Protein detail
OPRK
Kappa-type opioid receptor (K-OR-1) (KOR-1)
Entry name OPRK | UniProt ID | EVMP confidence score 0.50 |
Supporting publications (n) 2 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information13
Protein Names
Kappa-type opioid receptor (K-OR-1) (KOR-1)
Protein Class (4)
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function (3)
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
58..85; Helical; Name=1; 96..119; Helical; Name=2; 133..154; Helical; Name=3; 174..196; Helical; Name=4; 223..247; Helical; Name=5; 275..296; Helical; Name=6; 312..333; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
KOROPRK
Gene Description
Opioid receptor kappa 1
Chromosome
8
Position
53225724-53251637
Supporting publications (n)
2
EVMP confidence score
0.50
Fluorescence & Localization2
Tissue SpecifictestisCell SpecificDifferentiating spermatogonia
Function & Pathway7
Protein Function (3)
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component (14)
- GO:0005654 nucleoplasm
- GO:0005739 mitochondrion
- GO:0005829 cytosol
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016529 sarcoplasmic reticulum
- GO:0030315 T-tubule
- GO:0030425 dendrite
- GO:0030672 synaptic vesicle membrane
- GO:0042734 presynaptic membrane
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Molecular Function (5)
Biological Process (3)
KEGG (3)
Reactome (8)
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-9022699 mecp2 regulates neuronal receptors and channels
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-372790 signaling by gpcr
- R-hsa-8986944 transcriptional regulation by mecp2
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence68
Enzyme-Mediated Modification (1)
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| OPRK1 | GRK1 | Q15835 | S | 358 | phosphorylation | PhosphoSitePhosphoSite_ProtMapperProtMapper |
Ligand-Receptor Signaling (57)
57 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | Almen2009 | No | Yes | No | Yes | No |
| receptor | receptor | CellCellInteractions | No | Yes | No | Yes | No |
| receptor | receptor | EMBRACE | No | Yes | No | Yes | No |
| gpcr | receptor | GPCRdb | No | Yes | No | Yes | No |
| opioid | receptor | HGNC | No | Yes | No | Yes | No |
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network (8)
8 records.
Protein Complex Composition (1)
Isolation & Detection Technology (1)
Sequence, Structure & Domains11
Sequences
Length
380
Mass
42,645
Sequence
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P41145-1; Sequence=Displayed; Name=2; IsoId=P41145-2; Sequence=VSP_055313
Alternative Sequence
1..89; Missing (in isoform 2)
3D Structural Models
Turn
167..169; 257..259; 297..299; 331..333; 335..338
Helix
61..86; 93..109; 112..120; 128..161; 163..166; 172..194; 222..234; 246..253; 263..277; 307..330
Beta Strand
90..92; 121..123; 199..201; 203..206; 208..210; 216..218; 260..262; 300..302
3D Structure
Electron microscopy (21); X-ray crystallography (4)
Domain & Motif Annotations
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance9
Disease Involvement
FDA approved drug targets
Related Diseases (15)
Biomarker
Phase 1; Phase 2; Phase 3; Terminated; Approved; Preclinical; Phase 2/3; Discontinued in Phase 1
Drug Targets
FDA approved drug targets
Drugs (70)
NALTREXONE HYDROCHLORIDECODEINE ANHYDROUSMEPERIDINE HYDROCHLORIDENULLCODEINE PHOSPHATEPAREGORICSUFENTANILOXYCODONEODELEPRANTRAMADOLPROPOXYPHENEPENTAZOCINEBUPRENORPHINELEVALLORPHAN TARTRATECHEMBL:CHEMBL2094567DIFELIKEFALINHYDROMORPHONE HYDROCHLORIDESAMIDORPHAN L-MALATECHEMBL:CHEMBL570176CHEMBL:CHEMBL586135NIRAVOLINEENADOLINECHEMBL:CHEMBL1492017NALTREXONECHEMBL:CHEMBL433508CHEMBL:CHEMBL428064NALOXONE HYDROCHLORIDECLIOQUINOLCHEMBL:CHEMBL546170NOR-BINALTORPHIMINEBENZHYDROCODONE HYDROCHLORIDECHEMBL:CHEMBL1390716NALMEFENECOCAINEAXOMADOLNALBUPHINE HYDROCHLORIDEU69593BTRX-335140CHLOROXINESAMIDORPHANASIMADOLINECR665ORP-101ATICAPRANTOXYMORPHONE12-EPI-SALVINORIN ACHEMBL:CHEMBL300662BUTORPHANOLSIROLIMUSCHEMBL:CHEMBL255067DEZOCINEBUTORPHANOL TARTRATECHEMBL:CHEMBL1941031APADOLINE5'-GUANIDINONALTRINDOLECHEMBL:CHEMBL528694CARFENTANILHYDROCODONE POLISTIREXHYDROCODONE BITARTRATENALFURAFINE HYDROCHLORIDENALMEFENE HYDROCHLORIDECEBRANOPADOLANILERIDINE PHOSPHATEDEXTROMORAMIDEHYDROCODONEANILERIDINE HYDROCHLORIDEU50488SALVINORIN AMETHYLSAMIDORPHANCODEINE SULFATE
Antibody
Interaction Protein
ENSG00000139112
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications2
| PMID | Title | Abstract |
|---|---|---|
| 38207106 | Proteomic, Metabolomic, and Fatty Acid Profiling of Small Extracellular Vesicles from Glioblastoma Stem-Like Cells and Their Role in Tumor Heterogeneity. | No abstract available |
| 40730843 | Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury. | No abstract available |