Protein detail
WASP
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Entry name WASP | UniProt ID | EVMP confidence score 0.47 |
Supporting publications (n) 15 | Transmembrane count | Protein classification Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins |
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.70High >= 0.60Medium >= 0.40Low >= 0.30Basic Information
Protein Names
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Protein Class (4)
Cancer-related genesDisease related genesHuman disease related genesPredicted intracellular proteins
Protein Function (5)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes
- Disease related genes
Ensembl
Entrez Gene Symbol
Gene Synonym (4)
IMD2THCWASPWASPA
Gene Description
WASP actin nucleation promoting factor
Chromosome
X
Position
48676596-48691431
Supporting publications (n)
15
EVMP confidence score
0.47
Fluorescence & Localization
Tissue Specificchoroid plexusCell SpecificEndometrial ciliated cellsSingle-Nuclei Brain Specificchoroid plexus epithelial cell
Function & Pathway
Protein Function (5)
- Human disease related genes:Cardiovascular diseases:Hematologic diseases
- Predicted intracellular proteins
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Cancer-related genes
- Disease related genes
Cellular Component (10)
Molecular Function (8)
Biological Process (3)
KEGG (6)
Reactome (15)
- R-hsa-1280218 adaptive immune system
- R-hsa-9013148 cdc42 gtpase cycle
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-202433 generation of second messenger molecules
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-9658195 leishmania infection
- R-hsa-9664407 parasite infection
- R-hsa-9013149 rac1 gtpase cycle
- R-hsa-9013409 rhoj gtpase cycle
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Mediation Categories (4)
Clinical-translation mediationFusion and delivery mediationImmune mediationReceptor-signaling mediation
Relations & Evidence85
Enzyme-Mediated Modification (21)
21 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| WAS | SRC | P12931 | Y | 291 | phosphorylation | Li2012REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:22279563 |
| WAS | TEC | P42680 | Y | 291 | phosphorylation | Li2012 | |
| WAS | ABL1 | P00519 | Y | 291 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| WAS | LCK | P06239 | Y | 291 | phosphorylation | Sparser_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:15699074 |
| WAS | TNK2 | Q07912 | Y | 291 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| WAS | LYN | P07948 | Y | 291 | phosphorylation | phosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPProtMapperPhosphoSitePhosphoSite_ProtMapper | |
| WAS | PTK2 | Q05397 | Y | 291 | phosphorylation | Reactome_ProtMapperProtMapper | |
| WAS | CDC42 | P60953 | Y | 291 | phosphorylation | REACH_ProtMapperSparser_ProtMapperProtMapper | ProtMapper:12769846ProtMapper:25758716 |
| WAS | FOXH1 | O75593 | Y | 291 | phosphorylation | Sparser_ProtMapperProtMapper | ProtMapper:25147952 |
| WAS | ALK | Q9UM73 | Y | 102 | phosphorylation | RLIMS-P_ProtMapperProtMapper | ProtMapper:27694894 |
Ligand-Receptor Signaling (5)
5 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| intracellular | intracellular | LOCATE | |||||
| intracellular | intracellular | ComPPI | |||||
| intracellular | intracellular | GO_Intercell | |||||
| intracellular | intracellular | UniProt_location | |||||
| intracellular | intracellular | OmniPath |
Regulatory Interaction Network (9)
9 records.
