Protein detail
BASI
Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
Entry name BASI | UniProt ID | EVMP score 0.38 |
Frequency 7 | Transmembrane count 1 | Protein classification Blood group antigen proteinsCD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Basigin (5F7) (Collagenase stimulatory factor) (Extracellular matrix metalloproteinase inducer) (EMMPRIN) (Hepatoma-associated antigen) (HAb18G) (Leukocyte activation antigen M6) (OK blood group antigen) (Tumor cell-derived collagenase stimulatory factor) (TCSF) (CD antigen CD147)
Protein Class
Blood group antigen proteinsCD markersPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Blood group antigen proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Transmembrane
324..344; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD147EMMPRINEMPRINOK
Gene Description
Basigin (Ok blood group)
Chromosome
19
Position
571277-583494
Frequency
7
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificadipose tissueCell SpecificAdipocytes
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Blood group antigen proteins
- CD markers
- Transporters:Accessory Factors Involved in Transport
Cellular Component
- GO:0000139 Golgi membrane
- GO:0001750 photoreceptor outer segment
- GO:0001917 photoreceptor inner segment
- GO:0002080 acrosomal membrane
- GO:0005739 mitochondrion
- GO:0005768 endosome
- GO:0005789 endoplasmic reticulum membrane
- GO:0005886 plasma membrane
- GO:0005925 focal adhesion
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0042383 sarcolemma
- GO:0042470 melanosome
- GO:0043231 intracellular membrane-bounded organelle
- GO:0070062 extracellular exosome
Molecular Function
Biological Process
Reactome
- R-hsa-9749641 aspirin adme
- R-hsa-210991 basigin interactions
- R-hsa-202733 cell surface interactions at the vascular wall
- R-hsa-1474228 degradation of the extracellular matrix
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-9748784 drug adme
- R-hsa-1474244 extracellular matrix organization
- R-hsa-109582 hemostasis
- R-hsa-216083 integrin cell surface interactions
- R-hsa-433692 proton coupled monocarboxylate transport
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9955298 slc mediated transport of organic anions
- R-hsa-5619102 slc transporter disorders
- R-hsa-382551 transport of small molecules
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| BSG | NEK6 | Q9HC98 | S | 252 | phosphorylation | PhosphoSite | |
| BSG | FYN | P06241 | Y | 140 | phosphorylation | PhosphoSite | |
| BSG | FYN | P06241 | Y | 183 | phosphorylation | PhosphoSite | |
| BSG | EGF | P01133 | S | 246 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
Ligand-Receptor Signaling
34 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| basigin | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FYN | P06241 | BASI | P35613 | Yes | Yes | No | PhosphoSite_norefPhosphoSiteSIGNOR | PhosphoSite:32291412SIGNOR:32291412 |
| COMPLEX:P62877_P63208_Q13616 | BASI | P35613 | Yes | No | Yes | SIGNOR | SIGNOR:28117675 | |
| FBX22 | Q8NEZ5 | BASI | P35613 | Yes | No | Yes | SIGNOR | SIGNOR:28117675 |
| NEK6 | Q9HC98 | BASI | P35613 | Yes | No | Yes | PhosphoSiteSIGNOR | PhosphoSite:31016558SIGNOR:31016558PhosphoSite:28684116 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Western BlottingMass SpectrometryElisaFlow Cytometry | 1 | 38014595 |
Sequence, Structure & Domains
Sequences
Length
385
Mass
42,200
Sequence
MAAALFVLLGFALLGTHGASGAAGFVQAPLSQQRWVGGSVELHCEAVGSPVPEIQWWFEGQGPNDTCSQLWDGARLDRVHIHATYHQHAASTISIDTLVEEDTGTYECRASNDPDRNHLTRAPRVKWVRAQAVVLVLEPGTVFTTVEDLGSKILLTCSLNDSATEVTGHRWLKGGVVLKEDALPGQKTEFKVDSDDQWGEYSCVFLPEPMGTANIQLHGPPRVKAVKSSEHINEGETAMLVCKSESVPPVTDWAWYKITDSEDKALMNGSESRFFVSSSQGRSELHIENLNMEADPGQYRCNGTSSKGSDQAIITLRVRSHLAALWPFLGIVAEVLVLVTIIFIYEKRRKPEDVLDDDDAGSAPLKSSGQHQNDKGKNVRQRNSS
Alternative Products
Event=Alternative promoter usage, Alternative splicing; Named isoforms=4; Name=1; Synonyms=Long, Basigin-1; IsoId=P35613-1; Sequence=Displayed; Name=2; Synonyms=Short, Basigin-2; IsoId=P35613-2; Sequence=VSP_011501; Name=3; Synonyms=Basigin-3; IsoId=P35613-3; Sequence=VSP_043225; Name=4; Synonyms=Basigin-4; IsoId=P35613-4; Sequence=VSP_043226, VSP_043227
Alternative Sequence
1..209; Missing (in isoform 3); 1..11; MAAALFVLLGF -> MKQSDASPQER (in isoform 4); 12..191; Missing (in isoform 4); 24..139; Missing (in isoform 2)
3D Structural Models
Turn
292..294; 323..325
Helix
74..77; 100..102; 194..196; 270..272; 326..353
Beta Strand
24..27; 32..35; 40..47; 53..62; 79..95; 104..111; 116..118; 128..137; 142..149; 152..159; 166..173; 176..181; 186..192; 199..207; 210..217; 224..226; 228..232; 234..236; 238..243; 250..258; 260..262; 263..265; 274..278; 280..287; 297..305; 308..318
3D Structure
Electron microscopy (7); NMR spectroscopy (1); X-ray crystallography (9)
Domain & Motif Annotations
Domain (FT)
37..120; Ig-like; 138..219; Ig-like C2-type; 221..315; Ig-like V-type
Region
353..385; Disordered; P35613-2:195..199; Essential for interaction with KDR/VEGFR2
Clinical Relevance
Related Diseases
Biomarker
Phase 2/3; Phase 2; Phase 1/2
Drug Targets
Clinical trial target
Interaction Protein
ENSG00000070961ENSG00000127022ENSG00000155380ENSG00000196262
Interaction Count
4
Interaction Dataset
biogrid_opencellintact_biogrid