Protein detail
WASP
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Protein symbol WASP | UniProt ID | EVMP score 0.60 |
Frequency 15 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Protein Class
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym
IMD2THCWASPWASPA
Gene Description
WASP actin nucleation promoting factor
Chromosome
X
Position
48676596-48691431
Frequency
15
EVMP Score
0.60
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes
- Disease related genes
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-202433 generation of second messenger molecules
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-9664407 parasite infection
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
- R-hsa-5663213 rho gtpases activate wasps and waves
- R-hsa-9012999 rho gtpase cycle
- R-hsa-195258 rho gtpase effectors
- R-hsa-9716542 signaling by rho gtpases miro gtpases and rhobtb3
- R-hsa-202403 tcr signaling
Mediation Categories
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
21 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| WAS | HCK | P08631 | Y | 291 | phosphorylation | PhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDdbPTMKEAphosphoELMSIGNOR_ProtMapperPhosphoSite | HPRD:10068673KEA:12769847ProtMapper:12235133dbPTM:15592455HPRD:19901323HPRD:12769846ProtMapper:14707117HPRD:16497976dbPTM:18083107dbPTM:14707117KEA:12769846phosphoELM:12235133KEA:9742969dbPTM:19690332KEA:18088087HPRD:9742969SIGNOR:12235133KEA:15592455KEA:12235133KEA:10068673dbPTM:18088087HPRD:12235133HPRD:18088087dbPTM:12235133 |
| WAS | BTK | Q06187 | Y | 291 | phosphorylation | PhosphoNetworksSparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDReactome_ProtMapperKEAphosphoELMSIGNOR_ProtMapper | HPRD:10068673HPRD:12769846KEA:12769847ProtMapper:14707117KEA:9742969HPRD:12235133HPRD:18088087SIGNOR:10068673HPRD:16497976KEA:18088087HPRD:9742969phosphoELM:10068673KEA:15592455KEA:12235133KEA:10068673KEA:12769846ProtMapper:10068673HPRD:19901323 |
| WAS | CSNK2A1 | P68400 | S | 484 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:12769847ProtMapper:12769847phosphoELM:12769847KEA:12769847SIGNOR:12769847HPRD:18088087KEA:18088087 |
| WAS | CSNK2A1 | P68400 | S | 483 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | HPRD:12769847ProtMapper:12769847KEA:12769847SIGNOR:12769847HPRD:18088087 |
| WAS | CSNK2A1 | P68400 | Y | 291 | phosphorylation | KEA | KEA:12769847KEA:9742969KEA:15592455KEA:12235133KEA:10068673KEA:12769846 |
| WAS | FYN | P06241 | Y | 291 | phosphorylation | dbPTMSparser_ProtMapperProtMapper | dbPTM:19690332dbPTM:18083107dbPTM:14707117dbPTM:12235133dbPTM:15592455ProtMapper:25709608dbPTM:18088087 |
| WAS | CSNK2A2 | P19784 | S | 483 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:12769847ProtMapper:12769847KEA:12769847SIGNOR:12769847HPRD:18088087 |
| WAS | CSNK2A2 | P19784 | S | 484 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperHPRDKEASIGNOR_ProtMapper | HPRD:12769847ProtMapper:12769847KEA:12769847SIGNOR:12769847HPRD:18088087 |
| WAS | PTPN12 | Q05209 | Y | 291 | dephosphorylation | HPRDSIGNOR | HPRD:11711533SIGNOR:14707117 |
| WAS | PTPN12 | Q05209 | Y | 291 | phosphorylation | SIGNOR_ProtMapperProtMapper | ProtMapper:14707117 |
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Ligand-Receptor Signaling
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
Regulatory Interaction Network
9 records.
Protein Complex Composition
49 records.
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Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
502
Mass
52,913
Sequence
MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGEDQAGDEDEDDEWDD
3D Structural Models
Turn
235..237; 254..256; 260..262; 272..275
Helix
265..271; 278..281; 284..296; 299..309; 432..440
Beta Strand
245..250
3D Structure
NMR spectroscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
201..211; Polar residues; 341..419; Pro residues; 486..502; Acidic residues
Repeat
337..346; GRSGPLPPXP motif 1; 376..385; GRSGPLPPXP motif 2
Domain (CC)
The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand.; DOMAIN: The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation.
Domain (FT)
39..148; WH1; 238..251; CRIB; 430..447; WH2
Region
146..240; Disordered; 307..502; Disordered
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variant
Related Diseases
Biomarker
Phase 3
Drug Targets
Clinical trial target
Drugs
Interaction Protein
ENSG00000010810ENSG00000070831ENSG00000071051ENSG00000115935ENSG00000130340ENSG00000140368ENSG00000158092
Interaction Count
7
Interaction Dataset
intact_biogrid