Protein detail
KSYK
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Protein symbol KSYK | UniProt ID | EVMP score 0.50 |
Frequency 4 | Transmembrane count | Protein classification Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteins |
Basic Information
Protein Names
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Protein Class
Cancer-related genesDisease related genesEnzymesFDA approved drug targetsHuman disease related genesPredicted intracellular proteins
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Cancer-related genes
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Ensembl
Entrez Gene Symbol
Gene Description
Spleen associated tyrosine kinase
Chromosome
9
Position
90801787-90898549
Frequency
4
EVMP Score
0.50
Fluorescence & Localization
Cell SpecificPlateletsSingle-Nuclei Brain Specificendothelial cell
Function & Pathway
Protein Function
- Predicted intracellular proteins
- ENZYME proteins:Transferases
- Human disease related genes:Immune system diseases:Primary immunodeficiency
- Enzymes
- Cancer-related genes
- Kinases:Tyr protein kinases
- Disease related genes
- FDA approved drug targets:Small molecule drugs
Cellular Component
Molecular Function
- GO:0001784 phosphotyrosine residue binding
- GO:0004672 protein kinase activity
- GO:0004674 protein serine/threonine kinase activity
- GO:0004713 protein tyrosine kinase activity
- GO:0004715 non-membrane spanning protein tyrosine kinase activity
- GO:0005102 signaling receptor binding
- GO:0005178 integrin binding
- GO:0005515 protein binding
- GO:0005524 ATP binding
- GO:0016170 interleukin-15 receptor binding
- GO:0016301 kinase activity
- GO:0019901 protein kinase binding
- GO:0019902 phosphatase binding
- GO:0035325 Toll-like receptor binding
- GO:0042169 SH2 domain binding
- GO:0043274 phospholipase binding
- GO:0097110 scaffold protein binding
Biological Process
KEGG
- hsa04064 NF-kappa B signaling pathway
- KEGG:hsa04072 Phospholipase D signaling pathway
- KEGG:hsa04151 PI3K-Akt signaling pathway
- KEGG:hsa04380 Osteoclast differentiation
- KEGG:hsa04611 Platelet activation
- KEGG:hsa04613 Neutrophil extracellular trap formation
- KEGG:hsa04625 C-type lectin receptor signaling pathway
- KEGG:hsa04650 Natural killer cell mediated cytotoxicity
- KEGG:hsa04662 B cell receptor signaling pathway
- KEGG:hsa04664 Fc epsilon RI signaling pathway
- KEGG:hsa04666 Fc gamma R-mediated phagosome formation
- KEGG:hsa05152 Tuberculosis
- KEGG:hsa05167 Kaposi sarcoma-associated herpesvirus infection
- KEGG:hsa05168 Herpes simplex virus 1 infection
- KEGG:hsa05169 Epstein-Barr virus infection
- KEGG:hsa05171 Coronavirus disease
- KEGG:hsa05203 Viral carcinogenesis
Reactome
- R-hsa-1280218 adaptive immune system
- R-hsa-983695 antigen activates b cell receptor bcr leading to generation of second messengers
- R-hsa-9662851 anti inflammatory response favouring leishmania parasite infection
- R-hsa-5607764 clec7a dectin 1 signaling
- R-hsa-1280215 cytokine signaling in immune system
- R-hsa-5621481 c type lectin receptors clrs
- R-hsa-2172127 dap12 interactions
- R-hsa-2424491 dap12 signaling
- R-hsa-5621480 dectin 2 family
- R-hsa-2871809 fceri mediated ca 2 mobilization
- R-hsa-2871796 fceri mediated mapk activation
- R-hsa-2029480 fcgamma receptor fcgr dependent phagocytosis
- R-hsa-9664323 fcgr3a mediated il10 synthesis
- R-hsa-2029481 fcgr activation
- R-hsa-2454202 fc epsilon receptor fceri signaling
- R-hsa-9607240 flt3 signaling
- R-hsa-9706374 flt3 signaling through src family kinases
- R-hsa-114604 gpvi mediated activation cascade
- R-hsa-109582 hemostasis
- R-hsa-9705462 inactivation of csf3 g csf signaling
- R-hsa-5663205 infectious disease
- R-hsa-168249 innate immune system
- R-hsa-354192 integrin signaling
- R-hsa-451927 interleukin 2 family signaling
- R-hsa-9020558 interleukin 2 signaling
- R-hsa-512988 interleukin 3 interleukin 5 and gm csf signaling
- R-hsa-9658195 leishmania infection
- R-hsa-9664407 parasite infection
- R-hsa-76002 platelet activation signaling and aggregation
- R-hsa-76009 platelet aggregation plug formation
- R-hsa-9679191 potential therapeutics for sars
- R-hsa-912631 regulation of signaling by cbl
- R-hsa-2730905 role of lat2 ntal lab on calcium mobilization
- R-hsa-2029485 role of phospholipids in phagocytosis
- R-hsa-9679506 sars cov infections
- R-hsa-9674555 signaling by csf3 g csf
- R-hsa-449147 signaling by interleukins
- R-hsa-983705 signaling by the b cell receptor bcr
- R-hsa-9824446 viral infection pathways
Mediation Categories
Adhesion and uptake mediationClinical-translation mediationFusion and delivery mediationImmune mediationMetabolism mediationReceptor-signaling mediation
Relations & Evidence
Enzyme-Mediated Modification
29 records.
