Protein detail

IL6RB

Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)

Entry name
IL6RB
UniProt ID
P40189
EVMP score
0.50
Frequency
1
Transmembrane count
1
Protein classification
Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
  • Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
  • CD markers
  • Candidate cardiovascular disease genes
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted secreted proteins
  • Disease related genes
Transmembrane
620..641; Helical
Transmembrane Count
1
Ensembl
ENSG00000134352
Entrez Gene Symbol
IL6ST
Gene Synonym
CD130GP130IL-6RBsGP130
Gene Description
Interleukin 6 cytokine family signal transducer
Chromosome
5
Position
55935095-55995022
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificeccentric medium spiny neuron
Function & Pathway
Protein Function
  • Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
  • CD markers
  • Candidate cardiovascular disease genes
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Cancer-related genes:Candidate cancer biomarkers
  • Predicted secreted proteins
  • Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence

Enzyme-Mediated Modification

18 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
IL6STCAMK2AQ9UQM7S782phosphorylationPhosphoSite
IL6STCAMK2AQ9UQM7S780phosphorylationKEAKEA:16036214
IL6STEGFP01133S667phosphorylationBEL-Large-Corpus_ProtMapperProtMapperProtMapper:17081983
IL6STMAPKAPK2P49137S782phosphorylationRLIMS-P_ProtMapperProtMapperProtMapper:20200229
IL6STLIFP15018S782phosphorylationSparser_ProtMapperProtMapperProtMapper:10811661
IL6STCAMK2GQ13555S782phosphorylationSparser_ProtMapperProtMapperProtMapper:22306348
IL6STSOCS3O14543Y759phosphorylationREACH_ProtMapperProtMapperProtMapper:24710148ProtMapper:30591653
IL6STJAK2O60674Y683phosphorylationKEAKEA:10661409
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Ligand-Receptor Signaling

78 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cytokinereceptorAlmen2009NoYesYesYesNo
receptorreceptorSignaLink_functionNoYesYesYesNo
ig_likereceptorAlmen2009NoYesYesYesNo
type1_ig_like_cytokinereceptorAlmen2009NoYesYesYesNo
cytokine_receptorreceptorCellPhoneDBNoYesYesYesNo
interleukinreceptorBaccin2019NoYesYesYesNo
cytokinereceptorBaccin2019NoYesYesYesNo
cytokine_type_1receptorHPMRNoYesYesYesNo
osmr_cytokine_type_1receptorHPMRNoYesYesYesNo
igreceptorSurfaceomeNoYesYesYesNo
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Regulatory Interaction Network

19 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
IL6P05231IL6RBP40189YesYesNoiTALKSIGNORHINTInnateDBDIPUniProt_LRdbLit-BM-17HPMR_talklrHPMRHPRD_LRdbtalklrscConnectHPRDWojtowicz2020Ramilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbNetPathconnectomeDB2020SPIKE_LCLRdbSPIKEBaccin2019:3136546HINT:8702737HPRD:14557255SPIKE_LC:17145710DIP:7744001SPIKE_LC:15895091Baccin2019:8293462scConnect:1995637HINT:36930708connectomeDB2020:3136546InnateDB:15895091DIP:11251120HPMR:3136546SPIKE:19715447connectomeDB2020:14557255Guide2Pharma:1995637HINT:12829785Lit-BM-17:12829785CellTalkDB:14557255SIGNOR:15895091SPIKE:15895091Baccin2019:14557255NetPath:2788034connectomeDB2020:8293462LRdb:8293462LRdb:14557255LRdb:3136546SPIKE_LC:19715447HINT:18775332Lit-BM-17:11251120Lit-BM-17:18775332HPMR:15895091Lit-BM-17:7744001HINT:11251120
IL6RBP40189SHC1P29353YesYesNoWangNetPathSIGNORLi2012SPIKE_LCSPIKESPIKE_LC:7963520SIGNOR:9126968NetPath:7963520SPIKE:7963520
SOCS3O14543IL6RBP40189YesNoYesWangNetPathSIGNORProtMapperHPRDHINTSPIKE_LCREACH_ProtMapperSPIKESIGNOR:23454976HPRD:12403768ProtMapper:30591653HINT:24438103NetPath:10777583HPRD:10946280SPIKE:10777583SIGNOR:19620279SPIKE_LC:10777583HINT:10777583ProtMapper:34253862ProtMapper:24710148HINT:12403768
IL6RBP40189JAK2O60674YesYesNoWangKEGG-MEDICUSNetPathiPTMnetSIGNORProtMapperSignaLink3SIGNOR_ProtMapperSPIKESPIKE_LCSignaLink3:8174677SPIKE_LC:8174677ProtMapper:9716487SPIKE:8174677NetPath:7896787SIGNOR:9716487SignaLink3:23331499iPTMnet:9716487
OSMRQ99650IL6RBP40189YesYesNoHPRDWangSignaLink3SignaLink3:18988627SignaLink3:10692570SignaLink3:9188471SignaLink3:23331499SignaLink3:8999038SignaLink3:21071413HPRD:9188471
IL6RAP08887IL6RBP40189YesYesNoNetPathSIGNORHPRDHINTSignaLink3InnateDBWangHINT:11238858HINT:7744875InnateDB:7744875InnateDB:8706672InnateDB:9694899SIGNOR:11238858HINT:12829785SignaLink3:11238858HINT:2788034InnateDB:14656210HINT:36930708SignaLink3:23331499InnateDB:2788034NetPath:2788034HPRD:2788034SIGNOR:23663276HINT:9694899
LIFRP42702IL6RBP40189YesYesNoSIGNORHPRDSignaLink3BioGRIDWangBioGRID:12047380SignaLink3:16254248SIGNOR:24710148SignaLink3:8999038SignaLink3:23331499BioGRID:8999038HPRD:12047380SignaLink3:21071413
CTF1Q16619IL6RBP40189YesYesNoiTALKSIGNORSignaLink3HPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPRD_talklrBaccin2019EMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdbSIGNOR:9030543HPRD:11834704SignaLink3:9030543LRdb:11834704connectomeDB2020:11834704CellTalkDB:11834704SignaLink3:23331499Baccin2019:11834704
IL6RBP40189TYK2P29597YesYesNoDIPWangSignaLink3HPRDSignaLink3:10929036SignaLink3:9388212HPRD:9388212SignaLink3:23331499DIP:9388212
IL6RBP40189JAK1P23458YesYesNoNetPathSIGNORHPRDHINTSignaLink3BioGRIDDIPWangBioGRID:11742534HPRD:11742534SignaLink3:12487370SIGNOR:24710148SIGNOR:23663276SignaLink3:11468294HINT:9388212SignaLink3:11742534NetPath:7896787HINT:11468294DIP:21220115HPRD:11468294DIP:9388212SignaLink3:23331499HINT:21220115
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Protein Complex Composition

