Protein detail

TXK

Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)

Entry name TXK	UniProt ID P42681	EVMP confidence score 0.38
Supporting publications (n) 2	Transmembrane count	Protein classification

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information6

Protein Names

Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Ensembl

ENSG00000074966

Entrez Gene Symbol

TXK

Supporting publications (n)

EVMP confidence score

0.38

Fluorescence & Localization1

Function & Pathway7

Protein Function (4)

ENZYME proteins:Transferases
Enzymes
Kinases:Tyr protein kinases
Predicted intracellular proteins

Cellular Component (6)

Molecular Function (3)

Biological Process (3)

KEGG

hsa04670 Leukocyte transendothelial migration

Reactome (3)

Mediation Categories

Immune mediation

Relations & Evidence17

Enzyme-Mediated Modification (4)

4 records.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
TXK	FYN	P06241	Y	420	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEASIGNOR_ProtMapper	KEA:11353545 ProtMapper:11353545 dbPTM:12081135 SIGNOR:11353545 HPRD:11353545
TXK	SRC	P12931	Y	420	phosphorylation	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper	KEA:11353545 ProtMapper:11353545 SIGNOR:11353545 HPRD:11353545
TXK	IGF1R	P08069	Y	420	phosphorylation	KEA	KEA:17570479
TXK	LYN	P07948	Y	420	phosphorylation	KEA	KEA:17570479

Ligand-Receptor Signaling (8)

8 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	OmniPath	No	Yes	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	UniProt_location	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	No	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	No	No
receptor	receptor	scConnect	No	Yes	No	No	No

Regulatory Interaction Network (4)

4 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
FYN	P06241	TXK	P42681	Yes	Yes	No	HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAHPRDWangHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperNetPathSPIKE_LCSPIKE	SPIKE:11353545 KEA:11353545 ProtMapper:11353545 SPIKE_LC:11353545 SIGNOR:11353545 dbPTM:12081135 HPRD-phos:11353545 HPRD:11353545 NetPath:11353545 ProtMapper:18027204
TXK	P42681	LCP2	Q13094	Yes	Yes	No	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	HINT:8702662 KEA:15388330 ProtMapper:9047237 HPRD-phos:8702662 KEA:9047237 SIGNOR:10660534 KEA:12817019 SIGNOR:8892604 iPTMnet:8702662 HINT:9047237 phosphoELM:8892604 ProtMapper:8702662 KEA:10660534 KEA:8892604 HPRD:8702662 HPRD-phos:10660534 ProtMapper:10660534 HPRD:9047237 KEA:12640123 KEA:8702662 ProtMapper:8892604 HINT:10660534 HPRD-phos:9047237 HPRD:10660534
TXK	P42681	CTLA4	P16410	Yes	Yes	No	WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDdbPTMPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos	SIGNOR:9813138 iPTMnet:9813138 phosphoELM:9813138 ProtMapper:9813138 KEA:9813138 HPRD-phos:9813138 KEA:10842319 dbPTM:9175836 HPRD:9813138 KEA:9973379 dbPTM:9813138
SRC	P12931	TXK	P42681	Yes	Yes	No	phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos	KEA:11353545 ProtMapper:11353545 SIGNOR:11353545 HPRD-phos:11353545 HPRD:11353545

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry；Western blotting；RNA Sequencing；Small RNA sequencing (Illumina HiSeq 2002)	1	40748658

Sequence, Structure & Domains12

Sequences

Length

527

Mass

61,258

Sequence

MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW

3D Structural Models

Helix

157..167; 224..231

Beta Strand

148..151; 175..178; 181..189; 193..197; 200..207; 213..218; 237..239

3D Structure

NMR spectroscopy (1)

Domain & Motif Annotations

Compositional Bias

51..64; Polar residues

Motif

68..73; Nuclear localization signal

Domain (FT)

82..142; SH3; 150..246; SH2; 271..527; Protein kinase

Region

35..79; Disordered

Protein Families (3)

Protein kinase superfamily
Tyr protein kinase family
TEC subfamily

Sequence Similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

Clinical Relevance1

Drugs (2)

PF-06651600 HESPERADIN

Supporting Publications2

PMID	Title	Abstract
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available
40098346	Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays.	No abstract available