| Substrate Gene Symbol | Enzyme Gene Symbol | Enzyme UniProt ID | Residue Type | Residue Offset | Modification | Database | References |
|---|---|---|---|---|---|---|---|
| SYK | LYN | P07948 | Y | 323 | phosphorylation | Sparser_ProtMapperProtMapperdbPTMKEAPhosphoSite | dbPTM:17389395ProtMapper:25045209dbPTM:19369195KEA:9820500dbPTM:18083107dbPTM:21469132 |
| SYK | LYN | P07948 | Y | 131 | phosphorylation | MIMPHPRDHPRD_MIMPKEA | HPRD:9820500KEA:9820500 |
| SYK | LYN | P07948 | Y | 348 | phosphorylation | PhosphoSiteKEA | KEA:8657103 |
| SYK | LYN | P07948 | Y | 526 | phosphorylation | PhosphoSite | |
| SYK | LYN | P07948 | Y | 352 | phosphorylation | PhosphoSiteKEA | KEA:8657103 |
| SYK | LYN | P07948 | Y | 525 | phosphorylation | PhosphoSite | |
| SYK | SRC | P12931 | Y | 296 | phosphorylation | Li2012 | |
| SYK | SRC | P12931 | Y | 323 | phosphorylation | Li2012 | |
| SYK | CHEK1 | O14757 | S | 295 | phosphorylation | Sparser_ProtMapperPhosphoSite_MIMPMIMPSIGNORProtMapperSIGNOR_ProtMapperREACH_ProtMapperPhosphoSitePhosphoSite_ProtMapper | ProtMapper:27381982ProtMapper:25447675ProtMapper:22585575SIGNOR:22585575 |
| SYK | SRC | P12931 | Y | 525 | phosphorylation | REACH_ProtMapperProtMapper | ProtMapper:23100514 |
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Ligand-Receptor Signaling
13 records.
| Category | Parent | Database | Transmitter | Receiver | Secreted | Plasma Membrane (Transmembrane) | Plasma Membrane (Peripheral) |
|---|---|---|---|---|---|---|---|
| receptor | receptor | OmniPath | No | Yes | No | No | No |
| intracellular | intracellular | LOCATE | No | No | No | No | No |
| intracellular | intracellular | ComPPI | No | No | No | No | No |
| intracellular | intracellular | GO_Intercell | No | No | No | No | No |
| intracellular | intracellular | UniProt_location | No | No | No | No | No |
| intracellular | intracellular | OmniPath | No | No | No | No | No |
| cell_adhesion | cell_adhesion | Cellinker | Yes | Yes | No | No | No |
| adhesion | adhesion | OmniPath | Yes | Yes | No | No | No |
| cell_adhesion | cell_adhesion | OmniPath | Yes | Yes | No | No | No |
| plasma_membrane | plasma_membrane | UniProt_location | No | No | No | No | No |
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Regulatory Interaction Network
56 records.
| Source Protein Symbol | Source UniProt ID | Target Protein Symbol | Target UniProt ID | Is Directed | Is Stimulation | Is Inhibition | Database | References |
|---|---|---|---|---|---|---|---|---|
| COMPLEX:P0DOX6_P0DOX8_P11912_P40259 | KSYK | P43405 | Yes | Yes | No | SIGNOR | SIGNOR:32323266 | |
| KSYK | P43405 | KPCA | P17252 | Yes | Yes | No | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEAHPRDWangphosphoELM_MIMPPhosphoSite_MIMPMIMPiPTMnetPhosphoPointKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperSparser_ProtMapperAdhesomeHPRD-phos | Adhesome:12881490ProtMapper:12881490Adhesome:15583006HPRD:12881490HPRD-phos:12881490KEA:12881490ProtMapper:20068231HPRD-phos:20068231Adhesome:9531509SIGNOR:12881490KEA:17192257phosphoELM:12881490 |
| KSYK | P43405 | SYUA | P37840 | Yes | Yes | Yes | HPRD_MIMPSIGNORProtMapperPhosphoSite_KEAphosphoELM_KEALi2012PhosphoNetworksNCI-PID_ProtMapperHPRDWangPhosphoSite_ProtMapperphosphoELM_MIMPPhosphoSite_MIMPMIMPPhosphoSite_norefPhosphoPointiPTMnetKEAHPRD_KEAphosphoELMSIGNOR_ProtMapperPhosphoSiteHPRD-phos | HPRD-phos:11744621HPRD-phos:12096713PhosphoSite:11744621ProtMapper:12096713KEA:12096713PhosphoSite:11078745phosphoELM:11744621ProtMapper:11744621KEA:11744621KEA:11162638HPRD:12096713HPRD-phos:11162638ProtMapper:11162638SIGNOR:11744621HPRD:11162638HPRD:11744621KEA:12893833 |
| SH2B1 | Q9NRF2 | KSYK | P43405 | Yes | No | Yes | SIGNOR | SIGNOR:32323266 |
| COMPLEX:P0DOX3_P0DOX8_P11912_P40259 | KSYK | P43405 | Yes | Yes | No | SIGNOR | SIGNOR:32323266 | |
| KSYK | P43405 | I15RA | Q13261 | Yes | Yes | No | MIMPHPRD_MIMPiPTMnetPhosphoPointSIGNORProtMapperHPRDPhosphoSite_KEAKEAHPRD_KEASIGNOR_ProtMapper | HPRD:11714793SIGNOR:11714793ProtMapper:11714793KEA:11714793 |
| FCRL3 | Q96P31 | KSYK | P43405 | Yes | Yes | No | SIGNOR | SIGNOR:12051764 |
| COMPLEX:P0DOX6_P0DOX7_P11912_P40259 | KSYK | P43405 | Yes | Yes | No | SIGNOR | SIGNOR:32323266 | |
| KSYK | P43405 | DPTOR | Q8TB45 | Yes | No | Yes | SIGNOR | SIGNOR:34634301 |
| PTN11 | Q06124 | KSYK | P43405 | Yes | No | Yes | SIGNORAdhesome | Adhesome:10942405SIGNOR:23182168 |
Protein Complex Composition
Isolation & Detection Technology
1 record.
