Protein detail

PI2R

Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)

Protein symbol PI2R	UniProt ID P43119	EVMP score 0.25
Frequency 1	Transmembrane count 7	Protein classification

Basic Information

Protein Names

Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)

Protein Function

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Transmembrane

17..38; Helical; Name=1; 52..76; Helical; Name=2; 95..115; Helical; Name=3; 135..158; Helical; Name=4; 182..208; Helical; Name=5; 236..260; Helical; Name=6; 275..295; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000160013

Entrez Gene Symbol

PTGIR

Frequency

EVMP Score

0.25

Fluorescence & Localization

Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificdeep-layer corticothalamic and 6b

Function & Pathway

Protein Function

FDA approved drug targets:Small molecule drugs
Predicted intracellular proteins
G-protein coupled receptors:GPCRs excl olfactory receptors

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationImmune mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

1 record.

Substrate Gene Symbol	Enzyme Gene Symbol	Enzyme UniProt ID	Residue Type	Residue Offset	Modification	Database	References
PTGIR	PRKCA	P17252	S	328	phosphorylation	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:9722557 phosphoELM:9722557 KEA:9722557 SIGNOR:9722557

Ligand-Receptor Signaling

52 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
transmembrane	transmembrane	GO_Intercell	No	No	No	Yes	No
transmembrane	transmembrane	CellPhoneDB	No	No	No	Yes	No
transmembrane	transmembrane	TopDB	No	No	No	Yes	No
transmembrane	transmembrane	Ramilowski_location	No	No	No	Yes	No
transmembrane	transmembrane	OmniPath	No	No	No	Yes	No
plasma_membrane	plasma_membrane	UniProt_location	No	No	No	Yes	No
plasma_membrane	plasma_membrane	Cellinker	No	No	No	Yes	No
plasma_membrane	plasma_membrane	OmniPath	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	CSPA	No	No	No	Yes	No
plasma_membrane_transmembrane	plasma_membrane_transmembrane	HPMR	No	No	No	Yes	No

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Regulatory Interaction Network

7 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
PI2R	P43119	GNAS3	O95467	Yes	Yes	No	SIGNORHPRDHINTBioGRIDLit-BM-17	BioGRID:11895442 HINT:38335293 HPRD:12488443 HINT:16460020 BioGRID:16114876 SIGNOR:31160049 HINT:16114876 Lit-BM-17:16114876 Lit-BM-17:16352729 Lit-BM-17:11895442 Lit-BM-17:16460020 HINT:16352729 BioGRID:16352729 HINT:12488443 BioGRID:16460020
PI2R	P43119	ALEX	P84996	Yes	Yes	No	SIGNORHPRDHINTBioGRIDLit-BM-17	BioGRID:11895442 HINT:38335293 HPRD:12488443 HINT:16460020 BioGRID:16114876 SIGNOR:31160049 HINT:16114876 Lit-BM-17:16114876 Lit-BM-17:16352729 Lit-BM-17:11895442 Lit-BM-17:16460020 HINT:16352729 BioGRID:16352729 HINT:12488443 BioGRID:16460020
PI2R	P43119	GNAS2	P63092	Yes	Yes	No	SIGNORHPRDHINTBioGRIDLit-BM-17	BioGRID:11895442 HINT:38335293 HPRD:12488443 HINT:16460020 BioGRID:16114876 SIGNOR:31160049 HINT:16114876 Lit-BM-17:16114876 Lit-BM-17:16352729 Lit-BM-17:11895442 Lit-BM-17:16460020 HINT:16352729 BioGRID:16352729 HINT:12488443 BioGRID:16460020
PI2R	P43119	GNAS1	Q5JWF2	Yes	Yes	No	SIGNORHPRDHINTBioGRIDLit-BM-17	BioGRID:11895442 HINT:38335293 HPRD:12488443 HINT:16460020 BioGRID:16114876 SIGNOR:31160049 HINT:16114876 Lit-BM-17:16114876 Lit-BM-17:16352729 Lit-BM-17:11895442 Lit-BM-17:16460020 HINT:16352729 BioGRID:16352729 HINT:12488443 BioGRID:16460020
PI2R	P43119	GNAQ	P50148	Yes	Yes	No	HPRDHINTSIGNOR	SIGNOR:31160049 HINT:11443126 HPRD:11443126 HPRD:10446129 HINT:10446129
KPCA	P17252	PI2R	P43119	Yes	No	No	PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAphosphoELM_KEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper	ProtMapper:9722557 phosphoELM:9722557 PhosphoSite:12016224 KEA:9722557 HPRD:9722557 SIGNOR:9722557 PhosphoSite:9722557
PI2R	P43119	GNAL	P38405	Yes	Yes	No	SIGNOR	SIGNOR:31160049

Protein Complex Composition

0 records.

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Size Exclusion Chromatography	Mass spectrometry	1	38938674

Sequence, Structure & Domains

Sequences

Length

386

Mass

40,956

Sequence

MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC

3D Structural Models

Turn

81..87; 293..295

Helix

18..38; 48..77; 90..121; 124..129; 132..152; 154..156; 179..220; 233..264; 275..292; 297..312

Beta Strand

42..44; 161..163; 165..168; 170..172

3D Structure

Electron microscopy (2)

Domain & Motif Annotations

Compositional Bias

363..376; Polar residues

Region

322..376; Disordered

Protein Families

G-protein coupled receptor 1 family

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Clinical Relevance

Related Diseases

Abortion Arterial occlusive disease Asthma Chronic kidney disease Coronary atherosclerosis Gout Hypertension Pulmonary hypertension Solid tumour/cancer

Biomarker

Approved; Discontinued in Phase 3; Discontinued in Preregistration; Phase 4; Phase 3; Discontinued in Phase 2; Terminated

Drugs

DINOPROST TROMETHAMINE ESUBERAPROST RALINEPAG ASPIRIN BERAPROST MISOPROSTOL TREPROSTINIL DIOLAMINE EPOPROSTENOL TREPROSTINIL SELEXIPAG EPOPROSTENOL SODIUM ILOPROST LAROPIPRANT