Protein detail

MYH11

Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)

Entry name MYH11	UniProt ID P35749	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification Cancer-related genesCandidate cardiovascular disease genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)

Protein Class (6)

Cancer-related genesCandidate cardiovascular disease genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins

Protein Function (6)

Human disease related genes:Cardiovascular diseases:Vascular diseases
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
Candidate cardiovascular disease genes
Cancer-related genes
Disease related genes

Ensembl

ENSG00000133392

Entrez Gene Symbol

MYH11

Gene Synonym (3)

SMHCSMMHCSMMS-1

Gene Description

Myosin heavy chain 11

Chromosome

Position

15703135-15857028

Supporting publications (n)

EVMP confidence score

0.38

Function & Pathway7

Protein Function (6)

Human disease related genes:Cardiovascular diseases:Vascular diseases
Predicted intracellular proteins
Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
Candidate cardiovascular disease genes
Cancer-related genes
Disease related genes

Cellular Component (7)

Molecular Function (6)

Biological Process (3)

KEGG (8)

Reactome (18)

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Mediation Categories (2)

Fusion and delivery mediationReceptor-signaling mediation

Relations & Evidence12

Ligand-Receptor Signaling (9)

9 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
ecm	ecm	GO_Intercell	Yes	No	No	No	No
ecm	ecm	OmniPath	Yes	No	No	No	No
extracellular	extracellular	LOCATE	No	No	No	No	No
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	LOCATE	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No

Protein Complex Composition (2)

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	MYH11 RWDD2B	P35749 P57060	0:0	hu.MAP
	MYH11 OVCA2	P35749 Q8WZ82	0:0	hu.MAP

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow Filtration	Mass spectrometry	4	28054239 38731868 26196085 37686366

Sequence, Structure & Domains13

Sequences

Length

1,972

Mass

227,339

Sequence

MAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE

Alternative Products

Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SM-A; IsoId=P35749-1; Sequence=Displayed; Name=2; Synonyms=SM-B1; IsoId=P35749-2; Sequence=VSP_043017; Name=3; Synonyms=SM-B2; IsoId=P35749-3; Sequence=VSP_043017, VSP_043018; Name=4; IsoId=P35749-4; Sequence=VSP_043018

Alternative Sequence

211; T -> TQGPSFAY (in isoform 2 and isoform 3); 1930..1972; RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE -> GPPPQETSQ (in isoform 3 and isoform 4)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Compositional Bias

1762..1788; Polar residues; 1789..1800; Basic and acidic residues; 1866..1876; Basic and acidic residues

Coiled Coil

844..1934

Domain (CC)

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.; DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).

Domain (FT)

31..81; Myosin N-terminal SH3-like; 85..783; Myosin motor; 786..815; IQ

Region

661..683; Actin-binding; 762..776; Actin-binding; 858..882; Disordered; 1744..1800; Disordered; 1866..1972; Disordered; 1935..1972; C-terminal

Protein Families (2)

TRAFAC class myosin-kinesin ATPase superfamily
Myosin family

Sequence Similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.

Clinical Relevance2

Disease Involvement (4)

Aortic aneurysmCancer-related genesDisease variantProto-oncogene

Antibody (3)

CAB002302 HPA014539 HPA015310

Supporting Publications2

PMID	Title	Abstract
37016580	Epsin1-mediated exosomal sorting of Dll4 modulates the tubular-macrophage crosstalk in diabetic nephropathy.	By mass spectrometry, 1,644 differentially expressed proteins, especially Dll4, were detected in the urine exosomes of DN patients compared with controls, which was confirmed by western blot assay.
37767799	Exosome miR-30a-5p Regulates Glomerular Endothelial Cells' EndMT and Angiogenesis by Modulating Notch1/VEGF Signaling Pathway.	Exosome miR-30a-5p reduced the expression levels of Notch1 and VEGF, both at mRNA and protein levels.