17 records.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
IL6RIL6STP08887P401890:0Guide2PharmaCellChatDBKEGG-MEDICUSICELLNETCellinkerSPIKE91437071995637
IL6STOSMP13725P401890:0hu.MAPhu.MAP2
IL6STLIFROSMP13725P40189P427021:1:1PDBPDB:8v29PDB:8v2a
C5orf22IL6STOSMTRPM3P13725P40189Q49AR2Q9HCF60:0:0:0hu.MAP2
IL6STOSMTRPM3P13725P40189Q9HCF60:0:0hu.MAPhu.MAP2
IL6STLIFP15018P401892:2PDBPDB:1pvh
IL6STP401892PDBPDB:1bquPDB:3l5jPDB:8upa
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Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationSize Exclusion ChromatographyMass spectrometryR Sequencing112973033
Sequence, Structure & Domains

Sequences

Length
918
Mass
103,537
Sequence
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40189-1; Sequence=Displayed; Name=2; Synonyms=GP130-RAPS; IsoId=P40189-2; Sequence=VSP_001684, VSP_001685; Name=3; IsoId=P40189-3; Sequence=VSP_043716
Alternative Sequence
325..329; RPSKA -> NIASF (in isoform 2); 330..918; Missing (in isoform 2); 423..483; Missing (in isoform 3)

3D Structural Models

Turn
108..110
Helix
52..58; 62..64; 76..78; 216..218; 248..251; 274..277; 325..331; 356..359; 544..547
Beta Strand
28..35; 37..39; 44..50; 65..69; 80..83; 86..91; 97..107; 111..123; 130..137; 143..147; 157..164; 165..168; 176..178; 181..183; 190..192; 194..202; 205..208; 212..214; 219..221; 226..231; 234..238; 240..245; 255..263; 282..286; 291..303; 306..308; 317..321; 332..338; 345..351; 363..372; 373..375; 378..391; 396..406; 412..416; 428..435; 438..444; 452..460; 462..464; 469..474; 478..481; 491..500; 508..515; 525..530; 531..533; 535..539; 553..560; 566..571; 575..579; 587..596; 599..602; 606..609
3D Structure
Electron microscopy (10); NMR spectroscopy (1); X-ray crystallography (9)

Domain & Motif Annotations

Compositional Bias
731..755; Low complexity
Motif
310..314; WSXWS motif; 651..659; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
Domain (FT)
26..120; Ig-like C2-type; 125..216; Fibronectin type-III 1; 224..324; Fibronectin type-III 2; 329..424; Fibronectin type-III 3; 426..517; Fibronectin type-III 4; 518..613; Fibronectin type-III 5
Region
660..681; Disordered; 722..758; Disordered
Protein Families
  • Type I cytokine receptor family
  • Type 2 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Drugs
BAZEDOXIFENESATRALIZUMABNULLRALOXIFENE HYDROCHLORIDE
Antibody
HPA010558CAB025784