Protein detail

TYRP2

L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)

Entry name TYRP2	UniProt ID P40126	EVMP confidence score 0.50
Supporting publications (n) 1	Transmembrane count 1	Protein classification Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information13

Protein Names

L-dopachrome tautomerase (DCT) (DT) (EC 5.3.3.12) (L-dopachrome Delta-isomerase) (Tyrosinase-related protein 2) (TRP-2) (TRP2)

Protein Class (7)

Disease related genesEnzymesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters

Protein Function (6)

Transporters
ENZYME proteins:Isomerase
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Transmembrane

473..493; Helical

Transmembrane Count

Ensembl

ENSG00000080166

Entrez Gene Symbol

DCT

Gene Synonym (3)

TRP-2TRP2TYRP2

Gene Description

Dopachrome tautomerase

Chromosome

Position

94436811-94479682

Supporting publications (n)

EVMP confidence score

0.50

Function & Pathway7

Protein Function (6)

Transporters
ENZYME proteins:Isomerase
Potential drug targets
Enzymes
Disease related genes
Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism

Cellular Component (6)

Molecular Function (4)

Biological Process (3)

KEGG (3)

Reactome (5)

Mediation Categories

Metabolism mediation

Relations & Evidence36

Ligand-Receptor Signaling (15)

15 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	OmniPath	No	No	No	Yes	No
cell_surface	cell_surface	Surfaceome	No	No	No	Yes	No
cell_surface	cell_surface	OmniPath	No	No	No	Yes	No
transmembrane	transmembrane_predicted	Phobius	No	No	No	Yes	No

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Protein Complex Composition (20)

20 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
Dynactin complex (DCTN1DCTN2DCTN3DCTN4DCTN6CAPZA1CAPZBACTR1A)	ACTR1A CAPZA1 CAPZB DCTN1 DCTN2 DCTN3 DCTN4 DCTN6	O00399 O75935 P47756 P52907 P61163 Q13561 Q14203 Q9UJW0	1:1:1:1:1:1:1:1	Compleat	Compleat:HC3107	10074429
Dynein-dynactin complex	DCTN1 DYNC1H1 DYNC1I1 DYNC1LI1 DYNLL1	O14576 P63167 Q14203 Q14204 Q9Y6G9	0:0:0:0:0	CORUM	CORUM:6039	17403682
Htt-Dctn1-Hap1 complex	DCTN1 HAP1 HTT	P42858 P54257 Q14203	1:1:1	Compleat	Compleat:HC1779	15242649
Lebercilin complex (Lca5NclNpm1YwhaeHSPA1A/BDctn1Dctn2)	CLEC2D DCTN1 DCTN2 LCA5 NCL NPM1 YWHAB YWHAE YWHAZ	P06748 P19338 P31946 P62258 P63104 Q13561 Q14203 Q86VQ0 Q9UHP7	1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC2274	17546029
cytoplasmic dynein complex	DCTN1 DYNC1H1 DYNC1I1 DYNC1LI1 DYNC1LI2 DYNLL1 DYNLRB1 DYNLRB2 DYNLT1 DYNLT3 SNX4	O14576 O43237 O95219 P51808 P63167 P63172 Q14203 Q14204 Q8TF09 Q9NP97 Q9Y6G9	1:1:1:1:1:1:1:1:1:1:1	Compleat	Compleat:HC742	11750132 7738094 17994011 19229290 8666668 11425878
	DCTN6	O00399	2	PDB	PDB:3tv0
	CPSF6 CTRL DCTD NUDT21 TCERG1 TP63 WWOX	O14776 O43809 P32321 P40313 Q16630 Q9H3D4 Q9NZC7	1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC5535
	ACTR1A ACTR1B DCTN2 DCTN3 DYNC1LI2 DYNLT3	O43237 O75935 P42025 P51808 P61163 Q13561	0:0:0:0:0:0	Havugimana2012	Havugimana2012:C_520
	DCTN1 DCTN3 GSK3B UBC	O75935 P0CG48 P49841 Q14203	1:1:1:1	CompleatCFinder	Compleat:HC3911
	BTRC DCTN2 GABARAP MXRA7 TBC1D17	O95166 P84157 Q13561 Q9HA65 Q9Y297	1:1:1:1:1	NetworkBlastCompleat	Compleat:HC6377

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Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture	Mass spectrometry	3	38113368 41307968 38207106

Sequence, Structure & Domains8

Sequences

Length

519

Mass

59,145

Sequence

MSPLWWGFLLSCLGCKILPGAQGQFPRVCMTVDSLVNKECCPRLGAESANVCGSQQGRGQCTEVRADTRPWSGPYILRNQDDRELWPRKFFHRTCKCTGNFAGYNCGDCKFGWTGPNCERKKPPVIRQNIHSLSPQEREQFLGALDLAKKRVHPDYVITTQHWLGLLGPNGTQPQFANCSVYDFFVWLHYYSVRDTLLGPGRPYRAIDFSHQGPAFVTWHRYHLLCLERDLQRLIGNESFALPYWNFATGRNECDVCTDQLFGAARPDDPTLISRNSRFSSWETVCDSLDDYNHLVTLCNGTYEGLLRRNQMGRNSMKLPTLKDIRDCLSLQKFDNPPFFQNSTFSFRNALEGFDKADGTLDSQVMSLHNLVHSFLNGTNALPHSAANDPIFVVLHSFTDAIFDEWMKRFNPPADAWPQELAPIGHNRMYNMVPFFPPVTNEELFLTSDQLGYSYAIDLPVSVEETPGWPTTLLVVMGTLVALVGLFVLLAFLQYRRLRKGYTPLMETHLSSKRYTEEA

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40126-1; Sequence=Displayed; Name=2; Synonyms=TRP-2-6b; IsoId=P40126-2; Sequence=VSP_043581

Alternative Sequence

393; V -> VVISNRLLYNATTNILEHVRKEKATKELPSLHVL (in isoform 2)

3D Structural Models

3D Structure

X-ray crystallography (1)

Domain & Motif Annotations

Protein Families

Tyrosinase family

Sequence Similarities

Belongs to the tyrosinase family.

Clinical Relevance3

Disease Involvement (2)

AlbinismDisease variant

Drugs (6)

TP0556351 CGS-27023A COMPOUND 29E [PMID: 23631440](R)-ND-336 AMPHOTERICIN B LIPOSOMAL ILOMASTAT

Antibody (4)

HPA010742 HPA010743 HPA010800 CAB017634

Supporting Publications1

PMID	Title	Abstract
40740986	Proteomics analysis reveals elevated RAB21 in serum-derived extracellular vesicles from patients with follicular thyroid carcinoma.	No abstract available