Protein detail
GRIK1
Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
Entry name GRIK1 | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 1 | Transmembrane count 3 | Protein classification FDA approved drug targetsPredicted membrane proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Glutamate receptor ionotropic, kainate 1 (GluK1) (Excitatory amino acid receptor 3) (EAA3) (Glutamate receptor 5) (GluR-5) (GluR5)
Protein Class (2)
FDA approved drug targetsPredicted membrane proteins
Protein Function
FDA approved drug targets:Small molecule drugs
Transmembrane
577..597; Helical; 654..674; Helical; 835..855; Helical
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
GluK1GLUR5
Gene Description
Glutamate ionotropic receptor kainate type subunit 1
Chromosome
21
Position
29536933-29940033
Supporting publications (n)
1
EVMP confidence score
0.50
Fluorescence & Localization5
Tissue Specificbone marrowCell SpecificB-cellsSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell Specificbasophil
Function & Pathway7
Protein Function
FDA approved drug targets:Small molecule drugs
Cellular Component (5)
Molecular Function (4)
Biological Process (3)
KEGG (3)
Reactome (5)
Mediation Categories (3)
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence37
Ligand-Receptor Signaling (32)
32 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| ion_channel | ion_channel | DGIdb | No | Yes | No | No | No |
| ligand_gated | ion_channel | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | No | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
Protein Complex Composition (4)
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GLUK1-GLUK2 glutamate ionotropic kainate-type receptor complex | GRIK1GRIK2 | P39086Q13002 | 1:1 | ComplexPortal | intact:EBI-48421736 | 14755292 |
| GLUK1-GLUK2-GLUK4 glutamate ionotropic kainate-type receptor complex | GRIK1GRIK2GRIK4 | P39086Q13002Q16099 | 1:1:1 | ComplexPortal | 1475529234706237 | |
| GluK1 glutamate ionotropic kainate-type receptor complex | GRIK1 | P39086 | 2 | ComplexPortalPDB | PDB:4mf3PDB:3fvointact:EBI-48420380PDB:3FUZPDB:3fv1PDB:3fvnPDB:3fuzPDB:3fvkPDB:3fvgPDB:3FV2PDB:3fv2PDB:3FV1 | 218930691475529234706237 |
| Glutamate_Kainate_1_4_complex | GRIK1GRIK4 | P39086Q16099 | 1:1 | CellPhoneDBCellChatDBComplexPortal | CellPhoneDB:Glutamate_Kainate_1_4_complex | 1475529234706237 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains11
Sequences
Length
918
Mass
103,981
Sequence
MEHGTLLAQPGLWTRDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIEQAFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIRKQSSVHTV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Comment=Additional isoforms seem to exist.; Name=1; Synonyms=GluR5-1D; IsoId=P39086-1; Sequence=Displayed; Name=2; Synonyms=EAA3A; IsoId=P39086-2; Sequence=VSP_000127, VSP_000128
Alternative Sequence
402..416; Missing (in isoform 2); 870..918; AFCFFYGLQCKQTHPTNSTSGTTLSTDLECGKLIREERGIRKQSSVHTV -> CLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCHQRRTQRKETVA (in isoform 2)
3D Structural Models
Turn
457..459
Helix
471..474; 478..490; 515..521; 536..539; 686..691; 704..711; 715..726; 728..731; 736..745; 754..761; 790..802; 805..814
Beta Strand
449..453; 460..462; 475..477; 494..498; 526..528; 542..544; 548..551; 553..559; 693..698; 732..735; 746..753; 767..771; 777..779; 782..784
3D Structure
X-ray crystallography (11)
Domain & Motif Annotations
Protein Families (2)
- Glutamate-gated ion channel (TC 1.A.10.1) family
- GRIK1 subfamily
Sequence Similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK1 subfamily.
Clinical Relevance6
Disease Involvement
FDA approved drug targets
Related Diseases (5)
Biomarker
Phase 1; Approved; Phase 2
Drug Targets (5)
FDA approved drug targetsClinical trial targetSuccessful targetDiscontinued targetLiterature-reported target
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 37446098 | Glypican-3 (GPC-3) Structural Analysis and Cargo in Serum Small Extracellular Vesicles of Hepatocellular Carcinoma Patients. | No abstract available |