Protein detail

GLP1R

Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)

Protein symbol GLP1R	UniProt ID P43220	EVMP score 0.50
Frequency 1	Transmembrane count 7	Protein classification

EVMP score: annotation confidence score.

Extremely high >= 0.85High >= 0.70Medium >= 0.55Low >= 0.40

Basic Information

Protein Names

Glucagon-like peptide 1 receptor (GLP-1 receptor) (GLP-1-R) (GLP-1R)

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Transmembrane

140..164; Helical; Name=1; 176..201; Helical; Name=2; 228..251; Helical; Name=3; 266..290; Helical; Name=4; 306..328; Helical; Name=5; 349..370; Helical; Name=6; 384..404; Helical; Name=7

Transmembrane Count

Ensembl

ENSG00000112164

Entrez Gene Symbol

GLP1R

Frequency

EVMP Score

0.50

Fluorescence & Localization

Function & Pathway

Protein Function

G-protein coupled receptors:Family 2 (B) receptors
Transporters
G-protein coupled receptors:GPCRs excl olfactory receptors
FDA approved drug targets:Small molecule drugs
FDA approved drug targets:Biotech drugs

Cellular Component

Molecular Function

Biological Process

KEGG

Reactome

Mediation Categories

Clinical-translation mediationFusion and delivery mediationMetabolism mediationReceptor-signaling mediation

Relations & Evidence

Enzyme-Mediated Modification

0 records.

Ligand-Receptor Signaling

56 records.

Category	Parent	Database	Transmitter	Receiver	Secreted	Plasma Membrane (Transmembrane)	Plasma Membrane (Peripheral)
receptor	receptor	CellPhoneDB	No	Yes	No	Yes	No
receptor	receptor	HPMR	No	Yes	No	Yes	No
receptor	receptor	CellChatDB	No	Yes	No	Yes	No
receptor	receptor	CellTalkDB	No	Yes	No	Yes	No
receptor	receptor	Surfaceome	No	Yes	No	Yes	No
receptor	receptor	Ramilowski2015	No	Yes	No	Yes	No
receptor	receptor	Guide2Pharma	No	Yes	No	Yes	No
gpcr	receptor	DGIdb	No	Yes	No	Yes	No
receptor	receptor	LRdb	No	Yes	No	Yes	No
receptor	receptor	Baccin2019	No	Yes	No	Yes	No

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Regulatory Interaction Network

5 records.

Source Protein Symbol	Source UniProt ID	Target Protein Symbol	Target UniProt ID	Is Directed	Is Stimulation	Is Inhibition	Database	References
GLUC	P01275	GLP1R	P43220	Yes	Yes	No	iTALKGuide2Pharma_LRdbSIGNORHINTHPMR_talklrHPMRCellChatDBHPRD_LRdbtalklrscConnectHPRDRamilowski2015_Baccin2019Guide2Pharma_CellinkerWangRamilowski2015HPMR_LRdbCellPhoneDBGuide2Pharma_talklrHPRD_talklrBioGRIDBaccin2019CellinkerSTRING_talklrCellCallGuide2PharmaCellTalkDBFantom5_LRdbHPMR_CellinkerconnectomeDB2020LRdb	Cellinker:7937318 BioGRID:11116211 CellTalkDB:11116211 LRdb:8404634 Guide2Pharma:8404634 Guide2Pharma:15528268 Baccin2019:15528268 Cellinker:8404634 HINT:26308095 LRdb:11116211 connectomeDB2020:8404634 Baccin2019:7937318 connectomeDB2020:15528268 connectomeDB2020:7937318 scConnect:15528268 HINT:34145245 LRdb:15528268 Cellinker:15528268 SIGNOR:7937318 HINT:19861722 HPRD:11116211 HINT:32690941 LRdb:7937318 scConnect:8404634 BioGRID:18248821 HINT:29877701 HINT:11116211 Cellinker:11116211 Baccin2019:11116211 Baccin2019:8404634 HINT:33027691 connectomeDB2020:11116211 HPMR:8404634
GLP1R	P43220	GNAS3	O95467	Yes	Yes	No	HINTSIGNOR	HINT:33957078 HINT:31915381 HINT:29466332 HINT:33177239 HINT:34145245 HINT:34260945 HINT:26272612 HINT:32690941 HINT:34547628 HINT:35013280 SIGNOR:35065096 HINT:32724086 HINT:35217653 HINT:34937906 HINT:38346960 HINT:33027691
GLP1R	P43220	ALEX	P84996	Yes	Yes	No	HINTSIGNOR	HINT:33957078 HINT:31915381 HINT:29466332 HINT:33177239 HINT:34145245 HINT:34260945 HINT:26272612 HINT:32690941 HINT:34547628 HINT:35013280 SIGNOR:35065096 HINT:32724086 HINT:35217653 HINT:34937906 HINT:38346960 HINT:33027691
GLP1R	P43220	GNAS2	P63092	Yes	Yes	No	HINTSIGNOR	HINT:33957078 HINT:31915381 HINT:29466332 HINT:33177239 HINT:34145245 HINT:34260945 HINT:26272612 HINT:32690941 HINT:34547628 HINT:35013280 SIGNOR:35065096 HINT:32724086 HINT:35217653 HINT:34937906 HINT:38346960 HINT:33027691
GLP1R	P43220	GNAS1	Q5JWF2	Yes	Yes	No	HINTSIGNOR	HINT:33957078 HINT:31915381 HINT:29466332 HINT:33177239 HINT:34145245 HINT:34260945 HINT:26272612 HINT:32690941 HINT:34547628 HINT:35013280 SIGNOR:35065096 HINT:32724086 HINT:35217653 HINT:34937906 HINT:38346960 HINT:33027691