| EV Isolation Method | Detection Method | Number of References | References |
|---|---|---|---|
| Differential UltracentrifugationSize Exclusion ChromatographyImmunoaffinity Capture | Mass Spectrometry | 1 | 38113368 |
Sequence, Structure & Domains
Sequences
Length
635
Mass
72,066
Sequence
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=P43405-1; Sequence=Displayed; Name=Short; IsoId=P43405-2; Sequence=VSP_005010
Alternative Sequence
283..305; Missing (in isoform Short)
3D Structural Models
Turn
567..569; 572..575
Helix
10..12; 22..31; 85..92; 119..136; 140..158; 163..165; 175..183; 237..244; 342..344; 346..348; 351..353; 360..363; 367..369; 411..424; 456..462; 468..487; 497..499; 513..515; 536..538; 541..546; 551..566; 578..586; 599..608; 613..615; 619..624
Beta Strand
38..43; 47..49; 51..57; 60..68; 74..76; 82..84; 99..101; 169..172; 184..186; 187..189; 192..201; 203..209; 212..220; 221..224; 226..228; 229..231; 234..236; 251..253; 370..372; 377..380; 384..391; 393..409; 435..449; 500..504; 507..510; 524..527; 548..550; 589..591
3D Structure
NMR spectroscopy (2); X-ray crystallography (91)
Domain & Motif Annotations
Domain (CC)
The SH2 domains mediate the interaction of SYK with the phosphorylated ITAM domains of transmembrane proteins. Some proteins like CLEC1B have a partial ITAM domain (also called hemITAM) containing a single YxxL motif. The interaction with SYK requires CLEC1B homodimerization.
Domain (FT)
15..107; SH2 1; 168..259; SH2 2; 371..631; Protein kinase
Region
108..167; Interdomain A; 260..370; Interdomain B
Protein Families
- Protein kinase superfamily
- Tyr protein kinase family
- SYK/ZAP-70 subfamily
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
Clinical Relevance
Disease Involvement
Cancer-related genesDisease variantFDA approved drug targets
Related Diseases
Acquired hypomelanotic disorderAcute myeloid leukaemiaAllergic/hypersensitivity disorderAsthmaAtopic eczemaB-cell lymphomaChronic obstructive pulmonary diseaseCutaneous lupus erythematosusDiabetes mellitusDiffuse large B-cell lymphomaMalignant haematopoietic neoplasmMature B-cell leukaemiaRheumatoid arthritisSolid tumour/cancerThrombocytopeniaThrombosisUrticaria
Biomarker
Phase 1; Phase 2; Investigative; Phase 3; Approved
Drug Targets
FDA approved drug targets
Drugs
CYC-116FOSTAMATINIBNULLCEDIRANIBPRT-2607P505-15PACLITAXELR-343GW441756XCHEMBL:CHEMBL379975R-348NVP-TAE684GUSACITINIBR-112LANRAPLENIBMIVAVOTINIB CITRATER-333FOSTAMATINIB DISODIUMSP-600125ENTOSPLETINIBCERDULATINIBTAMATINIBPD-0166285CHEMBL:CHEMBL535331CEVIDOPLENIB DIMESYLATEILORASERTIBADAVOSERTIBRG-1530DASATINIB ANHYDROUSIMATINIBERLOTINIBENTRECTINIBSOVLEPLENIBCENISERTIBGSK2646264
Interaction Protein
ENSG00000110395ENSG00000112773ENSG00000145675ENSG00000146648ENSG00000154127ENSG00000155313ENSG00000158869ENSG00000182866
Interaction Count
8
Interaction Dataset
intact_biogrid