Protein detail
MYH11
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Entry name MYH11 | UniProt ID | EVMP score 0.38 |
Frequency 2 | Transmembrane count | Protein classification Cancer-related genesCandidate cardiovascular disease genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Myosin-11 (Myosin heavy chain 11) (Myosin heavy chain, smooth muscle isoform) (SMMHC)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesDisease related genesHuman disease related genesPlasma proteinsPredicted intracellular proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Candidate cardiovascular disease genes
- Cancer-related genes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
SMHCSMMHCSMMS-1
Gene Description
Myosin heavy chain 11
Chromosome
16
Position
15703135-15857028
Frequency
2
EVMP Score
0.38
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Predicted intracellular proteins
- Human disease related genes:Congenital malformations:Congenital malformations of the digestive system
- Candidate cardiovascular disease genes
- Cancer-related genes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
- hsa03273 Virion - Lassa virus and SFTS virus
- KEGG:hsa04270 Vascular smooth muscle contraction
- KEGG:hsa04517 IgSF CAM signaling
- KEGG:hsa04530 Tight junction
- KEGG:hsa04810 Regulation of actin cytoskeleton
- KEGG:hsa04814 Motor proteins
- KEGG:hsa04820 Cytoskeleton in muscle cells
- KEGG:hsa05130 Pathogenic Escherichia coli infection
Reactome
- R-hsa-9734767 developmental cell lineages
- R-hsa-9734779 developmental cell lineages of the integumentary system
- R-hsa-9924644 developmental lineages of the mammary gland
- R-hsa-9927432 developmental lineage of mammary gland myoepithelial cells
- R-hsa-3928663 epha mediated growth cone collapse
- R-hsa-2682334 eph ephrin signaling
- R-hsa-397014 muscle contraction
- R-hsa-9675108 nervous system development
- R-hsa-5625900 rho gtpases activate cit
- R-hsa-5627123 rho gtpases activate paks
- R-hsa-5625740 rho gtpases activate pkns
- R-hsa-5627117 rho gtpases activate rocks
- R-hsa-195258 rho gtpase effectors
- R-hsa-416572 sema4d induced cell migration and growth cone collapse
- R-hsa-400685 sema4d in semaphorin signaling
- R-hsa-373755 semaphorin interactions
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-445355 smooth muscle contraction
Mediation Categories
Fusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
9 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ecm | ecm | GO_Intercell | Yes | No | No | No | No |
| ecm | ecm | OmniPath | Yes | No | No | No | No |
| extracellular | extracellular | LOCATE | No | No | No | No | No |
| extracellular | extracellular | OmniPath | No | No | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
1,972
Mass
227,339
Sequence
MAQKGQLSDDEKFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVENGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKHLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTSITGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDERTFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQLSILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQKAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEECWFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=SM-A; IsoId=P35749-1; Sequence=Displayed; Name=2; Synonyms=SM-B1; IsoId=P35749-2; Sequence=VSP_043017; Name=3; Synonyms=SM-B2; IsoId=P35749-3; Sequence=VSP_043017, VSP_043018; Name=4; IsoId=P35749-4; Sequence=VSP_043018
Alternative Sequence
211; T -> TQGPSFAY (in isoform 2 and isoform 3); 1930..1972; RGNETSFVPSRRSGGRRVIENADGSEEETDTRDADFNGTKASE -> GPPPQETSQ (in isoform 3 and isoform 4)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Compositional Bias
1762..1788; Polar residues; 1789..1800; Basic and acidic residues; 1866..1876; Basic and acidic residues
Coiled Coil
844..1934
Domain (CC)
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.; DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).
Domain (FT)
31..81; Myosin N-terminal SH3-like; 85..783; Myosin motor; 786..815; IQ
Region
661..683; Actin-binding; 762..776; Actin-binding; 858..882; Disordered; 1744..1800; Disordered; 1866..1972; Disordered; 1935..1972; C-terminal
Protein Families
- TRAFAC class myosin-kinesin ATPase superfamily
- Myosin family
Sequence Similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.