Protein Complex Composition

2 records.

Component Name	Component Gene Symbols	Component UniProt ID	Stoichiometry	Database	Database IDs	References
	GCG GLP1R	P01275 P43220	2:2	PDB	PDB:3iolPDB:4zgmPDB:5otvPDB:5otxPDB:5otuPDB:5otw
	GLP1R	P43220	2	PDB	PDB:6kk1PDB:6kjvPDB:5vewPDB:5e94PDB:6kk7PDB:5vex

Isolation & Detection Technology

1 record.

EV Isolation Method	Detection Method	Number of References	References
Differential UltracentrifugationUltrafiltration / Tangential Flow FiltrationSize Exclusion Chromatography	Mass spectrometryWestern blottingFlow cytometryELISA	14	38938674 26538482 34071777 38225453 32795414 27723984 30071318 36362114 37686366 30760538 37922300 40311616 40091455 30451371

Sequence, Structure & Domains

Sequences

Length

463

Mass

53,026

Sequence

MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS

3D Structural Models

Turn

105..107; 220..222; 294..298; 366..369; 372..374; 403..405; 419..422

Helix

32..52; 92..94; 124..126; 137..142; 145..168; 170..172; 175..204; 207..215; 216..219; 224..255; 264..291; 303..337; 345..360; 362..365; 378..392; 394..402; 407..418

Beta Strand

53..56; 57..59; 68..72; 79..84; 87..89; 95..97; 99..104; 108..110; 112..114; 116..119; 256..258

3D Structure

Electron microscopy (42); X-ray crystallography (14)

Domain & Motif Annotations

Region

352..355; Important for allosteric inhibitor binding

Protein Families

G-protein coupled receptor 2 family

Sequence Similarities

Belongs to the G-protein coupled receptor 2 family.

Clinical Relevance

Related Diseases

Acute diabete complication Alzheimer disease Cardiovascular disease Diabetes mellitus Dyspepsia Hypo-glycaemia Intracranial injury Irritable bowel syndrome Non-alcoholic fatty liver disease Obesity Pancreatic internal secretion disorder Parkinsonism Type 2 diabetes mellitus Type-1/2 diabete

