Protein detail

OPRK

Kappa-type opioid receptor (K-OR-1) (KOR-1)

Protein symbol OPRK	UniProt ID P41145	EVMP score 0.50
Frequency 2	Transmembrane count 7	Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Kappa-type opioid receptor (K-OR-1) (KOR-1)

Protein Class

FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters

Protein Function

Transporters
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

58..85; Helical; Name=1; 96..119; Helical; Name=2; 133..154; Helical; Name=3; 174..196; Helical; Name=4; 223..247; Helical; Name=5; 275..296; Helical; Name=6; 312..333; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000082556

Entrez Gene Symbol

OPRK1

Gene Synonym

KOROPRK

Gene Description

Opioid receptor kappa 1

Chromosome

Position

53225724-53251637

Frequency

EVMP Score

0.50

Fluorescence & Localization

Tissue SpecifictestisCell SpecificDifferentiating spermatogonia

Function & Pathway

Protein Function

Transporters
FDA approved drug targets:Small molecule drugs
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
OPRK1	GRK1	Q15835	S	358	phosphorylation	PhosphoSitePhosphoSite_ProtMapperProtMapper

Ligand-Receptor Signaling

57 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	UniProt_keyword	No	No	No	Yes	No
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	LOCATE	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No

Page 4 of 6Previous Next

Regulatory Interaction Network

8 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PDYN	P01213	OPRK	P41145	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrCellChatDBtalklrscConnectWangGuide2Pharma_CellinkerRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrCellinkerSTRING_talklrGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	LRdb:1967312 LRdb:7624359 LRdb:7869844 connectomeDB2020:9262330 scConnect:9262330 LRdb:8170987 Cellinker:17503481 Guide2Pharma:7624359 connectomeDB2020:7624359 connectomeDB2020:9686407 scConnect:9686407 LRdb:9686407 Cellinker:9686407 scConnect:7624359 Cellinker:1967312 scConnect:1967312 Guide2Pharma:1967312 SIGNOR:9262330 CellTalkDB:7869844 connectomeDB2020:8170987 connectomeDB2020:7869844 Guide2Pharma:9262330 SIGNOR:9686407 Cellinker:9262330 Guide2Pharma:7869844 HINT:36638794 HINT:37285260 LRdb:9262330 connectomeDB2020:1967312 Cellinker:7624359 scConnect:7869844 Cellinker:7869844 Guide2Pharma:9686407 Cellinker:8170987
COLI	P01189	OPRK	P41145	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHPMR_talklrHPMRCellChatDBtalklrscConnectRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbGuide2Pharma_talklrBaccin2019CellinkerSTRING_talklrEMBRACEGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	HPMR:8624732 Cellinker:8624732 LRdb:7624359 Guide2Pharma:7624359 scConnect:9686407 connectomeDB2020:7624359 connectomeDB2020:9686407 LRdb:9686407 Cellinker:9686407 scConnect:7624359 Baccin2019:7624359 CellTalkDB:8624732 Baccin2019:8624732 SIGNOR:9686407 Baccin2019:9686407 Cellinker:7624359 Guide2Pharma:9686407 LRdb:8624732 connectomeDB2020:8624732
OPRK	P41145	GNAO	P09471	Yes	Yes	No	SIGNORCui2007HINTCA1Wang	CA1:15082510 HINT:37138078 SIGNOR:31160049
OPRK	P41145	GNAI3	P08754	Yes	Yes	No	WangCui2007SIGNORCA1	CA1:15082510 SIGNOR:31160049
OPRK	P41145	GNAI1	P63096	Yes	Yes	No	HINTSIGNOR	HINT:36638794 HINT:37138078 SIGNOR:31160049 HINT:37285260 HINT:38052802
MECP2	P51608	OPRK	P41145	Yes	Yes	No	SIGNOR	SIGNOR:18511691
OPRK	P41145	GNAZ	P19086	Yes	Yes	No	HINTSIGNOR	HINT:37138078 SIGNOR:31160049
GRK1	Q15835	OPRK	P41145	Yes	No	No	iPTMnetPhosphoSitePhosphoSite_ProtMapperProtMapper	PhosphoSite:18212250 PhosphoSite:23086943

