Protein detail

TEC

Tyrosine-protein kinase Tec (EC 2.7.10.2)

Protein symbol TEC	UniProt ID P42680	EVMP score 0.63
Frequency 9	Transmembrane count	Protein classification EnzymesPlasma proteinsPredicted intracellular proteins

Basic Information

Protein Names

Tyrosine-protein kinase Tec (EC 2.7.10.2)

Protein Class

EnzymesPlasma proteinsPredicted intracellular proteins

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Ensembl

ENSG00000135605

Entrez Gene Symbol

TEC

Gene Synonym

PSCTK4

Gene Description

Tec protein tyrosine kinase

Chromosome

Position

48135783-48269838

Frequency

EVMP Score

0.63

Fluorescence & Localization

Tissue Specificskeletal muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificchoroid plexus epithelial cell

Function & Pathway

Protein Function

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Immune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

2 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TEC	BTK	Q06187	Y	206	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 phosphoELM:12573241
TEC	ITK	Q08881	Y	206	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 phosphoELM:12573241

Ligand-Receptor Signaling

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network

9 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
TEC	P42680	STAP1	Q9ULZ2	Yes	Yes	No	NetPathSIGNORPhosphoPointHPRDHINTSPIKE_LCSPIKE	SPIKE:10518561 HPRD:10518561 HINT:10518561 NetPath:10518561 HPRD:11716489 SIGNOR:10518561 SPIKE_LC:10518561 HINT:11716489
STAP1	Q9ULZ2	TEC	P42680	Yes	Yes	No	NetPathSIGNORHPRDHINTSPIKE_LCSPIKE	SPIKE:10518561 HPRD:10518561 HINT:10518561 NetPath:10518561 HPRD:11716489 SIGNOR:10518561 SPIKE_LC:10518561 HINT:11716489
TEC	P42680	PTN18	Q99952	Yes	No	No	SPIKEPhosphoSite_MIMPMIMPNetPathHPRD_MIMPPhosphoSite_norefPhosphoPointiPTMnetProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASPIKE_LCPhosphoSitePhosphoSite_ProtMapper	PhosphoSite:14679216 NetPath:14679216 HPRD:14679216 SPIKE_LC:14679216 KEA:14679216 HPRD:15588985 PhosphoSite:23322602 SPIKE:14679216 ProtMapper:14679216 PhosphoSite:19410646
TEC	P42680	BTK	Q06187	Yes	No	Yes	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAKinexus_KEAHPRD_KEASIGNOR_ProtMapperHPRD-phosPhosphoSite_ProtMapper	HPRD-phos:11598012 KEA:11598012 ProtMapper:8629002 HPRD-phos:12573241 ProtMapper:8630736 ProtMapper:12445832 KEA:8630736 KEA:12573241 HPRD:12445832 HPRD:8629002 ProtMapper:11598012 ProtMapper:12573241 HPRD:8630736 SIGNOR:12573241 KEA:12445832 HPRD:12573241 HPRD:11598012 KEA:8629002 HPRD-phos:8629002 ProtMapper:16497976 HPRD-phos:8630736 HPRD-phos:16497976 HPRD-phos:12445832
BTK	Q06187	TEC	P42680	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPPhosphoSite_norefPhosphoPointSIGNORProtMapperiPTMnetHPRDPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:12573241 HPRD:8630736 phosphoELM:12573241 KEA:12573241 SIGNOR:12573241 HPRD:12445832 HPRD:12573241 HPRD:11598012 HPRD:8629002
TEC	P42680	MAF	O75444	Yes	Yes	No	RLIMS-P_ProtMapperSIGNORProtMapper	ProtMapper:25993510 SIGNOR:25993510
TEC	P42680	BMX	P51813	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	ProtMapper:12573241 phosphoELM:12573241 KEA:12573241 SIGNOR:12573241 HPRD:12573241
ITK	Q08881	TEC	P42680	Yes	Yes	No	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetSIGNORProtMapperPhosphoSite_KEAKEAKinexus_KEAphosphoELM_KEAphosphoELMSIGNOR_ProtMapperPhosphoSite_ProtMapper	KEA:12573241 SIGNOR:12573241 ProtMapper:12573241 phosphoELM:12573241
TEC	P42680	FGF2	P09038	Yes	No	No	dbPTMiPTMnetPhosphoSite	PhosphoSite:27382052 dbPTM:20230531

