Protein detail
IL6RB
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Entry name IL6RB | UniProt ID | EVMP score 0.50 |
Frequency 1 | Transmembrane count 1 | Protein classification Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Protein Class
Cancer-related genesCandidate cardiovascular disease genesCD markersDisease related genesHuman disease related genesPlasma proteinsPredicted membrane proteinsPredicted secreted proteins
Protein Function
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- CD markers
- Candidate cardiovascular disease genes
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Transmembrane
620..641; Helical
Transmembrane Count
1
Ensembl
Entrez Gene Symbol
Gene Synonym
CD130GP130IL-6RBsGP130
Gene Description
Interleukin 6 cytokine family signal transducer
Chromosome
5
Position
55935095-55995022
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificBreast hormone-responsive cellsSingle-Nuclei Brain Specificeccentric medium spiny neuron
Function & Pathway
Protein Function
- Human disease related genes:Congenital malformations:Congenital malformations of the musculoskeletal system
- CD markers
- Candidate cardiovascular disease genes
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Cellular Component
- GO:0005576 extracellular region
- GO:0005615 extracellular space
- GO:0005886 plasma membrane
- GO:0005896 interleukin-6 receptor complex
- GO:0005900 oncostatin-M receptor complex
- GO:0009897 external side of plasma membrane
- GO:0016020 membrane
- GO:0030425 dendrite
- GO:0043025 neuronal cell body
- GO:0043235 receptor complex
- GO:0045121 membrane raft
- GO:0070062 extracellular exosome
- GO:0070110 ciliary neurotrophic factor receptor complex
Molecular Function
- GO:0004896 cytokine receptor activity
- GO:0004897 ciliary neurotrophic factor receptor activity
- GO:0004915 interleukin-6 receptor activity
- GO:0004921 interleukin-11 receptor activity
- GO:0004923 leukemia inhibitory factor receptor activity
- GO:0004924 oncostatin-M receptor activity
- GO:0005127 ciliary neurotrophic factor receptor binding
- GO:0005138 interleukin-6 receptor binding
- GO:0005515 protein binding
- GO:0015026 coreceptor activity
- GO:0019838 growth factor binding
- GO:0019955 cytokine binding
- GO:0019970 interleukin-11 binding
- GO:0019981 interleukin-6 binding
- GO:0030296 protein tyrosine kinase activator activity
- GO:0042802 identical protein binding
- GO:0045509 interleukin-27 receptor activity
- GO:0097110 scaffold protein binding
Biological Process
KEGG
- hsa04060 Cytokine-cytokine receptor interaction
- KEGG:hsa04061 Viral protein interaction with cytokine and cytokine receptor
- KEGG:hsa04550 Signaling pathways regulating pluripotency of stem cells
- KEGG:hsa04630 JAK-STAT signaling pathway
- KEGG:hsa04659 Th17 cell differentiation
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05200 Pathways in cancer
- KEGG:hsa05203 Viral carcinogenesis
Reactome
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-6788467 il 6 type cytokine receptor ligand interactions
- R-hsa-447115 interleukin 12 family signaling
- R-hsa-9020956 interleukin 27 signaling
- R-hsa-8984722 interleukin 35 signalling
- R-hsa-6783589 interleukin 6 family signaling
- R-hsa-1059683 interleukin 6 signaling
- R-hsa-112411 mapk1 erk2 activation
- R-hsa-5684996 mapk1 mapk3 signaling
- R-hsa-110056 mapk3 erk1 activation
- R-hsa-5683057 mapk family signaling cascades
- R-hsa-112409 raf independent mapk1 3 activation
- R-hsa-449147 signaling by interleukins
Mediation Categories
Adhesion and uptake mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
18 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| IL6ST | CAMK2A | Q9UQM7 | S | 782 | phosphorylation | PhosphoSite | |
| IL6ST | CAMK2A | Q9UQM7 | S | 780 | phosphorylation | KEA | KEA:16036214 |
