Protein detail

TYRP2

L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)

Entry name TYRP2	UniProt ID P40126	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (6)

Transporters
ENZYME proteins:Isomerase
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Transmembrane

473..493; Helical

Transmembrane Count

Ensembl

ENSG00000080166

Entrez Gene Symbol

DCT

Gene Synonym (3)

TRP-2TRP2TYRP2

Gene Description

Dopachrome tautomerase

Chromosome

Position

94436811-94479682

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (6)

Transporters
ENZYME proteins:Isomerase
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component (6)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (5)

Mediation Categories

Metabolism mediation

Relations & Evidence36

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
intracellular	intracellular	ComPPI	No	No	No	Yes	No
intracellular	intracellular	GO_Intercell	No	No	No	Yes	No
intracellular	intracellular	UniProt_location	No	No	No	Yes	No
intracellular	intracellular	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_location	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_topology	No	No	No	Yes	No
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No

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Protein Complex Composition (20)

20 records.

Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs
CLIP1 DCTN1	P30622 Q14203	4:4	PDB	PDB:2hqhPDB:3e2u
DCTD	P32321	6	PDB	PDB:2w4l
CIAPIN1 DCTPP1 ENY2 HSPB8 PPP1R2	P41236 Q6FI81 Q9H773 Q9NPA8 Q9UJY1	0:0:0:0:0	Havugimana2012	Havugimana2012:C_475
BTRC DCTN2 MXRA7 NAA20 SKP1 TBC1D17	P61599 P63208 P84157 Q13561 Q9HA65 Q9Y297	1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7757
BTRC DCTN2 MXRA7 SPART TBC1D17	P84157 Q13561 Q8N0X7 Q9HA65 Q9Y297	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5149
DCTN1 DST DTNBP1	Q03001 Q14203 Q96EV8	1:1:1	CompleatCFinder	Compleat:HC5145
DCTN1	Q14203	2	PDB	PDB:2hkn
DCTN1 MAPRE1	Q14203 Q15691	2:1	PDB	PDB:2hl5PDB:2hkqPDB:2hl3PDB:1txq
DCTN1 MAPRE1 MAPRE3	Q14203 Q15691 Q9UPY8	2:1:1	PDB	PDB:3tq7
DCTPP1	Q9H773	8	PDB	PDB:7mu5

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	3	38113368 41307968 38207106

Sequence, Structure & Domains8

Sequences

Length

519

Mass

59,145

Sequence

MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40126-1; Sequence=Displayed; Name=2; Synonyms=TRP-2-6b; IsoId=P40126-2; Sequence=VSP_043581

Alternative Sequence

393; V -> VVISNRLLYNATTNILEHVRKEKATKELPSLHVL (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

Tyrosinase family

Sequence Similarities

Belongs to the tyrosinase family.

Clinical Relevance3

Disease Involvement (2)

AlbinismDisease variant

Drugs (6)

TP0556351 CGS-27023A COMPOUND 29E [PMID: 23631440](R)-ND-336 AMPHOTERICIN B LIPOSOMAL ILOMASTAT

Antibody (4)

HPA010742 HPA010743 HPA010800 CAB017634

Supporting Publications1

PMID	Title	Abstract
40740986	Proteomics analysis reveals elevated RAB21 in serum-derived extracellular vesicles from patients with follicular thyroid carcinoma.	No abstract available