Protein detail
PI2R
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
Protein symbol PI2R | UniProt ID | EVMP score 0.25 |
Frequency 1 | Transmembrane count 7 | Protein classification |
Basic Information
Protein Names
Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor)
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Transmembrane
17..38; Helical; Name=1; 52..76; Helical; Name=2; 95..115; Helical; Name=3; 135..158; Helical; Name=4; 182..208; Helical; Name=5; 236..260; Helical; Name=6; 275..295; Helical; Name=7
Transmembrane Count
7
Ensembl
Entrez Gene Symbol
Frequency
1
EVMP Score
0.25
Fluorescence & Localization
Tissue Specificheart muscleCell SpecificCardiomyocytesSingle-Nuclei Brain Specificdeep-layer corticothalamic and 6b
Function & Pathway
Protein Function
- FDA approved drug targets:Small molecule drugs
- Predicted intracellular proteins
- G-protein coupled receptors:GPCRs excl olfactory receptors
Cellular Component
Molecular Function
Biological Process
KEGG
Reactome
- R-hsa-373076 class a 1 rhodopsin like receptors
- R-hsa-391903 eicosanoid ligand binding receptors
- R-hsa-500792 gpcr ligand binding
- R-hsa-418555 g alpha s signalling events
- R-hsa-109582 hemostasis
- R-hsa-418346 platelet homeostasis
- R-hsa-392851 prostacyclin signalling through prostacyclin receptor
- R-hsa-391908 prostanoid ligand receptors
- R-hsa-372790 signaling by gpcr
Mediation Categories
Clinical-translation mediationImmune mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
1 record.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| PTGIR | PRKCA | P17252 | S | 328 | phosphorylation | PhosphoNetworksphosphoELM_MIMPPhosphoSite_MIMPMIMPHPRD_MIMPSIGNORProtMapperKEAphosphoELMSIGNOR_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:9722557phosphoELM:9722557KEA:9722557SIGNOR:9722557 |
Ligand-Receptor Signaling
52 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | HGNC | No | Yes | No | Yes | No |
| transmembrane | transmembrane_predicted | Phobius | No | No | No | Yes | No |
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Regulatory Interaction Network
7 records.
Protein Complex Composition
0 records.
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Size Exclusion Chromatography | Mass spectrometry | 1 | 38938674 |
Sequence, Structure & Domains
Sequences
Length
386
Mass
40,956
Sequence
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
3D Structural Models
Turn
81..87; 293..295
Helix
18..38; 48..77; 90..121; 124..129; 132..152; 154..156; 179..220; 233..264; 275..292; 297..312
Beta Strand
42..44; 161..163; 165..168; 170..172
3D Structure
Electron microscopy (2)
Domain & Motif Annotations
Compositional Bias
363..376; Polar residues
Region
322..376; Disordered
Protein Families
G-protein coupled receptor 1 family
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Clinical Relevance
Related Diseases
Biomarker
Approved; Discontinued in Phase 3; Discontinued in Preregistration; Phase 4; Phase 3; Discontinued in Phase 2; Terminated