Protein detail
CCR2
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Protein symbol CCR2 | UniProt ID | EVMP score 0.50 |
Frequency 3 | Transmembrane count 7 | Protein classification CD markersG-protein coupled receptorsHuman disease related genesPredicted membrane proteins |
Basic Information
Protein Names
C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
Protein Class
CD markersG-protein coupled receptorsHuman disease related genesPredicted membrane proteins
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
43..70; Helical; Name=1; 81..100; Helical; Name=2; 115..136; Helical; Name=3; 154..178; Helical; Name=4; 207..226; Helical; Name=5; 244..268; Helical; Name=6; 286..309; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Gene Synonym
CC-CKR-2CD192CKR2CMKBR2FLJ78302MCP-1-R
Gene Description
C-C motif chemokine receptor 2
Chromosome
3
Position
46353864-46360940
Frequency
3
EVMP Score
0.50
Fluorescence & Localization
Function & Pathway
Protein Function
- G-protein coupled receptors:Chemokines and chemotactic factors receptors
- Human disease related genes:Immune system diseases:Allergies and autoimmune diseases
- CD markers
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
- GO:0004950 chemokine receptor activity
- GO:0005515 protein binding
- GO:0016493 C-C chemokine receptor activity
- GO:0019957 C-C chemokine binding
- GO:0031727 CCR2 chemokine receptor binding
- GO:0035715 chemokine (C-C motif) ligand 2 binding
- GO:0035716 chemokine (C-C motif) ligand 12 binding
- GO:0035717 chemokine (C-C motif) ligand 7 binding
- GO:0042802 identical protein binding
Biological Process
KEGG
Reactome
- R-hsa-6803157 antimicrobial peptides
- R-hsa-1461957 beta defensins
- R-hsa-380108 chemokine receptors bind chemokines
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-1461973 defensins
- R-hsa-500792 gpcr ligand binding
- R-hsa-418594 g alpha i signalling events
- R-hsa-168249 innate immune system
- R-hsa-6783783 interleukin 10 signaling
- R-hsa-375276 peptide ligand binding receptors
- R-hsa-372790 signaling by gpcr
- R-hsa-449147 signaling by interleukins
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| CCR2 | JAK2 | O60674 | Y | 139 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperRLIMS-P_ProtMapperKEAphosphoELMSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | SIGNOR:9670957KEA:9670957phosphoELM:9670957ProtMapper:9670957 |
Ligand-Receptor Signaling
61 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| class_a_rhodopsin_protein_chemokine | receptor | GPCRdb | No | Yes | No | Yes | No |
| chemokine | receptor | ICELLNET | No | Yes | No | Yes | No |
| chemokine_cc | receptor | ICELLNET | No | Yes | No | Yes | No |
| receptor | receptor | OmniPath | No | Yes | No | Yes | No |
| extracellular | extracellular | HPMR | No | No | No | Yes | No |
| extracellular | extracellular | DGIdb | No | No | No | Yes | No |
| extracellular | extracellular | OmniPath | No | No | No | Yes | No |
| intracellular | intracellular | ComPPI | No | No | No | Yes | No |
| intracellular | intracellular | GO_Intercell | No | No | No | Yes | No |
| intracellular | intracellular | OmniPath | No | No | No | Yes | No |
Regulatory Interaction Network
3 records.
Protein Complex Composition
Sequence, Structure & Domains
Sequences
Length
374
Mass
41,915
Sequence
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=A; IsoId=P41597-1; Sequence=Displayed; Name=B; IsoId=P41597-2; Sequence=VSP_001893
Alternative Sequence
314..374; SLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA -> RYLSVFFRKHITKRFCKQCPVFYRETVDGVTSTNTPSTGEQEVSAGL (in isoform B)
3D Structural Models
Turn
72..74; 266..268; 296..300
Helix
38..69; 76..92; 95..103; 110..142; 146..151; 154..170; 173..177; 196..210; 212..228; 237..265; 269..272; 279..295; 301..308; 310..318
Beta Strand
179..184; 187..192
3D Structure
Electron microscopy (1); NMR spectroscopy (2); X-ray crystallography (2)
Domain & Motif Annotations
Region
348..374; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Disease Involvement
Disease variant
Related Diseases
Alzheimer diseaseArterial occlusive diseaseChronic kidney diseaseChronic obstructive pulmonary diseaseChronic painGeneral pain disorderHuman immunodeficiency virus diseaseInsulin-resistance syndromeMelanomaMetastatic tumourMultiple sclerosisPancreatic cancerPostoperative inflammationRetinopathyRheumatoid arthritisSolid tumour/cancerViral encephalitis
Biomarker
Investigative; Terminated; Phase 2; Phase 1; Discontinued in Phase 2
Drugs