Protein detail

AQP2

Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)

Protein symbol
AQP2
UniProt ID
P41181
EVMP score
0.38
Frequency
Transmembrane count
6
Protein classification
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Basic Information
Protein Names
Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
  • Disease related genes
  • Human disease related genes:Urinary system diseases:Kidney diseases
  • Transporters:Transporter channels and pores
  • Potential drug targets
Transmembrane
12..32; Helical; 41..59; Helical; 86..107; Helical; 128..148; Helical; 157..176; Helical; 202..222; Helical
Transmembrane Count
6
Ensembl
ENSG00000167580
Entrez Gene Symbol
AQP2
Gene Description
Aquaporin 2
Chromosome
12
Position
49950737-49958878
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificBasal keratinocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
  • Disease related genes
  • Human disease related genes:Urinary system diseases:Kidney diseases
  • Transporters:Transporter channels and pores
  • Potential drug targets
Cellular Component
Molecular Function
Biological Process
KEGG
hsa04962 Vasopressin-regulated water reabsorption
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence

Enzyme-Mediated Modification

22 records.

Substrate Gene SymbolEnzyme Gene SymbolEnzyme UniProt IDResidue TypeResidue OffsetModificationDatabaseReferences
AQP2CDK18Q07002S261phosphorylationSIGNORSIGNOR:32164329
AQP2PRKACAP17612S256phosphorylationphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperReactome_ProtMapperPhosphoSitePhosphoSite_ProtMapper
AQP2CSNK1A1P48729S256phosphorylationPhosphoSite
AQP2ROCK1Q13464T269phosphorylationPhosphoSite
AQP2PRKCAP17252S256phosphorylationPhosphoSite
AQP2PRKXP51817S256phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
AQP2PRKYO43930S256phosphorylationMIMPHPRD_MIMPphosphoELM_MIMPPhosphoSite_MIMP
AQP2PRKACBP22694S256phosphorylationReactome_ProtMapperProtMapper
AQP2PRKACGP22612S256phosphorylationReactome_ProtMapperSparser_ProtMapperProtMapperProtMapper:10392550
AQP2WNT5AP41221S256phosphorylationREACH_ProtMapperSparser_ProtMapperProtMapperProtMapper:27892464
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Ligand-Receptor Signaling

37 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
receptorreceptorOmniPathNoYesNoNoNo
extracellularextracellularOmniPathNoNoNoNoNo
intracellularintracellularLOCATENoNoNoNoNo
intracellularintracellularComPPINoNoNoNoNo
intracellularintracellularGO_IntercellNoNoNoNoNo
intracellularintracellularUniProt_locationNoNoNoNoNo
intracellularintracellularOmniPathNoNoNoNoNo
transportertransporterSurfaceomeNoYesNoNoNo
aquaporintransporterHGNCNoYesNoNoNo
transportertransporterHGNCNoYesNoNoNo
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Regulatory Interaction Network

2 records.

Source Protein SymbolSource UniProt IDTarget Protein SymbolTarget UniProt IDIs DirectedIs StimulationIs InhibitionDatabaseReferences
COMPLEX:P20248_Q07002AQP2P41181YesNoYesSIGNORSIGNOR:32164329
CDK18Q07002AQP2P41181YesNoYesSparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapperProtMapper:32164329SIGNOR:32164329

Protein Complex Composition

1 record.

Component NameComponent Gene SymbolsComponent UniProt IDStoichiometryDatabaseDatabase IDsReferences
AQP2P411814PDBPDB:4nefPDB:8vvxPDB:6qf5PDB:8oeePDB:8ghj

Isolation & Detection Technology

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass SpectrometryWestern BlottingImmunofluorescenceFlow Cytometry138588410
Sequence, Structure & Domains

Sequences

Length
271
Mass
28,837
Sequence
MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA

3D Structural Models

Turn
199..202
Helix
7..32; 41..63; 69..77; 83..107; 110..113; 127..148; 151..153; 159..179; 185..195; 203..221; 232..237
Beta Strand
35..37
3D Structure
Electron microscopy (2); X-ray crystallography (5)

Domain & Motif Annotations

Compositional Bias
261..271; Polar residues
Motif
68..70; NPA 1; 184..186; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Region
248..271; Disordered
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance
Disease Involvement
Diabetes insipidusDisease variant
Drugs
BIM 23268BIM 23313BIM 23056[125I]TYR3 SMS 201-995[125I]TYR10-CST14S5A1BOC-ATESRIF-14[111IN]DOTA-NOC[125I]LTT-SRIF-28L-363,301KE 108BIM 23050CORTISTATIN-14BIM 23197[111IN,90Y]DOTA-TOCBIM 23060[111IN,90Y]DOTA-LANNULLPRL-2915[111IN]DOTA-BOC-ATEOCTREOTIDE ACETATEBIM 23627[L-TYR8]CYN 154806[111IN]DOTA-NOC-ATESEGLITIDE[125I]CGP 23996VAPREOTIDECST-17DES-AA5-[D-TRP8]SRIFVELDOREOTIDE[111IN,90Y]DOTA-NOCCGP 23996LANREOTIDE ACETATESRIF-28BIM 23059BIM 23030PRL-2970[D-TYR8]CYN 154806L-362,855L-817,818[111IN,90Y]DOTA-OCPASIREOTIDEBIM 23052NOC-ATEBIM 23023[125I]TYR11-SRIF-14BIM 23454
Antibody
HPA046834
Interaction Protein
ENSG00000133935
Interaction Count
1
Interaction Dataset
intact_biogrid