Protein detail
AQP2
Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)
Protein symbol AQP2 | UniProt ID | EVMP score 0.38 |
Frequency | Transmembrane count 6 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP score: annotation confidence score.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40
Basic Information
Protein Names
Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)
Protein Class
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function
- Disease related genes
- Human disease related genes:Urinary system diseases:Kidney diseases
- Transporters:Transporter channels and pores
- Potential drug targets
Transmembrane
12..32; Helical; 41..59; Helical; 86..107; Helical; 128..148; Helical; 157..176; Helical; 202..222; Helical
Transmembrane Count
6
Ensembl
Entrez Gene Symbol
Gene Description
Aquaporin 2
Chromosome
12
Position
49950737-49958878
EVMP Score
0.38
Fluorescence & Localization
Tissue Specificskin 1Cell SpecificBasal keratinocytesBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- Disease related genes
- Human disease related genes:Urinary system diseases:Kidney diseases
- Transporters:Transporter channels and pores
- Potential drug targets
Cellular Component
- GO:0005794 Golgi apparatus
- GO:0005886 plasma membrane
- GO:0016020 membrane
- GO:0016323 basolateral plasma membrane
- GO:0016324 apical plasma membrane
- GO:0030658 transport vesicle membrane
- GO:0048471 perinuclear region of cytoplasm
- GO:0055037 recycling endosome
- GO:0070062 extracellular exosome
- GO:0098576 lumenal side of membrane
Molecular Function
Biological Process
Reactome
Mediation Categories
Fusion and delivery mediationMetabolism mediation
Relations & Evidence
Enzyme-Mediated Modification
22 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| AQP2 | WNT5A | P41221 | T | 269 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:27892464 |
| AQP2 | CD8A | P01732 | S | 256 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:17940053 |
| AQP2 | AVP | P01185 | S | 256 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:19570884ProtMapper:18431594ProtMapper:19144687ProtMapper:30488437ProtMapper:9950956 |
| AQP2 | AVP | P01185 | S | 261 | phosphorylation | Sparser_ProtMapperProtMapper | |
| AQP2 | AVP | P01185 | T | 269 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:29650969 |
| AQP2 | AVP | P01185 | S | 264 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:18287043 |
| AQP2 | DBI | P07108 | S | 256 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:26903868 |
| AQP2 | AKAP13 | Q12802 | S | 256 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:29650969 |
| AQP2 | AKAP13 | Q12802 | T | 269 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:29650969 |
| AQP2 | BIRC2 | Q13490 | T | 269 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:29650969 |
Ligand-Receptor Signaling
37 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| aquaporin | transporter | Almen2009 | No | Yes | No | No | No |
| channels | transporter | Surfaceome | No | Yes | No | No | No |
| aquaporins | transporter | Surfaceome | No | Yes | No | No | No |
| ion_channel | ion_channel | Almen2009 | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| ion_channel | ion_channel | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | OPM | No | No | No | No | No |
Regulatory Interaction Network
2 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P20248_Q07002 | AQP2 | P41181 | Yes | No | Yes | SIGNOR | SIGNOR:32164329 | |
| CDK18 | Q07002 | AQP2 | P41181 | Yes | No | Yes | Sparser_ProtMapperiPTMnetSIGNORProtMapperSIGNOR_ProtMapper | ProtMapper:32164329SIGNOR:32164329 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential Ultracentrifugation | Mass SpectrometryWestern BlottingImmunofluorescenceFlow Cytometry | 1 | 38588410 |
Sequence, Structure & Domains
Sequences
Length
271
Mass
28,837
Sequence
MWELRSIAFSRAVFAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLGIGTLVQALGHISGAHINPAVTVACLVGCHVSVLRAAFYVAAQLLGAVAGAALLHEITPADIRGDLAVNALSNSTTAGQAVTVELFLTLQLVLCIFASTDERRGENPGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAILGSLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGTKA
3D Structural Models
Turn
199..202
Helix
7..32; 41..63; 69..77; 83..107; 110..113; 127..148; 151..153; 159..179; 185..195; 203..221; 232..237
Beta Strand
35..37
3D Structure
Electron microscopy (2); X-ray crystallography (5)
Domain & Motif Annotations
Compositional Bias
261..271; Polar residues
Motif
68..70; NPA 1; 184..186; NPA 2
Domain (CC)
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Region
248..271; Disordered
Protein Families
MIP/aquaporin (TC 1.A.8) family
Sequence Similarities
Belongs to the MIP/aquaporin (TC 1.A.8) family.
Clinical Relevance
Disease Involvement
Diabetes insipidusDisease variant
Drugs
BIM 23268BIM 23313BIM 23056[125I]TYR3 SMS 201-995[125I]TYR10-CST14S5A1BOC-ATESRIF-14[111IN]DOTA-NOC[125I]LTT-SRIF-28L-363,301KE 108BIM 23050CORTISTATIN-14BIM 23197[111IN,90Y]DOTA-TOCBIM 23060[111IN,90Y]DOTA-LANNULLPRL-2915[111IN]DOTA-BOC-ATEOCTREOTIDE ACETATEBIM 23627[L-TYR8]CYN 154806[111IN]DOTA-NOC-ATESEGLITIDE[125I]CGP 23996VAPREOTIDECST-17DES-AA5-[D-TRP8]SRIFVELDOREOTIDE[111IN,90Y]DOTA-NOCCGP 23996LANREOTIDE ACETATESRIF-28BIM 23059BIM 23030PRL-2970[D-TYR8]CYN 154806L-362,855L-817,818[111IN,90Y]DOTA-OCPASIREOTIDEBIM 23052NOC-ATEBIM 23023[125I]TYR11-SRIF-14BIM 23454
Antibody
Interaction Protein
ENSG00000133935
Interaction Count
1
Interaction Dataset
intact_biogrid