Protein detail

CD79B

B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)

Protein symbol
CD79B
UniProt ID
P40259
EVMP score
0.50
Frequency
1
Transmembrane count
1
Protein classification
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteins
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
B-cell antigen receptor complex-associated protein beta chain (B-cell-specific glycoprotein B29) (Ig-beta) (Immunoglobulin-associated B29 protein) (CD antigen CD79b)
Protein Class
Cancer-related genesCD markersDisease related genesFDA approved drug targetsHuman disease related genesPredicted membrane proteins
Protein Function
  • Cancer-related genes:Mutated cancer genes
  • CD markers
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
  • Disease related genes
  • FDA approved drug targets:Biotech drugs
Transmembrane
160..180; Helical
Transmembrane Count
1
Ensembl
ENSG00000007312
Entrez Gene Symbol
CD79B
Gene Synonym
B29Ig-betaIGBIgbeta
Gene Description
CD79b molecule
Chromosome
17
Position
63928738-63932336
Frequency
1
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
  • Cancer-related genes:Mutated cancer genes
  • CD markers
  • Human disease related genes:Immune system diseases:Primary immunodeficiency
  • Human disease related genes:Cancers:Cancers of haematopoietic and lymphoid tissues
  • Disease related genes
  • FDA approved drug targets:Biotech drugs
Cellular Component
Molecular Function
Biological Process
KEGG
hsa04662 B cell receptor signaling pathway
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediation
Relations & Evidence

Enzyme-Mediated Modification

26 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
CD79BLCKP06239Y207phosphorylationKEAKEA:8077654KEA:9531288
CD79BLCKP06239Y92phosphorylationKEAKEA:8077654KEA:9531288
CD79BBLKP51451Y207phosphorylationReactome_ProtMapperProtMapper
CD79BBLKP51451Y196phosphorylationReactome_ProtMapperProtMapper
CD79BSRMSQ9H3Y6Y207phosphorylationReactome_ProtMapperProtMapper
CD79BSRMSQ9H3Y6Y196phosphorylationReactome_ProtMapperProtMapper
Page 3 of 3Previous

Ligand-Receptor Signaling

29 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
transmembranetransmembraneUniProt_locationNoNoNoYesNo
transmembranetransmembraneUniProt_topologyNoNoNoYesNo
transmembranetransmembraneUniProt_keywordNoNoNoYesNo
transmembranetransmembraneGO_IntercellNoNoNoYesNo
transmembranetransmembraneTopDBNoNoNoYesNo
transmembranetransmembraneLOCATENoNoNoYesNo
transmembranetransmembraneRamilowski_locationNoNoNoYesNo
transmembranetransmembraneOmniPathNoNoNoYesNo
plasma_membraneplasma_membraneUniProt_locationNoNoNoYesNo
plasma_membraneplasma_membraneCellinkerNoNoNoYesNo
Page 2 of 3PreviousNext

Regulatory Interaction Network

3 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
LYNP07948CD79BP40259YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangNetworKIN_KEAHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperReactome_ProtMapperSPIKE_LCSPIKESPIKE_LC:12453414SPIKE:12453414KEA:8077654HPRD:9531288phosphoELM:9531288ProtMapper:9531288SIGNOR:9531288KEA:9531288KEA:17570479HPRD-phos:9531288
FYNP06241CD79BP40259YesYesNoHPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAPhosphoNetworksHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperReactome_ProtMapperHPRD-phosKEA:8077654HPRD:9531288phosphoELM:9531288ProtMapper:9531288SIGNOR:9531288KEA:9531288HPRD-phos:9531288
SH2B1Q9NRF2CD79BP40259YesNoYesSIGNORSIGNOR:32323266

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
CD79BP402592PDBPDB:3kg5

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Protein Organic Solvent PrecipitationMass spectrometry132384937
Sequence, Structure & Domains

Sequences

Length
229
Mass
26,048
Sequence
MARLALSPVPSHWMVALLLLLSAEPVPAARSEDRYRNPKGSACSRIWQSPRFIARKRGFTVKMHCYMNSASGNVSWLWKQEMDENPQQLKLEKGRMEESQNESLATLTIQGIRFEDNGIYFCQQKCNNTSEVYQGCGTELRVMGFSTLAQLKQRNTLKDGIIMIQTLLIILFIIVPIFLLLDKDDSKAGMEEDHTYEGLDIDQTATYEDIVTLRTGEVKWSVGEHPGQE
Alternative Products
Event=Alternative splicing; Named isoforms=3; Name=Long; IsoId=P40259-1; Sequence=Displayed; Name=Short; IsoId=P40259-2; Sequence=VSP_002477; Name=3; IsoId=P40259-3; Sequence=VSP_047222
Alternative Sequence
23; A -> AA (in isoform 3); 41..144; Missing (in isoform Short)

3D Structural Models

Turn
93..95
Helix
114..116; 151..181
Beta Strand
46..49; 51..56; 60..66; 69..72; 74..79; 96..100; 105..111; 118..125; 127..129; 132..134; 138..140
3D Structure
Electron microscopy (4); X-ray crystallography (1)

Domain & Motif Annotations

Domain (CC)
The transmembrane helices of CD79A and CD79B chains and two IgM heavy chains assembly in a four-helix bundle structure that appears to be conserved among different BCR isotypes.
Domain (FT)
38..138; Ig-like V-type; 185..213; ITAM
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases
Autoimmune diseaseDiffuse large B-cell lymphomaFollicular lymphomaMalignant haematopoietic neoplasmMature B-cell lymphoma
Biomarker
Phase 1; Approved; Phase 2
Drug Targets
FDA approved drug targets
Drugs
POLATUZUMAB VEDOTINMGD-010DIOA
Antibody
HPA009178CAB009751HPA044107