| IL6ST | EGF | P01133 | S | 667 | phosphorylation | BEL-Large-Corpus_ProtMapperProtMapper | ProtMapper:17081983 |
| IL6ST | MAPKAPK2 | P49137 | S | 782 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:20200229 |
| IL6ST | LIF | P15018 | S | 782 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:10811661 |
| IL6ST | CAMK2G | Q13555 | S | 782 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:22306348 |
| IL6ST | SOCS3 | O14543 | Y | 759 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:24710148ProtMapper:30591653 |
| IL6ST | JAK2 | O60674 | Y | 683 | phosphorylation | KEA | KEA:10661409 |
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Ligand-Receptor Signaling
78 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | CellPhoneDB | No | Yes | Yes | Yes | No |
| receptor | receptor | GO_Intercell | No | Yes | Yes | Yes | No |
| receptor | receptor | HPMR | No | Yes | Yes | Yes | No |
| receptor | receptor | ICELLNET | No | Yes | Yes | Yes | No |
| receptor | receptor | CellTalkDB | No | Yes | Yes | Yes | No |
| receptor | receptor | Surfaceome | No | Yes | Yes | Yes | No |
| receptor | receptor | Ramilowski2015 | No | Yes | Yes | Yes | No |
| receptor | receptor | Guide2Pharma | No | Yes | Yes | Yes | No |
| receptor | receptor | LRdb | No | Yes | Yes | Yes | No |
| receptor | receptor | Baccin2019 | No | Yes | Yes | Yes | No |
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Regulatory Interaction Network
19 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| IL6RB | P40189 | GAB2 | Q9UQC2 | Yes | Yes | No | WangSignaLink3 | SignaLink3:10068651SignaLink3:23331499 |
| LIF | P15018 | IL6RB | P40189 | Yes | Yes | No | iTALKSIGNORProtMapperHINTLit-BM-17HPMR_talklrDOMINOHPMRHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019REACH_ProtMapperSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbSparser_ProtMapperconnectomeDB2020SPIKE_LCLRdb | ProtMapper:10811661LRdb:127Baccin2019:971648712707269HPMR:9716487SPIKE_LC:17145710IntAct:16051226connectomeDB2020:9716487CellTalkDB:9716487Lit-BM-17:14527405HINT:36930708LRdb:9716487HINT:16051226SPIKE_LC:16051226DOMINO:16051226HINT:14527405IntAct:14527405SIGNOR:9143707ProtMapper:16036214HPRD:12707269Lit-BM-17:16051226connectomeDB2020:12707269 |
| KPCD | Q05655 | IL6RB | P40189 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteNetPathHPRD-phos | HPRD-phos:12361954ProtMapper:12361954HPRD:12361954NetPath:12361954SIGNOR:12361954PhosphoSite:12361954phosphoELM:12361954KEA:12361954 |
| IL6RB | P40189 | YES | P07947 | Yes | Yes | No | SIGNOR | SIGNOR:31296870 |
| IL11 | P20809 | IL6RB | P40189 | Yes | Yes | No | iTALKSIGNORHINTInnateDBDIPHPMR_talklrHPMRtalklrscConnectRamilowski2015_Baccin2019DLRP_talklrWangRamilowski2015HPMR_LRdbBaccin2019EMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020LRdb | LRdb:10948192connectomeDB2020:10948192CellTalkDB:10948192DIP:8360477SIGNOR:28232471HINT:9560294SIGNOR:9143707Baccin2019:10948192HPMR:10948192InnateDB:9560294HINT:37985757 |
| CNTF | P26441 | IL6RB | P40189 | Yes | Yes | No | iTALKSIGNORHINTLit-BM-17DOMINOHPMRHPRD_LRdbDLRP_CellinkertalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPRD_talklrBaccin2019CellinkerSTRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb | connectomeDB2020:16051226Baccin2019:16051226IntAct:16051226HPRD:12643274Baccin2019:12643274HINT:36930708HPRD:16051226HINT:16051226SPIKE_LC:16051226DOMINO:16051226Cellinker:12643274Cellinker:16051226connectomeDB2020:12643274SIGNOR:9143707LRdb:12643274LRdb:16HINT:18775332Lit-BM-17:16051226HPMR:10966616Lit-BM-17:18775332 |