Protein Complex Composition

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	OPRK1	P41145	2	PDB	PDB:4djhPDB:9mqkPDB:6vi4PDB:6b73

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometrySmall R sequencing (Illumi HiSeq 2000 (Solexa)	4	37576973 38343172 36114323 40595564

Sequence, Structure & Domains

Sequences

Length

380

Mass

42,645

Sequence

MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV

Alternative Products

Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P41145-1; Sequence=Displayed; Name=2; IsoId=P41145-2; Sequence=VSP_055313

Alternative Sequence

1..89; Missing (in isoform 2)

3D Structural Models

Turn

167..169; 257..259; 297..299; 331..333; 335..338

Helix

61..86; 93..109; 112..120; 128..161; 163..166; 172..194; 222..234; 246..253; 263..277; 307..330

Beta Strand

90..92; 121..123; 199..201; 203..206; 208..210; 216..218; 260..262; 300..302

3D Structure

Electron microscopy (21); X-ray crystallography (4)

Domain & Motif Annotations

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Disease Involvement

FDA approved drug targets

Related Diseases

Bipolar disorder Chronic pain Coronary vasospastic disease Depression Indeterminate colitis Irritable bowel syndrome Neurodegenerative disorder Non-specific cutaneous vascular sympton Obesity Opioid use disorder Pain Prurigo Pruritus Substance abuse Unspecific substance use disorder

Biomarker

Phase 1; Phase 2; Phase 3; Terminated; Approved; Preclinical; Phase 2/3; Discontinued in Phase 1

Drug Targets

FDA approved drug targets

Drugs

NALTREXONE HYDROCHLORIDE CODEINE ANHYDROUS MEPERIDINE HYDROCHLORIDE NULL CODEINE PHOSPHATE PAREGORIC SUFENTANIL OXYCODONE ODELEPRAN TRAMADOL PROPOXYPHENE PENTAZOCINE BUPRENORPHINE LEVALLORPHAN TARTRATE CHEMBL:CHEMBL2094567 DIFELIKEFALIN HYDROMORPHONE HYDROCHLORIDE SAMIDORPHAN L-MALATE CHEMBL:CHEMBL570176 CHEMBL:CHEMBL586135 NIRAVOLINE ENADOLINE CHEMBL:CHEMBL1492017 NALTREXONE CHEMBL:CHEMBL433508 CHEMBL:CHEMBL428064 NALOXONE HYDROCHLORIDE CLIOQUINOL CHEMBL:CHEMBL546170 NOR-BINALTORPHIMINE BENZHYDROCODONE HYDROCHLORIDE CHEMBL:CHEMBL1390716 NALMEFENE COCAINE AXOMADOL NALBUPHINE HYDROCHLORIDE U69593 BTRX-335140 CHLOROXINE SAMIDORPHAN ASIMADOLINE CR665 ORP-101 ATICAPRANT OXYMORPHONE 12-EPI-SALVINORIN A CHEMBL:CHEMBL300662 BUTORPHANOL SIROLIMUS CHEMBL:CHEMBL255067 DEZOCINE BUTORPHANOL TARTRATE CHEMBL:CHEMBL1941031 APADOLINE 5'-GUANIDINONALTRINDOLE CHEMBL:CHEMBL528694 CARFENTANIL HYDROCODONE POLISTIREX HYDROCODONE BITARTRATE NALFURAFINE HYDROCHLORIDE NALMEFENE HYDROCHLORIDE CEBRANOPADOL ANILERIDINE PHOSPHATE DEXTROMORAMIDE HYDROCODONE ANILERIDINE HYDROCHLORIDE U50488 SALVINORIN A METHYLSAMIDORPHAN CODEINE SULFATE

Antibody

HPA067549

Interaction Protein

ENSG00000139112

Interaction Count

Interaction Dataset

intact_biogrid