Protein detail

KI2L3

Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)

Entry name
KI2L3
UniProt ID
P43628
EVMP confidence score
0.53
Supporting publications (n)
3
Transmembrane count
1
Protein classification
Basic Information
Protein Names
Killer cell immunoglobulin-like receptor 2DL3 (CD158 antigen-like family member B2) (KIR-023GB) (Killer inhibitory receptor cl 2-3) (NKAT2a) (NKAT2b) (Natural killer-associated transcript 2) (NKAT-2) (p58 natural killer cell receptor clone CL-6) (p58 NK receptor CL-6) (p58.2 MHC class-I-specific NK receptor) (CD antigen CD158b2)
Protein Function
CD markers
Transmembrane
246..265; Helical
Transmembrane Count
1
Ensembl
ENSG00000243772
Entrez Gene Symbol
KIR2DL3
Supporting publications (n)
3
EVMP confidence score
0.53
Function & Pathway
Protein Function
CD markers
Cellular Component (2)
Molecular Function (4)
Biological Process (3)
KEGG (3)
Reactome (2)
Mediation Categories
Immune mediation
Relations & Evidence50

Ligand-Receptor Signaling (49)

49 records.

CategoryParentDatabaseTransmitterReceiverSecretedPlasma Membrane (Transmembrane)Plasma Membrane (Peripheral)
cell_adhesioncell_adhesionZhong2015YesYesYes
icamcell_adhesionZhong2015YesYesYes
adhesionadhesionOmniPathYesYesYes
cell_adhesioncell_adhesionOmniPathYesYesYes
transmembranetransmembraneUniProt_locationYes
transmembranetransmembraneUniProt_topologyYes
transmembranetransmembraneUniProt_keywordYes
transmembranetransmembraneCellPhoneDBYes
transmembranetransmembraneTopDBYes
transmembranetransmembraneLOCATEYes
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Isolation & Detection Technology (1)

1 record.

EV Isolation MethodDetection MethodNumber of ReferencesReferences
Differential UltracentrifugationMass spectrometry138321535
Sequence, Structure & Domains

Sequences

Length
341
Mass
37,886
Sequence
MSLMVVSMVCVGFFLLQGAWPHEGVHRKPSLLAHPGPLVKSEETVILQCWSDVRFQHFLLHREGKFKDTLHLIGEHHDGVSKANFSIGPMMQDLAGTYRCYGSVTHSPYQLSAPSDPLDIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSRSSYDMYHLSREGEAHERRFSAGPKVNGTFQADFPLGPATHGGTYRCFGSFRDSPYEWSNSSDPLLVSVTGNPSNSWPSPTEPSSETGNPRHLHVLIGTSVVIILFILLLFFLLHRWCCNKKNAVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQRKITRPSQRPKTPPTDIIVYTELPNAEP
Alternative Products
Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P43628-1; Sequence=Displayed; Name=2; Synonyms=NKAT2a-delta-Ig2; IsoId=P43628-2; Sequence=VSP_007814
Alternative Sequence
117..214; Missing (in isoform 2)

3D Structural Models

Helix
92..94
Beta Strand
30..35; 37..40; 45..53; 56..66; 68..73; 75..77; 80..87; 96..101; 118..123; 130..135; 147..153; 156..160; 177..179; 181..183; 198..202; 205..209; 216..218
3D Structure
X-ray crystallography (3)

Domain & Motif Annotations

Compositional Bias
223..239; Low complexity
Domain (FT)
42..107; Ig-like C2-type 1; 142..205; Ig-like C2-type 2
Region
220..239; Disordered
Protein Families
Immunoglobulin superfamily
Sequence Similarities
Belongs to the immunoglobulin superfamily.
Clinical Relevance
Drugs (4)
LIRILUMABIPH-2101NULLRECOMBINANT INTERFERON
Interaction Protein
ENSG00000204525
Interaction Count
1
Interaction Dataset
intact_biogrid
Supporting Publications3
PMIDTitleRelated sentences
26775013Proteomic characterization of circulating extracellular vesicles identifies novel serum myeloma associated markers.No related sentences available
30382917Discovery of a diagnostic biomarker for colon cancer through proteomic profiling of small extracellular vesicles.No related sentences available
38731868The Deep Proteomics Approach Identified Extracellular Vesicular Proteins Correlated to Extracellular Matrix in Type One and Two Endometrial Cancer.No related sentences available