| ONCM | P13725 | IL6RB | P40189 | Yes | Yes | No | iTALKSIGNORHINTUniProt_LRdbDIPHPMR_talklrDOMINOHPMRHPRD_LRdbtalklrscConnectHPRDIntActDLRP_talklrRamilowski2015_Baccin2019WangRamilowski2015HPMR_LRdbHPRD_talklrBaccin2019STRING_talklrEMBRACECellCallGuide2PharmaCellTalkDBFantom5_LRdbconnectomeDB2020SPIKE_LCLRdb | connectomeDB2020:16051226CellTalkDB:16051226Baccin2019:16051226HPRD:8999038IntAct:16051226connectomeDB2020:10854424HINT:8999038Baccin2019:8999038HPMR:8999038HPRD:16051226HINT:16051226LRdb:10854424SPIKE_LC:16051226DOMINO:16051226HPMR:10854424SIGNOR:9143707LRdb:8999038HINT:33961781LRdb:16051226DIP:8999038Baccin2019:10854424connectomeDB2020:8999038 |
| CLCF1 | Q9UBD9 | IL6RB | P40189 | Yes | Yes | No | Guide2PharmaHPMRFantom5_LRdbCellTalkDBHPMR_LRdbiTALKtalklrRamilowski2015SIGNORconnectomeDB2020HINTBaccin2019Ramilowski2015_Baccin2019WangLRdbEMBRACEHPMR_talklr | connectomeDB2020:10966616LRdb:10966616HPMR:10966616Baccin2019:10966616CellTalkDB:10966616HINT:36930708SIGNOR:9143707 |
| KCC2A | Q9UQM7 | IL6RB | P40189 | Yes | No | No | ProtMapperphosphoELM_KEAKEAPhosphoSitePhosphoSite_ProtMapper | PhosphoSite:10811661KEA:16036214 |
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Protein Complex Composition
17 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| IL6RIL6ST | P08887P40189 | 0:0 | Guide2PharmaCellChatDBKEGG-MEDICUSICELLNETCellinkerSPIKE | 91437071995637 | ||
| IL6STOSM | P13725P40189 | 0:0 | hu.MAPhu.MAP2 | |||
| IL6STLIFROSM | P13725P40189P42702 | 1:1:1 | PDB | PDB:8v29PDB:8v2a | ||
| C5orf22IL6STOSMTRPM3 | P13725P40189Q49AR2Q9HCF6 | 0:0:0:0 | hu.MAP2 | |||
| IL6STOSMTRPM3 | P13725P40189Q9HCF6 | 0:0:0 | hu.MAPhu.MAP2 | |||
| IL6STLIF | P15018P40189 | 2:2 | PDB | PDB:1pvh | ||
| IL6ST | P40189 | 2 | PDB | PDB:1bquPDB:3l5jPDB:8upa |
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometryR Sequencing | 1 | 12973033 |
Sequence, Structure & Domains
Sequences
Length
918
Mass
103,537
Sequence
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHVNANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACDFQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGGKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKINTEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRSESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSVNEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEGMPKSYLPQTVRQGGYMPQ
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P40189-1; Sequence=Displayed; Name=2; Synonyms=GP130-RAPS; IsoId=P40189-2; Sequence=VSP_001684, VSP_001685; Name=3; IsoId=P40189-3; Sequence=VSP_043716
Alternative Sequence
325..329; RPSKA -> NIASF (in isoform 2); 330..918; Missing (in isoform 2); 423..483; Missing (in isoform 3)
3D Structural Models
Turn
108..110
Helix
52..58; 62..64; 76..78; 216..218; 248..251; 274..277; 325..331; 356..359; 544..547
Beta Strand
28..35; 37..39; 44..50; 65..69; 80..83; 86..91; 97..107; 111..123; 130..137; 143..147; 157..164; 165..168; 176..178; 181..183; 190..192; 194..202; 205..208; 212..214; 219..221; 226..231; 234..238; 240..245; 255..263; 282..286; 291..303; 306..308; 317..321; 332..338; 345..351; 363..372; 373..375; 378..391; 396..406; 412..416; 428..435; 438..444; 452..460; 462..464; 469..474; 478..481; 491..500; 508..515; 525..530; 531..533; 535..539; 553..560; 566..571; 575..579; 587..596; 599..602; 606..609
3D Structure
Electron microscopy (10); NMR spectroscopy (1); X-ray crystallography (9)
Domain & Motif Annotations
Compositional Bias
731..755; Low complexity
Motif
310..314; WSXWS motif; 651..659; Box 1 motif
Domain (CC)
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.; DOMAIN: The box 1 motif is required for JAK interaction and/or activation.
Domain (FT)
26..120; Ig-like C2-type; 125..216; Fibronectin type-III 1; 224..324; Fibronectin type-III 2; 329..424; Fibronectin type-III 3; 426..517; Fibronectin type-III 4; 518..613; Fibronectin type-III 5
Region
660..681; Disordered; 722..758; Disordered
Protein Families
- Type I cytokine receptor family
- Type 2 subfamily
Sequence Similarities
Belongs to the type I cytokine receptor family. Type 2 subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant