Protein detail

GUC1A

Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A)

Entry name GUC1A	UniProt ID P43080	EVMP confidence score 0.50
Supporting publications (n) 2	Transmembrane count	Protein classification Disease related genesHuman disease related genesPredicted intracellular proteins

EVMP confidence score

Annotation confidence score; open for threshold definitions.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information11

Protein Names

Guanylyl cyclase-activating protein 1 (GCAP 1) (Guanylate cyclase activator 1A)

Protein Class (3)

Disease related genesHuman disease related genesPredicted intracellular proteins

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Ensembl

ENSG00000048545

Entrez Gene Symbol

GUCA1A

Gene Synonym (8)

C6orf131COD3CORD14dJ139D8.6GCAPGCAP1GUCAGUCA1

Gene Description

Guanylate cyclase activator 1A

Chromosome

Position

42173364-42181338

Supporting publications (n)

EVMP confidence score

0.50

Fluorescence & Localization3

Cell SpecificChoroid plexus epithelial cellsSingle-Nuclei Brain Specificependymal cellBlood Cell Specificplasmacytoid DC

Function & Pathway7

Protein Function (3)

Disease related genes
Predicted intracellular proteins
Human disease related genes:Nervous system diseases:Eye disease

Cellular Component (3)

Molecular Function (4)

Biological Process (3)

KEGG

hsa04744 Phototransduction

Reactome (3)

Mediation Categories

Receptor-signaling mediation

Relations & Evidence9

Ligand-Receptor Signaling (7)

7 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
extracellular	extracellular	OmniPath	No	No	No	No	No
intracellular	intracellular	ComPPI	No	No	No	No	No
intracellular	intracellular	GO_Intercell	No	No	No	No	No
intracellular	intracellular	OmniPath	No	No	No	No	No
ligand	ligand	scConnect	Yes	No	No	No	No
ligand	ligand	Guide2Pharma	Yes	No	No	No	No
ligand	ligand	OmniPath	Yes	No	No	No	No

Protein Complex Composition (1)

1 record.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GUCA1A	P43080	0	Guide2Pharma

Isolation & Detection Technology (1)

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationSize Exclusion Chromatography	Mass spectrometry	2	40748658 28590090

Sequence, Structure & Domains5

Sequences

Length

201

Mass

22,920

Sequence

MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIQAIRAINPCSDTTMTAEEFTDTVFSKIDVNGDGELSLEEFIEGVQKDQMLLDTLTRSLDLTRIVRRLQNGEQDEEGADEAAEAAG

Domain & Motif Annotations

Domain (CC)

Binds three calcium ions (via EF-hands 2, 3 and 4) when calcium levels are high. Binds Mg(2+) when calcium levels are low.

Domain (FT)

31..49; EF-hand 1; 51..86; EF-hand 2; 87..122; EF-hand 3; 131..166; EF-hand 4

Clinical Relevance3

Disease Involvement (2)

Cone-rod dystrophyDisease variant

Drugs (2)

AMBROXOL NCGC607

Antibody (2)

HPA005561 HPA075056

Supporting Publications2

PMID	Title	Abstract
31508500	Proteomic profiling of extracellular vesicles allows for human breast cancer subtyping.	No abstract available
38731868	The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.	No abstract available