Protein detail
GRIA2
Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2)
Protein symbol GRIA2 | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 3 | Protein classification Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters |
Basic Information
Protein Names
Glutamate receptor 2 (GluR-2) (AMPA-selective glutamate receptor 2) (GluR-B) (GluR-K2) (Glutamate receptor ionotropic, AMPA 2)
Protein Class
Disease related genesHuman disease related genesPotential drug targetsPredicted intracellular proteinsPredicted membrane proteinsTransporters
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Transporters:Transporter channels and pores
- Disease related genes
Transmembrane
544..564; Helical; 617..637; Helical; 813..833; Helical; Name=M4
Transmembrane Count
3
Ensembl
Entrez Gene Symbol
Gene Synonym
GluA2GLUR2GLURB
Gene Description
Glutamate ionotropic receptor AMPA type subunit 2
Chromosome
4
Position
157204182-157387146
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Cell SpecificLymphatic endothelial cellsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- Potential drug targets
- Human disease related genes:Congenital malformations:Congenital malformations of the nervous system
- Transporters:Transporter channels and pores
- Disease related genes
Cellular Component
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0014069 postsynaptic density
- GO:0030425 dendrite
- GO:0030666 endocytic vesicle membrane
- GO:0032279 asymmetric synapse
- GO:0032281 AMPA glutamate receptor complex
- GO:0043025 neuronal cell body
- GO:0043197 dendritic spine
- GO:0060076 excitatory synapse
- GO:0098794 postsynapse
- GO:0098839 postsynaptic density membrane
- GO:0098843 postsynaptic endocytic zone
Molecular Function
- GO:0001540 amyloid-beta binding
- GO:0004970 glutamate-gated receptor activity
- GO:0004971 AMPA glutamate receptor activity
- GO:0005515 protein binding
- GO:0099094 ligand-gated monoatomic cation channel activity
- GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process
KEGG
- hsa04024 cAMP signaling pathway
- KEGG:hsa04080 Neuroactive ligand-receptor interaction
- KEGG:hsa04082 Neuroactive ligand signaling
- KEGG:hsa04713 Circadian entrainment
- KEGG:hsa04720 Long-term potentiation
- KEGG:hsa04723 Retrograde endocannabinoid signaling
- KEGG:hsa04724 Glutamatergic synapse
- KEGG:hsa04728 Dopaminergic synapse
- KEGG:hsa04730 Long-term depression
- KEGG:hsa05014 Amyotrophic lateral sclerosis
- KEGG:hsa05016 Huntington disease
- KEGG:hsa05017 Spinocerebellar ataxia
- KEGG:hsa05022 Pathways of neurodegeneration - multiple diseases
- KEGG:hsa05030 Cocaine addiction
- KEGG:hsa05031 Amphetamine addiction
- KEGG:hsa05033 Nicotine addiction
Reactome
- R-hsa-442755 activation of nmda receptors and postsynaptic events
- R-hsa-9620244 long term potentiation
- R-hsa-9022699 mecp2 regulates neuronal receptors and channels
- R-hsa-112316 neuronal system
- R-hsa-112314 neurotransmitter receptors and postsynaptic signal transmission
- R-hsa-73857 rna polymerase ii transcription
- R-hsa-399719 trafficking of ampa receptors
- R-hsa-416993 trafficking of glur2 containing ampa receptors
- R-hsa-8986944 transcriptional regulation by mecp2
- R-hsa-112315 transmission across chemical synapses
- R-hsa-438066 unblocking of nmda receptors glutamate binding and activation
Mediation Categories
Clinical-translation mediationFusion and delivery mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
12 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| GRIA2 | PRKCB | P05771 | S | 683 | phosphorylation | KEA | KEA:17570479 |
| GRIA2 | PRKCB | P05771 | S | 717 | phosphorylation | KEA | KEA:17570479 |
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Ligand-Receptor Signaling
41 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| transmembrane | transmembrane | UniProt_location | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | Yes | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | Yes | No |
| transmembrane | transmembrane | GO_Intercell | No | No | No | Yes | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | Yes | No |
| transmembrane | transmembrane | TopDB | No | No | No | Yes | No |
| transmembrane | transmembrane | LOCATE | No | No | No | Yes | No |
| transmembrane | transmembrane | Ramilowski_location | No | No | No | Yes | No |
| transmembrane | transmembrane | OmniPath | No | No | No | Yes | No |
| peripheral | peripheral | UniProt_topology | No | No | No | Yes | No |
Regulatory Interaction Network
5 records.
