Protein detail
5HT2B
5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)
Protein symbol 5HT2B | UniProt ID | EVMP score 0.25 |
Frequency 2 | Transmembrane count 7 | Protein classification FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)
Protein Class
FDA approved drug targetsG-protein coupled receptorsPredicted membrane proteinsTransporters
Protein Function
- G-protein coupled receptors:Serotonin receptors
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
57..79; Helical; Name=1; 91..113; Helical; Name=2; 130..151; Helical; Name=3; 172..192; Helical; Name=4; 217..239; Helical; Name=5; 325..345; Helical; Name=6; 361..382; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
5-HT(2B)5-HT2B
Gene Description
5-hydroxytryptamine receptor 2B
Chromosome
2
Position
231108230-231125042
Frequency
2
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificlymphoid tissueCell SpecificcDCSingle-Nuclei Brain Specificcentral nervous system macrophageBlood Cell SpecificbasophilBlood Lineage Specificgranulocytes
Function & Pathway
Protein Function
- G-protein coupled receptors:Serotonin receptors
- Transporters
- FDA approved drug targets:Small molecule drugs
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
- GO:0001587 Gq/11-coupled serotonin receptor activity
- GO:0001965 G-protein alpha-subunit binding
- GO:0004993 G protein-coupled serotonin receptor activity
- GO:0005096 GTPase activator activity
- GO:0005515 protein binding
- GO:0030594 neurotransmitter receptor activity
- GO:0051378 serotonin binding
- GO:0099589 serotonin receptor activity
Biological Process
KEGG
Reactome
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
0 records.
Ligand-Receptor Signaling
46 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
Regulatory Interaction Network
5 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| 5HT2B | P41595 | GNAI1 | P63096 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT2B | P41595 | GNAI3 | P08754 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT2B | P41595 | GNAQ | P50148 | Yes | Yes | No | HPRDWangSIGNOR | HPRD:11916537SIGNOR:31160049 |
| 5HT2B | P41595 | GNAZ | P19086 | Yes | Yes | No | SIGNOR | SIGNOR:31160049 |
| 5HT2B | P41595 | GNA14 | O95837 | Yes | Yes | No | WangSIGNOR | SIGNOR:31160049 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Mass spectrometry | 0 |
Sequence, Structure & Domains
Sequences
Length
481
Mass
54,298
Sequence
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
3D Structural Models
Turn
117..119; 395..397
Helix
40..49; 54..63; 65..81; 83..85; 88..106; 108..111; 113..116; 127..158; 160..163; 165..187; 189..193; 202..204; 211..225; 227..248; 281..284; 314..349; 355..381; 385..394
Beta Strand
198..201; 351..353
3D Structure
Electron microscopy (4); X-ray crystallography (8)
Domain & Motif Annotations
Motif
152..154; DRY motif; important for ligand-induced conformation changes; 212..215; [DE]RFG motif; may stabilize a conformation that preferentially activates signaling via beta-arrestin family members; 376..380; NPxxY motif; important for ligand-induced conformation changes and signaling; 479..481; PDZ-binding
Domain (CC)
Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
FDA approved drug targets
Related Diseases
Biomarker
Discontinued in Phase 3; Phase 4; Withdrawn from market; Approved; Investigative; Discontinued in Phase 1; Phase 2
Drug Targets
FDA approved drug targets
Drugs
CHLORPROTHIXENEPRX-08066AMISULPRIDECLOTHIAPINEMETHYSERGIDE MALEATEMINAPRINEDOXEPIN HYDROCHLORIDENULLZIMELDINE HYDROCHLORIDEMETHOTRIMEPRAZINETERGURIDEQUETIAPINE FUMARATEVABICASERINSUMATRIPTANTRIFLUPROMAZINEVABICASERIN HYDROCHLORIDEBF-1MINAPRINE HYDROCHLORIDEASENAPINEMETHYLERGONOVINE MALEATE3,4-METHYLENEDIOXYMETHAMPHETAMINEATC0175DEXFENFLURAMINE HYDROCHLORIDERENZAPRIDEAGOMELATINE