Protein detail
TGFR2
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Entry name TGFR2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Predicted secreted proteins
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- FDA approved drug targets:Biotech drugs
Transmembrane
167..187; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Cancer-related genes:Mutational cancer driver genes
- Human disease related genes:Cancers:Cancers of the digestive system
- Human disease related genes:Cardiovascular diseases:Vascular diseases
- ENZYME proteins:Transferases
- Cancer-related genes:Mutated cancer genes
- Human disease related genes:Congenital malformations:Congenital malformations of the circulatory system
- Enzymes
- Predicted secreted proteins
- Kinases:TKL Ser/Thr protein kinases
- Disease related genes
- FDA approved drug targets:Biotech drugs
Cellular Component
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0005901 caveola
- GO:0009897 external side of plasma membrane
- GO:0016020 membrane
- GO:0043235 receptor complex
- GO:0045121 membrane raft
- GO:0070021 transforming growth factor beta ligand-receptor complex
Molecular Function
- GO:0004674 protein serine/threonine kinase activity
- GO:0004675 transmembrane receptor protein serine/threonine kinase activity
- GO:0005024 transforming growth factor beta receptor activity
- GO:0005026 transforming growth factor beta receptor activity, type II
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0005539 glycosaminoglycan binding
- GO:0017002 activin receptor activity
- GO:0019209 kinase activator activity
- GO:0034713 type I transforming growth factor beta receptor binding
- GO:0034714 type III transforming growth factor beta receptor binding
- GO:0046332 SMAD binding
- GO:0046872 metal ion binding
- GO:0048185 activin binding
- GO:0050431 transforming growth factor beta binding
- GO:0060090 molecular adaptor activity
Biological Process
KEGG
- hsa04010 MAPK signaling pathway
- KEGG:hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04068 FoxO signaling pathway
- KEGG:hsa04144 Endocytosis
- KEGG:hsa04218 Cellular senescence
- KEGG:hsa04350 TGF-beta signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04390 Hippo signaling pathway
- KEGG:hsa04520 Adherens junction
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa04926 Relaxin signaling pathway
- KEGG:hsa04933 AGE-RAGE signaling pathway in diabetic complications
- KEGG:hsa05142 Chagas disease
- KEGG:hsa05161 Hepatitis B
- KEGG:hsa05166 Human T-cell leukemia virus 1 infection
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05202 Transcriptional misregulation in cancer
- KEGG:hsa05210 Colorectal cancer
- KEGG:hsa05212 Pancreatic cancer
- KEGG:hsa05220 Chronic myeloid leukemia
- KEGG:hsa05225 Hepatocellular carcinoma
- KEGG:hsa05226 Gastric cancer
- KEGG:hsa05415 Diabetic cardiomyopathy
Reactome
- R-hsa-5688426 deubiquitination
- R-hsa-5663202 diseases of signal transduction by growth factor receptors and second messengers
- R-hsa-2173788 downregulation of tgf beta receptor signaling
- R-hsa-3304349 loss of function of smad2 3 in cancer
- R-hsa-597592 post translational protein modification
- R-hsa-9839373 signaling by tgfbr3
- R-hsa-9006936 signaling by tgfb family members
- R-hsa-170834 signaling by tgf beta receptor complex
- R-hsa-3304351 signaling by tgf beta receptor complex in cancer
- R-hsa-9839389 tgfbr3 regulates tgf beta signaling
- R-hsa-2173789 tgf beta receptor signaling activates smads
- R-hsa-2173791 tgf beta receptor signaling in emt epithelial to mesenchymal transition
- R-hsa-5689603 uch proteinases
Canonical Pathways
M141 Pid pi3kci pathway
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
3 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TGFBR2 | SRC | P12931 | Y | 284 | phosphorylation | Sparser_ProtMapperSIGNORProtMapperRLIMS-P_ProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:16859511SIGNOR:19114990ProtMapper:26357075ProtMapper:17440088ProtMapper:21532881ProtMapper:19114990 |
| TGFBR2 | SRC | P12931 | Y | 309 | phosphorylation | MIMPPhosphoSite_MIMP | |
| TGFBR2 | CSNK1D | P48730 | S | 213 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling
71 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| act_tgfb | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| cytokine | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| cytokine_tgf | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| receptor | receptor | OmniPath | No | Yes | Yes | Yes | No |
| extracellular | extracellular | HPMR | No | No | Yes | Yes | No |
| extracellular | extracellular | DGIdb | No | No | Yes | Yes | No |
| extracellular | extracellular | OmniPath | No | No | Yes | Yes | No |
| intracellular | intracellular | LOCATE | No | No | Yes | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | Yes | Yes | No |
| intracellular | intracellular | OmniPath | No | No | Yes | Yes | No |
Regulatory Interaction Network
20 records.