Biomarker

Phase 3; Phase 2; Discontinued in Phase 1/2; Approved

Drugs

CHEMBL:CHEMBL259615 LIRAGLUTIDE CHEMBL:CHEMBL1520282 CHEMBL:CHEMBL86464 CHEMBL:CHEMBL493863 CHEMBL:CHEMBL588683 AMCINAFIDE CHEMBL:CHEMBL581865 NULL CHEMBL:CHEMBL591598 CGP13501 CORONOPILIN ASTERRIC ACID 6-AZAURIDINE CHEMBL:CHEMBL576809 CHEMBL:CHEMBL582286 ETOPOSIDE CLOZAPINE ANGUSTIBALIN EXENATIDE CHEMBL:CHEMBL1422704 CHEMBL:CHEMBL584269 CYCLOHEXIMIDE PYRITHIONE CHEMBL:CHEMBL589245 CHEMBL:CHEMBL261693 VILDAGLIPTIN CHEMBL:CHEMBL1569494 SCOULERINE CHEMBL:CHEMBL585443 LASALOCID A SODIUM CHEMBL:CHEMBL597251 CHEMBL:CHEMBL1327172 CHEMBL:CHEMBL597244 CHEMBL:CHEMBL586163 CLOTRIMAZOLE CHEMBL:CHEMBL1466186 CHEMBL:CHEMBL1509103 FENTICLOR CLANFENUR TASPOGLUTIDE PEGAPAMODUTIDE SEMAGLUTIDE AURIN CHEMBL:CHEMBL605708 CHEMBL:CHEMBL589909 GLP-1 MITONAFIDE CHEMBL:CHEMBL588038 CHEMBL:CHEMBL581152 CHEMBL:CHEMBL530609 ALBIGLUTIDE NORTRIPTYLINE HYDROCHLORIDE CGP7930 CHEMBL:CHEMBL601351 HELENALIN CHEMBL:CHEMBL1437888 CHEMBL:CHEMBL579318 PAROXETINE HYDROCHLORIDE, HEMIHYDRATE CHEMBL:CHEMBL584458 CHEMBL:CHEMBL532412 CHEMBL:CHEMBL1224483 CHEMBL:CHEMBL591126 DULAGLUTIDE CHEMBL:CHEMBL603130 DIHYDROXANTHOHUMOL EFPEGLENATIDE CHEMBL:CHEMBL127579 PYRONIN Y CHEMBL:CHEMBL1337519 CHEMBL:CHEMBL1549738 CHEMBL:CHEMBL533602 CHEMBL:CHEMBL405914 CHEMBL:CHEMBL1170485 CHEMBL:CHEMBL1390716 TRICLABENDAZOLE DIGITOXIGENIN CHEMBL:CHEMBL603154 CYCLOASPEPTIDE A MOFEBUTAZONE DANUGLIPRON CHEMBL:CHEMBL607309 CHEMBL:CHEMBL599100 HOMIDIUM BROMIDE PROPIONYLPROMAZINE HYDROCHLORIDE CHEMBL:CHEMBL533082 FIDUXOSIN HYDROCHLORIDE METAPHIT METHANESULFONATE CHEMBL:CHEMBL604664 CHEMBL:CHEMBL532452 CHEMBL:CHEMBL579956 NLY-01 CHEMBL:CHEMBL1439833 CHEMBL:CHEMBL590919 CHEMBL:CHEMBL260451 SAR 425899.00 AVEXITIDE EFINOPEGDUTIDE SMD-3040 CHEMBL:CHEMBL600734 CHEMBL:CHEMBL590427 KEPONE OXYCARBOXIN CHEMBL:CHEMBL1543865 A947 GERONTOXANTHONE H CHEMBL:CHEMBL317115 CHEMBL:CHEMBL602012 CHEMBL:CHEMBL578928 LIXISENATIDE GNE-064 PRAMLINTIDE CLOXYQUIN CHEMBL:CHEMBL586078 CHEMBL:CHEMBL588028 INDOPROFEN CHEMBL:CHEMBL585444 CHEMBL:CHEMBL602923 CHEMBL:CHEMBL1308346 CHEMBL:CHEMBL259805 CHEMBL:CHEMBL524376 FENBENDAZOLE CHEMBL:CHEMBL1472891 CHEMBL:CHEMBL604321 TRIFLUOPERAZINE CHEMBL:CHEMBL1270168 CHEMBL:CHEMBL578515 TH0318 CHEMBL:CHEMBL592118 BENZPIPERYLON CHEMBL:CHEMBL580727 CHEMBL:CHEMBL591834 MAGNOLOL CHEMBL:CHEMBL1420370 COLFORSIN ENCLOMIPHENE CHEMBL:CHEMBL528181 CHEMBL:CHEMBL482050 STROPHANTHIDIN CHEMBL:CHEMBL580340 CHEMBL:CHEMBL581872 OLANZAPINE PYROXAMINE MALEATE PFI-3 TIRZEPATIDE CHEMBL:CHEMBL580076 CHEMBL:CHEMBL589670 MEPAZINE ACETATE DESIPRAMINE HYDROCHLORIDE 2-METHOXYESTRADIOL CHEMBL:CHEMBL606460 DULOXETINE HYDROCHLORIDE ALBUTEROL SULFATE CHEMBL:CHEMBL580207 CHEMBL:CHEMBL528791 AMORFRUTIN A CETYLPYRIDINIUM BROMIDE COTADUTIDE CHEMBL:CHEMBL587564 CHEMBL:CHEMBL590686 CHEMBL:CHEMBL601400 SITAGLIPTIN CHEMBL:CHEMBL548286 PINAFIDE