Protein Complex Composition
4 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| GluA1-GluA2 AMPA receptor complex | GRIA1GRIA2 | P42261P42262 | 2:2 | ComplexPortal | intact:EBI-49222044 | 1750669934079129334508481475529230872532 |
| PICK1-GRIP1-GLUR2 complex | GRIA2GRIP1PICK1 | P42262Q9NRD5Q9Y3R0 | 1:1:1 | CompleatCORUM | CORUM:2272Compleat:HC2901 | 16055064 |
| Stargazin-Glu2A-mu3 complex | AP3M2CACNG2GRIA2 | P42262P53677Q9Y698 | 0:0:0 | CORUM | CORUM:6199 | 24217640 |
| GRIA2 | P42262 | 3 | PDB | PDB:2xhdPDB:3rn8PDB:3r7xPDB:2wjxPDB:5zg0PDB:8i0bPDB:5h8sPDB:5ybgPDB:5zg2PDB:7f3oPDB:5ybfPDB:3rnnPDB:5zg1PDB:5zg3 |
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Polymer Precipitation | Western blotting | 1 | 38731868 |
Sequence, Structure & Domains
Sequences
Length
883
Mass
98,821
Sequence
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI
Alternative Products
Event=Alternative splicing; Named isoforms=4; Name=Flop; IsoId=P42262-1; Sequence=Displayed; Name=Flip; IsoId=P42262-2; Sequence=VSP_053350; Name=3; Synonyms=Long; IsoId=P42262-3; Sequence=VSP_029309; Name=4; IsoId=P42262-4; Sequence=VSP_055920, VSP_053350
Alternative Sequence
1..47; Missing (in isoform 4); 765..800; NAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGD -> TPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSG (in isoform Flip and isoform 4); 848..883; VAKNAQNINPSSSQNSQNFATYKEGYNVYGIESVKI -> MTLNDAMRNKARLSITGSTGENGRVMTPEFPKAVHAVPYVSPGMGMNVSVTDLS (in isoform 3)
3D Structural Models
Turn
94..96; 282..284; 391..393; 424..426; 476..478; 717..719; 789..791
Helix
38..51; 70..83; 97..107; 133..142; 159..171; 188..191; 193..201; 213..225; 230..232; 247..249; 268..277; 295..316; 341..349; 433..435; 438..441; 445..457; 483..489; 504..507; 657..661; 675..682; 686..697; 707..716; 727..734; 764..776; 779..788
Beta Strand
27..34; 58..65; 88..90; 111..113; 125..127; 147..152; 174..179; 206..211; 234..237; 239..241; 256..262; 289..291; 353..355; 358..360; 366..368; 373..379; 382..390; 394..397; 416..420; 427..429; 442..444; 461..465; 494..501; 510..512; 516..519; 521..526; 664..669; 671..674; 704..706; 721..726; 741..745; 751..758
3D Structure
X-ray crystallography (16)
Domain & Motif Annotations
Domain (CC)
The M4 transmembrane segment mediates tetramerization and is required for cell surface expression.
Region
867..877; Required for interaction with IQSEC1
Protein Families
- Glutamate-gated ion channel (TC 1.A.10.1) family
- GRIA2 subfamily
Sequence Similarities
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
Clinical Relevance
Disease Involvement
Autism spectrum disorderDisease variantEpilepsyIntellectual disability
Related Diseases
Biomarker
Approved; Phase 2
Drug Targets
Clinical trial targetSuccessful targetDiscontinued targetLiterature-reported target
Drugs
SELURAMPANELBUTABARBITALBUTOBARBITALPENTOBARBITAL SODIUMMK-8777PESAMPATORPHENOBARBITALMEPHOBARBITALGLUTAMIC ACIDTELAGLENASTATHEXOBARBITALTEZAMPANELTALBUTALPERAMPANELTOPIRAMATESECOBARBITALIRAMPANELTAK-653ZONAMPANELMETHARBITALTALAMPANELPRIMIDONETHIOPENTALBECAMPANELMIBAMPATORBUTALBITALFARAMPATORCX-717PALIRODENNULLCX1739DASOLAMPANELIPN60090
Antibody
Interaction Protein
ENSG00000073969
Interaction Count
1
Interaction Dataset
intact_biogrid