Protein detail
EAA3
Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
Entry name EAA3 | UniProt ID | EVMP confidence score 0.38 |
Supporting publications (n) | Transmembrane count 8 | Protein classification Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters |
EVMP confidence score
Annotation confidence score; open for threshold definitions.
Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40Basic Information12
Protein Names
Excitatory amino acid transporter 3 (Excitatory amino-acid carrier 1) (Neuronal and epithelial glutamate transporter) (Sodium-dependent glutamate/aspartate transporter 3) (Solute carrier family 1 member 1)
Protein Class (6)
Disease related genesHuman disease related genesMetabolic proteinsPotential drug targetsPredicted membrane proteinsTransporters
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Transmembrane
19..38; Helical; 62..82; Helical; 94..114; Helical; 206..229; Helical; Name=4; 239..266; Helical; Name=5; 287..308; Helical; Name=6; 354..380; Helical; Name=7; 441..462; Helical; Name=8
Transmembrane Count
8
Ensembl
Entrez Gene Symbol
Gene Synonym (3)
EAAC1EAAT3hEAAC1
Gene Description
Solute carrier family 1 member 1
Chromosome
9
Position
4490468-4587469
EVMP confidence score
0.38
Fluorescence & Localization4
Tissue SpecificbrainCell SpecificAstrocytesBlood Cell SpecificgdT-cellBlood Lineage SpecificT-cells
Function & Pathway7
Protein Function (5)
- Human disease related genes:Other diseases:Mental and behavioural disorders
- Potential drug targets
- Transporters:Electrochemical Potential-driven transporters
- Disease related genes
- Human disease related genes:Congenital disorders of metabolism:Congenital disorders of amino acid metabolism
Cellular Component (27)
- GO:0005783 endoplasmic reticulum
- GO:0005886 plasma membrane
- GO:0009897 external side of plasma membrane
- GO:0016020 membrane
- GO:0016324 apical plasma membrane
- GO:0030424 axon
- GO:0030425 dendrite
- GO:0031901 early endosome membrane
- GO:0031902 late endosome membrane
- GO:0032279 asymmetric synapse
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Molecular Function (12)
- GO:0005253 monoatomic anion channel activity
- GO:0005313 L-glutamate transmembrane transporter activity
- GO:0005314 high-affinity L-glutamate transmembrane transporter activity
- GO:0005515 protein binding
- GO:0015108 chloride transmembrane transporter activity
- GO:0015183 L-aspartate transmembrane transporter activity
- GO:0015501 glutamate:sodium symporter activity
- GO:0016595 glutamate binding
- GO:0033229 cysteine transmembrane transporter activity
- GO:0042802 identical protein binding
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Biological Process (3)
KEGG (4)
Reactome (9)
- R-hsa-5619115 disorders of transmembrane transporters
- R-hsa-210500 glutamate neurotransmitter release cycle
- R-hsa-112316 neuronal system
- R-hsa-112310 neurotransmitter release cycle
- R-hsa-425407 slc mediated transmembrane transport
- R-hsa-9958863 slc mediated transport of amino acids
- R-hsa-5619102 slc transporter disorders
- R-hsa-112315 transmission across chemical synapses
- R-hsa-382551 transport of small molecules
Mediation Categories (5)
Clinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence36
Ligand-Receptor Signaling (31)
31 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| solute_carrier | transporter | Almen2009 | No | Yes | No | No | No |
| slc1 | transporter | Surfaceome | No | Yes | No | No | No |
| slc | transporter | Surfaceome | No | Yes | No | No | No |
| transporter | transporter | OmniPath | No | Yes | No | No | No |
| transmembrane | transmembrane | UniProt_location | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_topology | No | No | No | No | No |
| transmembrane | transmembrane | UniProt_keyword | No | No | No | No | No |
| transmembrane | transmembrane | CellPhoneDB | No | No | No | No | No |
| transmembrane | transmembrane | TopDB | No | No | No | No | No |
| transmembrane | transmembrane | LOCATE | No | No | No | No | No |
Regulatory Interaction Network (1)
1 record.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| CAV1 | Q03135 | EAA3 | P43005 | Yes | No | Yes | SIGNOR | SIGNOR:26690923 |
Protein Complex Composition (3)
3 records.
| Component Name | Component Gene Symbols | Component UniProt ID | Stoichiometry | Database | Database IDs | References |
|---|---|---|---|---|---|---|
| Glutamate_byGLS2_and_SLC1A1 | GLS2SLC1A1 | P43005Q9UI32 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:Glutamate_byGLS2_and_SLC1A1 | |
| Glutamate_byGLS_and_SLC1A1 | GLSSLC1A1 | O94925P43005 | 1:1 | CellPhoneDBCellChatDB | CellPhoneDB:Glutamate_byGLS_and_SLC1A1 | |
| SLC1A1 | P43005 | 3 | PDB | PDB:8cuiPDB:9d66PDB:9d67PDB:6x3ePDB:7nsgPDB:6x2lPDB:6x3fPDB:6s3qPDB:8cuaPDB:8cv2PDB:8ctc |
Isolation & Detection Technology (1)
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Protein Organic Solvent Precipitation | Mass spectrometry | 1 | 32384937 |
Sequence, Structure & Domains10
Sequences
Length
524
Mass
57,100
Sequence
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
3D Structural Models
Turn
15..18; 84..86; 119..121; 124..126; 408..410
Helix
19..41; 46..52; 54..65; 67..80; 87..116; 138..149; 156..158; 212..226; 230..232; 234..269; 277..281; 283..298; 300..308; 313..318; 321..330; 334..336; 337..346; 352..365; 368..384; 391..404; 414..426; 430..432; 433..437; 440..465; 468..476
Beta Strand
160..167; 201..209; 270..272; 309..311
3D Structure
Electron microscopy (22)
Domain & Motif Annotations
Domain (CC)
Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.
Protein Families (2)
- Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
- SLC1A1 subfamily
Sequence Similarities
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily.
Clinical Relevance6
Disease Involvement (2)
Disease variantSchizophrenia
Drugs (15)
Antibody
Interaction Protein (10)
ENSG00000012232ENSG00000079215ENSG00000101337ENSG00000105245ENSG00000109016ENSG00000115902ENSG00000116857ENSG00000169692ENSG00000175348ENSG00000177150
Interaction Count
10
Interaction Dataset
biogrid_bioplex