Protein detail
LEP
Leptin (Obese protein) (Obesity factor)
Entry name LEP | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) 1 | Transmembrane count | Protein classification Cancer-related genesCandidate cardiovascular disease genesDisease related genesHuman disease related genesPlasma proteinsPredicted secreted proteins |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information11
Protein Names
Leptin (Obese protein) (Obesity factor)
Protein Class (6)
Cancer-related genesCandidate cardiovascular disease genesDisease related genesHuman disease related genesPlasma proteinsPredicted secreted proteins
Protein Function (5)
- Candidate cardiovascular disease genes
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (2)
OBOBS
Gene Description
Leptin
Chromosome
7
Position
128241278-128257629
Supporting publications (n)
1
EVMP confidence score
0.38
Fluorescence & Localization5
Tissue SpecificpancreasCell SpecificPancreatic acinar cellsBlood Cell SpecificNK-cellBlood Lineage SpecificNK-cells
Function & Pathway7
Protein Function (5)
- Candidate cardiovascular disease genes
- Human disease related genes:Endocrine and metabolic diseases:Other endocrine and metabolic diseases
- Cancer-related genes:Candidate cancer biomarkers
- Predicted secreted proteins
- Disease related genes
Cellular Component (3)
Molecular Function (5)
Biological Process (3)
KEGG (7)
Reactome (7)
- R-hsa-9843745 adipogenesis
- R-hsa-400508 incretin synthesis secretion and inactivation
- R-hsa-2980736 peptide hormone metabolism
- R-hsa-2586552 signaling by leptin
- R-hsa-422085 synthesis secretion and deacylation of ghrelin
- R-hsa-381771 synthesis secretion and inactivation of glucagon like peptide 1 glp 1
- R-hsa-381340 transcriptional regulation of white adipocyte differentiation
Mediation Categories (5)
Adhesion and uptake mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence41
Ligand-Receptor Signaling (39)
39 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| secreted | secreted | Baccin2019 | No | No | Yes | No | No |
| secreted | secreted | Matrisome | No | No | Yes | No | No |
| secreted | secreted | Cellinker | No | No | Yes | No | No |
| secreted | secreted | OmniPath | No | No | Yes | No | No |
| ligand | ligand | talklr | Yes | No | Yes | No | No |
| ligand | ligand | Cellinker | Yes | No | Yes | No | No |
| ligand | ligand | scConnect | Yes | No | Yes | No | No |
| ligand | ligand | connectomeDB2020 | Yes | No | Yes | No | No |
| ligand | ligand | Matrisome | Yes | No | Yes | No | No |
| ligand | ligand | CellCall | Yes | No | Yes | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| LEP | P41159 | LEPR | P48357 | Yes | Yes | No | iTALKKirouac2010KEGG-MEDICUSGuide2Pharma_LRdbICELLNETSIGNORHINTSignaLink3DIPHPMR_talklrHPMRCellChatDBHPRD_LRdbDLRP_CellinkertalklrHPRDCui2007Wojtowicz2020Ramilowski2015_Baccin2019DLRP_talklrGuide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBaccin2019CellinkerSTRING_talklrCellCallCellTalkDBFantom5_LRdbHPMR_CellinkerNetPathconnectomeDB2020LRdb | HINT:22405007LRdb:861HPRD:8608603Baccin2019:8608603SIGNOR:9463481Cellinker:9463481Baccin2019:9463481NetPath:12226096CellTalkDB:9463481LRdb:9463481connectomeDB2020:8608603ICELLNET:9463481HPMR:9463481NetPath:9218470connectomeDB2020:9463481SignaLink3:23331499HINT:36959263Cellinker:8608603HINT:33961781DIP:9786864SignaLink3:9207021DIP:22405007 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass spectrometry | 1 | 38902710 |
Sequence, Structure & Domains8
Sequences
Length
167
Mass
18,641
Sequence
MHWGTLCGFLWLWPYLFYVQAVPIQKVQDDTKTLIKTIVTRINDISHTQSVSSKQKVTGLDFIPGLHPILTLSKMDQTLAVYQQILTSMPSRNVIQISNDLENLRDLLHVLAFSKSCHLPWASGLETLDSLGGVLEASGYSTEVVALSRLQGSLQDMLWQLDLSPGC
3D Structural Models
Turn
59..61
Helix
25..44; 72..87; 92..114; 128..131; 132..135; 142..160; 161..163
3D Structure
Electron microscopy (6); NMR spectroscopy (1); X-ray crystallography (2)
Domain & Motif Annotations
Protein Families
Leptin family
Sequence Similarities
Belongs to the leptin family.
Clinical Relevance3
Disease Involvement (4)
Cancer-related genesDiabetes mellitusDisease variantObesity
Drugs (24)
LAMIVUDINEESTRADIOL VALERATESOYBEAN SEED OILCLOZAPINEORAL CONTRACEPTIVEMETHADONE HYDROCHLORIDEPROPYLTHIOURACILMIRTAZAPINETROGLITAZONEANTICOAGULANT AGENTBROMOCRIPTINECYCLOSPORINENICOTINE POLACRILEXMETRELEPTINCARVEDILOLANHYDROUS TACROLIMUSMETHIMAZOLECALCIUM CHANNEL BLOCKERFOLIC ACIDLOVASTATINRISPERIDONEFELODIPINEGEMFIBROZILVALPROIC ACID
Supporting Publications1
| PMID | Title | Abstract |
|---|---|---|
| 38037300 | Proteomic profiling of paired human liver homogenate and tissue derived extracellular vesicles. | No abstract available |