Protein detail
ADH7
All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase)
Protein symbol ADH7 | UniProt ID | EVMP score 0.38 |
Frequency 1 | Transmembrane count | Protein classification EnzymesMetabolic proteinsPredicted intracellular proteins |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase)
Protein Class
EnzymesMetabolic proteinsPredicted intracellular proteins
Protein Function
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Gene Synonym
ADH-4
Gene Description
Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Chromosome
4
Position
99412261-99435510
Frequency
1
EVMP Score
0.38
Fluorescence & Localization
Tissue SpecifictestisCell SpecificCone photoreceptor cells
Function & Pathway
Protein Function
- Enzymes
- ENZYME proteins:Oxidoreductases
- Predicted intracellular proteins
Cellular Component
Molecular Function
- GO:0004022 alcohol dehydrogenase (NAD+) activity
- GO:0004031 aldehyde oxidase activity
- GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
- GO:0008270 zinc ion binding
- GO:0019841 retinol binding
- GO:0035276 ethanol binding
- GO:0048019 receptor antagonist activity
- GO:0050153 omega-hydroxydecanoate dehydrogenase activity
Biological Process
KEGG
- hsa00010 Glycolysis / Gluconeogenesis
- KEGG:hsa00071 Fatty acid degradation
- KEGG:hsa00350 Tyrosine metabolism
- KEGG:hsa00620 Pyruvate metabolism
- KEGG:hsa00830 Retinol metabolism
- KEGG:hsa00980 Metabolism of xenobiotics by cytochrome P450
- KEGG:hsa00982 Drug metabolism - cytochrome P450
- KEGG:hsa01100 Metabolic pathways
- KEGG:hsa04936 Alcoholic liver disease
Reactome
Canonical Pathways
- M156 Pid ecadherin nascent aj pathway
- M81 Pid cdc42 pathway
Mediation Categories
Metabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
0 records.
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
386
Mass
41,481
Sequence
MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P40394-1; Sequence=Displayed; Name=2; IsoId=P40394-2; Sequence=VSP_043093
Alternative Sequence
1..18; MFAEIQIQDKDRMGTAGK -> MKCLVSRHTVRETLDMVFQRMSVEAG (in isoform 2)
3D Structural Models
Turn
153..155; 296..298; 348..350
Helix
60..67; 114..117; 166..168; 178..181; 182..185; 187..196; 214..225; 238..240; 241..247; 255..257; 262..270; 284..291; 318..321; 331..333; 336..347; 355..357; 364..366; 367..375
Beta Strand
20..29; 35..41; 48..57; 68..70; 74..76; 81..89; 101..104; 111..113; 142..150; 158..165; 169..171; 206..210; 229..234; 250..253; 276..279; 300..303; 313..315; 325..328; 358..363; 380..385
3D Structure
X-ray crystallography (3)
Domain & Motif Annotations
Protein Families
- Zinc-containing alcohol dehydrogenase family
- Class-IV subfamily
Sequence Similarities
Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily.
Clinical Relevance
Antibody