Protein detail
TGFR1
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Protein symbol TGFR1 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins |
Basic Information
Protein Names
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Protein Class
Disease related genesEnzymesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
Transmembrane
127..147; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
ACVRLK4ALK-5ALK5ESS1MSSETBR-iTBRI
Gene Description
Transforming growth factor beta receptor 1
Chromosome
9
Position
99104038-99154192
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- Human disease related genes:Cancers:Cancers of the digestive system
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
Cellular Component
Molecular Function
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0004675 transmembrane receptor protein serine/threonine kinase activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005025 transforming growth factor beta receptor activity, type I
- GO:0005114 type II transforming growth factor beta receptor binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016361 activin receptor activity, type I
- GO:0019838 growth factor binding
- GO:0031625 ubiquitin protein ligase binding
- GO:0046332 SMAD binding
- GO:0046872 metal ion binding
- GO:0048185 activin binding
- GO:0050431 transforming growth factor beta binding
- GO:0070411 I-SMAD binding
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04218 Cellular senescence
- KEGG:hsa04350 TGF-beta signaling pathway
- KEGG:hsa04371 Apelin signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05210 Colorectal cancer
- KEGG:hsa05212 Pancreatic cancer
- KEGG:hsa05220 Chronic myeloid leukemia
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
- KEGG:hsa05415 Diabetic cardiomyopathy
Reactome
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-2173788 downregulation of tgf beta receptor signaling
- R-hsa-3304349 loss of function of smad2 3 in cancer
- R-hsa-597592 post translational protein modification
- R-hsa-9839373 signaling by tgfbr3
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-3304351 signaling by tgf beta receptor complex in cancer
- R-hsa-9839389 tgfbr3 regulates tgf beta signaling
- R-hsa-2173789 tgf beta receptor signaling activates smads
- R-hsa-2173791 tgf beta receptor signaling in emt epithelial to mesenchymal transition
- R-hsa-5689880 ub specific processing proteases
- R-hsa-5689603 uch proteinases
Mediation Categories
Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
17 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TGFBR1 | TGFBR2 | P37173 | T | 176 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:8576253KEA:8576253ProtMapper:8576253SIGNOR:8576253 |
| TGFBR1 | TGFBR2 | P37173 | S | 187 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:7774578 |
| TGFBR1 | TGFBR2 | P37173 | S | 189 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:7774578 |
| TGFBR1 | TGFBR2 | P37173 | S | 191 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:7774578 |
| TGFBR1 | TGFBR2 | P37173 | T | 185 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:7774578 |
| TGFBR1 | TGFBR2 | P37173 | T | 186 | phosphorylation | PhosphoSite_MIMPMIMPProtMapperdbPTMPhosphoSitePhosphoSite_ProtMapper | dbPTM:7774578 |
| TGFBR1 | TGFBR2 | P37173 | T | 204 | phosphorylation | SIGNOR_ProtMapperSIGNORProtMapper | ProtMapper:7774578SIGNOR:7774578 |
| TGFBR1 | TGFBR2 | P37173 | T | 200 | phosphorylation | SIGNOR_ProtMapperPhosphoSiteSIGNORProtMapper | SIGNOR:8576253ProtMapper:7774578ProtMapper:8576253SIGNOR:7774578 |
| TGFBR1 | TGFBR2 | P37173 | S | 172 | phosphorylation | PhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:8576253KEA:8576253ProtMapper:8576253SIGNOR:8576253 |
| TGFBR1 | TGFBR2 | P37173 | S | 165 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:22802914 |
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Ligand-Receptor Signaling
71 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | Yes | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | Yes | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | GO_Intercell | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | Ramilowski_location | Yes | Yes | No | Yes | No |
| tight_junction | tight_junction | OmniPath | Yes | Yes | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane_predicted | transmembrane | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
41 records.
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Protein Complex Composition
5 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| TGF-beta receptor I-Axin-SMAD3 complex | AXIN1SMAD3TGFBR1 | O15169P36897P84022 | 1:1:1 | CompleatCORUM | Compleat:HC3522CORUM:1828 | 11438668 |
| Ubiquitin E3 ligase (SMAD7SMURF1) - TGFBR1 | SMAD7SMURF1TGFBR1 | O15105P36897Q9HCE7 | 1:1:1 | CompleatCORUM | Compleat:HC2631CORUM:1783 | 11278251 |
| TGFBR1 | P36897 | 5 | PDB | PDB:3kcfPDB:3faaPDB:1iasPDB:2x7o | ||
| FKBP1ATGFBR1 | P36897P62942 | 4:4 | PDB | PDB:1b6c | ||
| ACVR1TGFBR1 | P36897Q04771 | 0:0 | CellinkerICELLNET | 29376829 |
Sequence, Structure & Domains
Sequences
Length
503
Mass
55,960
Sequence
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPGLGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P36897-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=P36897-2; Sequence=VSP_041326; Name=3; IsoId=P36897-3; Sequence=VSP_041327
Alternative Sequence
114; T -> TGPFS (in isoform 2); 115..191; Missing (in isoform 3)
3D Structural Models
Turn
42..46; 84..86; 360..363; 427..431
Helix
74..76; 107..109; 177..183; 202..204; 236..238; 239..249; 288..294; 299..317; 336..338; 352..354; 376..378; 381..384; 393..413; 438..445; 456..460; 462..474; 479..481; 485..497
Beta Strand
35..37; 47..49; 51..63; 65..72; 77..79; 89..91; 94..101; 102..105; 187..190; 191..193; 205..213; 215..224; 227..234; 251..253; 262..269; 271..281; 322..324; 328..330; 339..341; 347..349; 356..359; 364..367; 368..371; 417..419
3D Structure
Electron microscopy (1); NMR spectroscopy (1); X-ray crystallography (42)
Domain & Motif Annotations
Motif
193..194; FKBP1A-binding
Domain (FT)
175..204; GS; 205..495; Protein kinase
Protein Families
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance
Disease Involvement
Aortic aneurysmCraniosynostosisDisease variant
Related Diseases
Biomarker
Phase 2/3; Phase 1/2; Investigative; Terminated; Preclinical; Phase 2; Phase 1
Drugs
Interaction Protein
ENSG00000088832ENSG00000127022
Interaction Count
2
Interaction Dataset
intact_biogridbiogrid_opencell