Protein Complex Composition

15 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
ATG5-ATG12-TECPR1 complex	ATG12 ATG5 TECPR1	O94817 Q7Z6L1 Q9H1Y0	1:1:1	ComplexPortal	PDB:4tq1	14755292 25787994
	ATAD3A ATAD3B CISD1 CISD2 DPM1 HADHB LCOR NDUFB10 PHB1 PHB2 RIC3 SLC25A3 SLC25A4 SLC25A6 SSR4 TECR TSPO VDAC1 VDAC2 VDAC3	B1AH88 O60762 O96000 P12235 P12236 P21796 P35232 P45880 P51571 P55084 Q00325 Q5T9A4 Q7Z5B4 Q8N5K1 Q96JN0 Q99623 Q9NVI7 Q9NZ01 Q9NZ45 Q9Y277	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	CEP83 CKAP5 NME8 POTEB2 POTEC POTED REPIN1 SLAIN1 TACC2 TRIM23 ZNF672	B2RU33 H3BUK9 O95359 P36406 Q14008 Q499Z4 Q86YR6 Q8N427 Q8ND83 Q9BWE0 Q9Y592	0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	POTEB2 POTEC POTED SLAIN1 TRIM23	B2RU33 H3BUK9 P36406 Q86YR6 Q8ND83	0:0:0:0:0	hu.MAP2
	POTEC POTED SLAIN1	B2RU33 Q86YR6 Q8ND83	0:0:0	hu.MAP2
	ATAD3A IPO5 MTCH2 SLC25A3 TECR TMCO1 UQCRC2	O00410 P22695 Q00325 Q9NVI7 Q9NZ01 Q9UM00 Q9Y6C9	0:0:0:0:0:0:0	hu.MAP2
	TECPR2 TGFBRAP1 VPS11 VPS16 VPS18 VPS33A VPS41 VPS8	O15040 P49754 Q8N3P4 Q8WUH2 Q96AX1 Q9H269 Q9H270 Q9P253	0:0:0:0:0:0:0:0	hu.MAP2
	AHSA1 ETFA HSD17B12 JAK2 KDELR2 LIPE RAB1A RAB2A RAB5A RAB6A RAB7A RABGGTB RPN1 SSR2 TECR	O60674 O95433 P04843 P13804 P20339 P20340 P33947 P43308 P51149 P53611 P61019 P62820 Q05469 Q53GQ0 Q9NZ01	1:1:1:1:1:1:1:1:1:1:1:1:1:1:1	NetworkBlastCompleat	Compleat:HC7864
	ATAD3A ATAD3B CISD1 CISD2 DPM1 HADHB LCOR NDUFB10 PHB1 PHB2 RIC3 SLC25A3 SLC25A4 SLC25A6 SSR4 TECR TSPO VDAC1 VDAC2 VDAC3	O60762 O96000 P12235 P12236 P21796 P30536 P35232 P45880 P51571 P55084 Q00325 Q5T9A4 Q7Z5B4 Q8N5K1 Q96JN0 Q99623 Q9NVI7 Q9NZ01 Q9NZ45 Q9Y277	0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0:0	hu.MAP2
	RPN1 SMNDC1 SND1 SSR3 TECR	O75940 P04843 Q7KZF4 Q9NZ01 Q9UNL2	0:0:0:0:0	Havugimana2012	Havugimana2012:C_436

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Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Protein Organic Solvent Precipitation	Mass spectrometry	1	32384937

Sequence, Structure & Domains

Sequences

Length

631

Mass

73,581

Sequence

MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEETFGR

3D Structural Models

Helix

56..58; 96..110

Beta Strand

3..14; 19..21; 26..41; 45..47; 53..55; 61..64; 69..71; 74..76; 78..83; 88..92; 118..120; 132..134; 143..145

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Zinc Finger

113..149; Btk-type

Domain (CC)

The PH domain mediates the binding to inositol polyphosphate and phosphoinositides, leading to its targeting to the plasma membrane. It is extended in the BTK kinase family by a region designated the TH (Tec homology) domain, which consists of about 80 residues preceding the SH3 domain.; DOMAIN: The SH3 domain is essential for its targeting to activated CD28 costimulatory molecule.

Domain (FT)

4..111; PH; 179..239; SH3; 247..345; SH2; 370..623; Protein kinase

Region

157..178; Disordered

Protein Families

Protein kinase superfamily
Tyr protein kinase family
TEC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Clinical Relevance

Drugs

ZYBT1 PF-06651600 NEMTABRUTINIB INOSITOL ACALABRUTINIB DASATINIB ANHYDROUS NULL JNJ-64264681 COMPOUND 38 [PMID: 24915291]COMPOUND 25 [PMID: 31260299]IBRUTINIB COMPOUND 9 [PMID: 26006010]COMPOUND 31 [PMID: 24915291]PRN694

Antibody

HPA005733 HPA024657