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Protein Complex Composition
6 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| ACVR1B_TGFbR2 | ACVR1BTGFBR2 | P36896P37173 | 0:0 | CellinkerCellChatDB | ||
| ACVR1C_TGFbR2 | ACVR1CTGFBR2 | P37173Q8NER5 | 0:0 | CellinkerCellChatDB | ||
| TGF-beta receptor II-TGF-beta3 complex | TGFB3TGFBR2 | P10600P37173 | 1:1 | CompleatCORUMPDB | CORUM:3025Compleat:HC656PDB:1ktz | 1628957611850637 |
| TGF-beta-receptor type II homodimer complex | TGFBR2 | P37173 | 0 | CORUM | CORUM:3041 | 7521335 |
| TGFbeta_receptor2 | ACVR1TGFBR2 | P37173Q04771 | 1:1 | CellPhoneDB | CellPhoneDB:TGFbeta_receptor2 | |
| TGFB2TGFBR2 | P37173P61812 | 1:1 | PDB | PDB:5tx4PDB:5ty4 |
Sequence, Structure & Domains
Sequences
Length
567
Mass
64,568
Sequence
MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSVNNDMIVTDNNGAVKFPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSDECNDNIIFSEEYNTSNPDLLLVIFQVTGISLLPPLGVAISVIIIFYCYRVNRQQKLSSTWETGKTRKLMEFSEHCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRLSGRSCSEEKIPEDGSLNTTK
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=betaR-II; IsoId=P37173-1; Sequence=Displayed; Name=2; Synonyms=betaR-IIB; IsoId=P37173-2; Sequence=VSP_012157; Name=3; Synonyms=TbetaRII-SE; IsoId=P37173-3; Sequence=VSP_061513, VSP_061514
Alternative Sequence
31..32; SV -> SDVEMEAQKDEIICPSCNRTAHPLRHI (in isoform 2); 68..80; MSNCSITSICEKP -> FSKVHYEGKKKAW (in isoform 3); 81..567; Missing (in isoform 3)
3D Structural Models
Turn
114..117; 297..299; 473..477; 492..494
Helix
143..145; 151..153; 281..283; 284..294; 333..339; 344..362; 382..384; 410..413; 422..424; 427..430; 440..459; 462..464; 484..491; 502..506; 508..520; 525..527; 531..539
Beta Strand
40..45; 50..52; 55..58; 65..68; 74..76; 78..81; 83..90; 95..102; 104..106; 108..110; 119..122; 124..126; 131..138; 140..142; 146..148; 244..252; 257..263; 267..269; 272..280; 307..315; 318..326; 385..387; 393..395
3D Structure
Electron microscopy (4); NMR spectroscopy (1); X-ray crystallography (17)
Domain & Motif Annotations
Domain (FT)
244..544; Protein kinase
Region
439..567; Sufficient for interaction with CLU
Protein Families
- Protein kinase superfamily
- TKL Ser/Thr protein kinase family
- TGFB receptor subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Clinical Relevance
Related Diseases
Biomarker
Phase 1
Interaction Protein
ENSG00000119699ENSG00000136536ENSG00000179820
Interaction Count
3
Interaction Dataset
intact_biogridbiogrid_bioplex