Protein detail
TYRP2
L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)
Entry name TYRP2 | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)
Protein Class
Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Transporters
- ENZYME proteins:Isomerase
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Transmembrane
473..493; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
TRP-2TRP2TYRP2
Gene Description
Dopachrome tautomerase
Chromosome
13
Position
94436811-94479682
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- Transporters
- ENZYME proteins:Isomerase
- Potential drug targets
- Enzymes
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component
Molecular Function
Biological Process
Reactome
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
15 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | UniProt_location | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
Page 1 of 2Next
Regulatory Interaction Network
0 records.
Protein Complex Composition
20 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| CLIP1DCTN1 | P30622Q14203 | 4:4 | PDB | PDB:2hqhPDB:3e2u | ||
| DCTD | P32321 | 6 | PDB | PDB:2w4l | ||
| CIAPIN1DCTPP1ENY2HSPB8PPP1R2 | P41236Q6FI81Q9H773Q9NPA8Q9UJY1 | 0:0:0:0:0 | Havugimana2012 | Havugimana2012:C_475 | ||
| BTRCDCTN2MXRA7NAA20SKP1TBC1D17 | P61599P63208P84157Q13561Q9HA65Q9Y297 | 1:1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC7757 | ||
| BTRCDCTN2MXRA7SPARTTBC1D17 | P84157Q13561Q8N0X7Q9HA65Q9Y297 | 1:1:1:1:1 | NetworkBlastCompleat | Compleat:HC5149 | ||
| DCTN1DSTDTNBP1 | Q03001Q14203Q96EV8 | 1:1:1 | CompleatCFinder | Compleat:HC5145 | ||
| DCTN1 | Q14203 | 2 | PDB | PDB:2hkn | ||
| DCTN1MAPRE1 | Q14203Q15691 | 2:1 | PDB | PDB:2hl5PDB:2hkqPDB:2hl3PDB:1txq | ||
| DCTN1MAPRE1MAPRE3 | Q14203Q15691Q9UPY8 | 2:1:1 | PDB | PDB:3tq7 | ||
| DCTPP1 | Q9H773 | 8 | PDB | PDB:7mu5 |
Page 2 of 2Previous
Sequence, Structure & Domains
Sequences
Length
519
Mass
59,145
Sequence
MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40126-1; Sequence=Displayed; Name=2; Synonyms=TRP-2-6b; IsoId=P40126-2; Sequence=VSP_043581
Alternative Sequence
393; V -> VVISNRLLYNATTNILEHVRKEKATKELPSLHVL (in isoform 2)
3D Structural Models
3D Structure
X-ray crystallography (1)
Domain & Motif Annotations
Protein Families
Tyrosinase family
Sequence Similarities
Belongs to the tyrosinase family.
Clinical Relevance
Disease Involvement
AlbinismDisease variant