Protein Complex Composition (49)
49 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| WASHC4WASHC5 | Q12768Q2M389 | 0:0 | hu.MAP2 | |||
| WASHC2AWASHC4WASHC5 | Q12768Q2M389Q641Q2 | 0:0:0 | hu.MAP | |||
| SNX27WASHC2A | Q641Q2Q96L92 | 1:1 | PDB | PDB:8tttPDB:8ttuPDB:8ttv | ||
| VPS29VPS35WASHC2A | Q641Q2Q96QK1Q9UBQ0 | 4:4:4 | PDB | PDB:8rks | ||
| ABI2BRK1CYFIP1NCKAP1WASF1 | Q7L576Q8WUW1Q92558Q9NYB9Q9Y2A7 | 1:1:1:1:1 | PDB | PDB:3p8cPDB:7uscPDB:4n78 | ||
| ABI2CYFIP1CYFIP2NCKAP1WASF1 | Q7L576Q92558Q96F07Q9NYB9Q9Y2A7 | 0:0:0:0:0 | hu.MAP | |||
| NCKAP1WASF1 | Q92558Q9Y2A7 | 0:0 | hu.MAP | |||
| CYFIP2WASF3 | Q96F07Q9UPY6 | 0:0 | hu.MAP2 | |||
| WASHC2CWASHC3 | Q9Y3C0Q9Y4E1 | 0:0 | hu.MAP2 |
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Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains
Sequences
Length
502
Mass
52,913
Sequence
MSGGPMGGRPGGRGAPAVQQNIPSTLLQDHENQRLFEMLGRKCLTLATAVVQLYLALPPGAEHWTKEHCGAVCFVKDNPQKSYFIRLYGLQAGRLLWEQELYSQLVYSTPTPFFHTFAGDDCQAGLNFADEDEAQAFRALVQEKIQKRNQRQSGDRRQLPPPPTPANEERRGGLPPLPLHPGGDQGGPPVGPLSLGLATVDIQNPDITSSRYRGLPAPGPSPADKKRSGKKKISKADIGAPSGFKHVSHVGWDPQNGFDVNNLDPDLRSLFSRAGISEAQLTDAETSKLIYDFIEDQGGLEAVRQEMRRQEPLPPPPPPSRGGNQLPRPPIVGGNKGRSGPLPPVPLGIAPPPPTPRGPPPPGRGGPPPPPPPATGRSGPLPPPPPGAGGPPMPPPPPPPPPPPSSGNGPAPPPLPPALVPAGGLAPGGGRGALLDQIRQGIQLNKTPGAPESSALQPPPQSSEGLVGALMHVMQKRSRAIHSSDEGEDQAGDEDEDDEWDD
3D Structural Models
Turn
235..237; 254..256; 260..262; 272..275
Helix
265..271; 278..281; 284..296; 299..309; 432..440
Beta Strand
245..250
3D Structure
NMR spectroscopy (4); X-ray crystallography (2)
Domain & Motif Annotations
Compositional Bias
201..211; Polar residues; 341..419; Pro residues; 486..502; Acidic residues
Repeat
337..346; GRSGPLPPXP motif 1; 376..385; GRSGPLPPXP motif 2
Domain (CC)
The WH1 (Wasp homology 1) domain may bind a Pro-rich ligand.; DOMAIN: The CRIB (Cdc42/Rac-interactive-binding) region binds to the C-terminal WH2 domain in the autoinhibited state of the protein. Binding of Rho-type GTPases to the CRIB induces a conformation change and leads to activation.
Domain (FT)
39..148; WH1; 238..251; CRIB; 430..447; WH2
Region
146..240; Disordered; 307..502; Disordered
Clinical Relevance
Disease Involvement (2)
Cancer-related genesDisease variant
Related Diseases
Biomarker
Phase 3
Drug Targets
Clinical trial target
Drugs
Interaction Protein (7)
ENSG00000010810ENSG00000070831ENSG00000071051ENSG00000115935ENSG00000130340ENSG00000140368ENSG00000158092
Interaction Count
7
Interaction Dataset
intact_biogrid
Supporting Publications15
| PMID | Title | Related sentences |
|---|---|---|
| 10451508 | Simultaneous analysis of the cyan, yellow and green fluorescent proteins by flow cytometry using single-laser excitation at 458 nm. | No related sentences available |
| 26801919 | Exosomes Secreted by Apoptosis-Resistant Acute Myeloid Leukemia (AML) Blasts Harbor Regulatory Network Proteins Potentially Involved in Antagonism of Apoptosis. | No related sentences available |
| 27723984 | Proteomic and Bioinformatic Characterization of Extracellular Vesicles Released from Human Macrophages upon Influenza A Virus Infection. | No related sentences available |
| 30550287 | Label-Free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages Treated with IFN-α Identifies Antiviral Proteins Enriched in Exosomes. | No related sentences available |
| 34355211 | A size-exclusion-based approach for purifying extracellular vesicles from human plasma. | No related sentences available |
| 34754007 | Plasma extracellular vesicles in people living with HIV and type 2 diabetes are related to microbial translocation and cardiovascular risk. | No related sentences available |
| 37702715 | One-Pot Analytical Pipeline for Efficient and Sensitive Proteomic Analysis of Extracellular Vesicles. | No related sentences available |
| 38225453 | Deep proteomic analysis of obstetric antiphospholipid syndrome by DIA-MS of extracellular vesicle enriched fractions. | No related sentences available |
| 38489029 | Circulating small extracellular vesicles mediate vascular hyperpermeability in diabetes. | No related sentences available |
| 38556629 | Differential effects of physiological agonists on the proteome of platelet-derived extracellular vesicles. | No related sentences available |
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