; 128..137; 142..149; 152..159; 166..173; 176..181; 186..192; 199..207; 210..217; 224..226; 228..232; 234..236; 238..243; 250..258; 260..262; 263..265; 274..278; 280..287; 297..305; 308..318

3D Structure

Electron microscopy (7); NMR spectroscopy (1); X-ray crystallography (9)

Domain & Motif Annotations

Domain (FT)

37..120; Ig-like; 138..219; Ig-like C2-type; 221..315; Ig-like V-type

Region

353..385; Disordered; P35613-2:195..199; Essential for interaction with KDR/VEGFR2

Clinical Relevance8

Related Diseases (3)

Graft-versus-host disease Liver cancer COVID-19

Biomarker

Phase 2/3; Phase 2; Phase 1/2

Drug Targets

Clinical trial target

Drugs (9)

GAVILIMOMAB NULL SINIGRIN METHIMAZOLE PROPYLTHIOURACIL ZIRALIMUMAB N-PHENYLTHIOUREA PROBENECID GOITRIN

Antibody (3)

CAB002427 HPA036048 HPA074870

Interaction Protein (4)

ENSG00000070961ENSG00000127022ENSG00000155380ENSG00000196262

Interaction Count

Interaction Dataset (2)

biogrid_opencellintact_biogrid

Supporting Publications7

PMID	Title	Abstract
31805958	Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive impairment.	No abstract available
33309826	Proteomic analysis of extracellular vesicles and conditioned medium from human adipose-derived stem/stromal cells and dermal fibroblasts.	No abstract available
34576246	Burn Injury Induces Proinflammatory Plasma Extracellular Vesicles That Associate with Length of Hospital Stay in Women: CRP and SAA1 as Potential Prognostic Indicators.	No abstract available
36146834	Human Cytomegalovirus Modifies Placental Small Extracellular Vesicle Composition to Enhance Infection of Fetal Neural Cells In Vitro.	No abstract available
38207106	Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity.	No abstract available
40189497	Small extracellular vesicle-based one-step high-throughput microfluidic platform for epithelial ovarian cancer diagnosis.	No abstract available
40730843	Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury.	No abstract available