Protein detail
TXK
Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)
Entry name TXK | UniProt ID | EVMP confidence score 0.28 |
Supporting publications (n) 2 | Transmembrane count | Protein classification |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Tyrosine-protein kinase TXK (EC 2.7.10.2) (Protein-tyrosine kinase 4) (Resting lymphocyte kinase)
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- Predicted intracellular proteins
Ensembl
Entrez Gene Symbol
Supporting publications (n)
2
EVMP confidence score
0.28
Fluorescence & Localization
Function & Pathway
Protein Function (4)
- ENZYME proteins:Transferases
- Enzymes
- Kinases:Tyr protein kinases
- Predicted intracellular proteins
Cellular Component (6)
Molecular Function (3)
Biological Process (3)
Reactome (3)
Mediation Categories
Immune mediation
Relations & Evidence17
Enzyme-Mediated Modification (4)
4 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| TXK | FYN | P06241 | Y | 420 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEASIGNOR_ProtMapper | KEA:11353545ProtMapper:11353545dbPTM:12081135SIGNOR:11353545HPRD:11353545 |
| TXK | SRC | P12931 | Y | 420 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | KEA:11353545ProtMapper:11353545SIGNOR:11353545HPRD:11353545 |
| TXK | IGF1R | P08069 | Y | 420 | phosphorylation | KEA | KEA:17570479 |
| TXK | LYN | P07948 | Y | 420 | phosphorylation | KEA | KEA:17570479 |
Ligand-Receptor Signaling (8)
8 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | Yes | ||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath | |||||
| plasma_membrane | plasma_membrane | UniProt_location | |||||
| plasma_membrane | plasma_membrane | OmniPath | |||||
| receptor | receptor | scConnect | Yes |
Regulatory Interaction Network (4)
4 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| FYN | P06241 | TXK | P42681 | Yes | Yes | HPRD_MIMPSIGNORProtMapperdbPTMPhosphoSite_KEAHPRDWangHPRD-phosphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEASIGNOR_ProtMapperREACH_ProtMapperNetPathSPIKE_LCSPIKE | SPIKE:11353545KEA:11353545ProtMapper:11353545SPIKE_LC:11353545SIGNOR:11353545dbPTM:12081135HPRD-phos:11353545HPRD:11353545NetPath:11353545ProtMapper:18027204 | |
| TXK | P42681 | LCP2 | Q13094 | Yes | Yes | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDHINTPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos | HINT:8702662KEA:15388330ProtMapper:9047237HPRD-phos:8702662KEA:9047237SIGNOR:10660534KEA:12817019SIGNOR:8892604iPTMnet:8702662HINT:9047237phosphoELM:8892604ProtMapper:8702662KEA:10660534KEA:8892604HPRD:8702662HPRD-phos:10660534ProtMapper:10660534HPRD:9047237KEA:12640123KEA:8702662ProtMapper:8892604HINT:10660534HPRD-phos:9047237HPRD:10660534 | |
| TXK | P42681 | CTLA4 | P16410 | Yes | Yes | WangphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDdbPTMPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperHPRD-phos | SIGNOR:9813138iPTMnet:9813138phosphoELM:9813138ProtMapper:9813138KEA:9813138HPRD-phos:9813138KEA:10842319dbPTM:9175836HPRD:9813138KEA:9973379dbPTM:9813138 | |
| SRC | P12931 | TXK | P42681 | Yes | Yes | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapperHPRD-phos | KEA:11353545ProtMapper:11353545SIGNOR:11353545HPRD-phos:11353545HPRD:11353545 |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion Chromatography | Mass spectrometry；Western blotting；RNA Sequencing；Small RNA sequencing (Illumina HiSeq 2002) | 1 | 40748658 |
Sequence, Structure & Domains
Sequences
Length
527
Mass
61,258
Sequence
MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSNTGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWWKARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
3D Structural Models
Helix
157..167; 224..231
Beta Strand
148..151; 175..178; 181..189; 193..197; 200..207; 213..218; 237..239
3D Structure
NMR spectroscopy (1)
Domain & Motif Annotations
Compositional Bias
51..64; Polar residues
Motif
68..73; Nuclear localization signal
Domain (FT)
82..142; SH3; 150..246; SH2; 271..527; Protein kinase
Region
35..79; Disordered
Protein Families (3)
- Protein kinase superfamily
- Tyr protein kinase family
- TEC subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.
Clinical Relevance
Drugs (2)
Supporting Publications2
| PMID | Title | Related sentences |
|---|---|---|
| 38731868 | The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer. | No related sentences available |
| 40098346 | Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays. | No related sentences available |